Idiopathic central diabetes insipidus

Chun Chi Chen, Tsung Yun Hou, Chih Jen Cheng, Shih Hua Lin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Idiopathic central diabetes insipidus (CDI) is a rare disorder characterized clinically by polyuria and polydipsia, and an abnormal urinary concentration without any identified etiology. Two young adults with abrupt onset of polydipsia, polyuria, and excessive thirst sought our attention. None had neurological deficits or a family history of diabetes insipidus. Low urine osmolality persisted despite water deprivation and urine osmolality increased dramatically after the deamino-D-arginine-8-vasopressin (dDAVP) test, observations consistent with the diagnosis of CDI. Anterior pituitary dysfunction was absent. Magnetic resonance imaging (MRI) of the brains of both cases showed normal anatomical structures, except for the absence of a normal hyperintense signal in the posterior pituitary. Secondary causes of CDI including trauma, infection, autoimmunity, and infiltrative disorders were excluded. Genetic analysis also revealed no mutations in the arginine vasopressin-neurophysin II gene. After dDAVP administration via nasal spray, their symptoms related to CDI were completely resolved. The brain MRI at regular follow-up remained unchanged for 3 years. Exclusion of organic brain disease and the absence of mutations in the gene encoding arginine vasopressin are essential for the diagnosis of idiopathic CDI.

Original languageEnglish
Pages (from-to)259-263
Number of pages5
JournalJournal of Medical Sciences
Volume25
Issue number5
Publication statusPublished - Oct 1 2005
Externally publishedYes

Fingerprint

Neurogenic Diabetes Insipidus
Arginine Vasopressin
Polydipsia
Polyuria
Osmolar Concentration
Magnetic Resonance Imaging
Urine
Neurophysins
Water Deprivation
Nasal Sprays
Thirst
Diabetes Insipidus
Mutation
Brain
Brain Diseases
Autoimmunity
Genes
Young Adult
Wounds and Injuries
Infection

Keywords

  • Antidiuretic hormone
  • Idiopathic central diabetes insipidus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Chen, C. C., Hou, T. Y., Cheng, C. J., & Lin, S. H. (2005). Idiopathic central diabetes insipidus. Journal of Medical Sciences, 25(5), 259-263.

Idiopathic central diabetes insipidus. / Chen, Chun Chi; Hou, Tsung Yun; Cheng, Chih Jen; Lin, Shih Hua.

In: Journal of Medical Sciences, Vol. 25, No. 5, 01.10.2005, p. 259-263.

Research output: Contribution to journalArticle

Chen, CC, Hou, TY, Cheng, CJ & Lin, SH 2005, 'Idiopathic central diabetes insipidus', Journal of Medical Sciences, vol. 25, no. 5, pp. 259-263.
Chen CC, Hou TY, Cheng CJ, Lin SH. Idiopathic central diabetes insipidus. Journal of Medical Sciences. 2005 Oct 1;25(5):259-263.
Chen, Chun Chi ; Hou, Tsung Yun ; Cheng, Chih Jen ; Lin, Shih Hua. / Idiopathic central diabetes insipidus. In: Journal of Medical Sciences. 2005 ; Vol. 25, No. 5. pp. 259-263.
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