Identifying cancer highly-expressed membrane receptors for targeted drug delivery

Wei Chih Huang, Feng Mao Lin, Tzu Hao Chang, Kuang Wen Liao, Hsien Da Huang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Currently, the accompanying side effects of anti-cancer drugs owing to incorrect delivery to normal tissues should be reduced. We present a database (MRTDD) with identified cancer highly-expressed membrane receptors (CHMRs) which can be used in targeted drug delivery. To evaluate the probability of occurrence of incorrect delivery, we calculate tissue index for each CHMR and expect to identify good candidates. The information provided includes: (1) genomic annotations; (2) gene expression profiles of membrane receptors in cancer tissue vs. corresponding normal tissue, normal tissues of body and cancer cell-lines; (3) available antibody services of manufacturers. MRTDD is available at http://mrtdd.mbc.nctu.edu.tw/.

Original languageEnglish
Pages (from-to)192-209
Number of pages18
JournalInternational Journal of Bioinformatics Research and Applications
Volume8
Issue number3-4
DOIs
Publication statusPublished - Sep 2012
Externally publishedYes

Fingerprint

Drug Receptors
Tissue
Membranes
Neoplasms
Transcriptome
Gene expression
Antibodies
Pharmaceutical Preparations
Cells
Targeted drug delivery
Databases
Cell Line

Keywords

  • Bioinformatics
  • Membrane receptor
  • Microarray analysis
  • Targeted drug delivery

ASJC Scopus subject areas

  • Health Informatics
  • Health Information Management
  • Biomedical Engineering
  • Clinical Biochemistry

Cite this

Identifying cancer highly-expressed membrane receptors for targeted drug delivery. / Huang, Wei Chih; Lin, Feng Mao; Chang, Tzu Hao; Liao, Kuang Wen; Huang, Hsien Da.

In: International Journal of Bioinformatics Research and Applications, Vol. 8, No. 3-4, 09.2012, p. 192-209.

Research output: Contribution to journalArticle

Huang, Wei Chih ; Lin, Feng Mao ; Chang, Tzu Hao ; Liao, Kuang Wen ; Huang, Hsien Da. / Identifying cancer highly-expressed membrane receptors for targeted drug delivery. In: International Journal of Bioinformatics Research and Applications. 2012 ; Vol. 8, No. 3-4. pp. 192-209.
@article{9428fb6b6361409cabb1330ce7b9aef7,
title = "Identifying cancer highly-expressed membrane receptors for targeted drug delivery",
abstract = "Currently, the accompanying side effects of anti-cancer drugs owing to incorrect delivery to normal tissues should be reduced. We present a database (MRTDD) with identified cancer highly-expressed membrane receptors (CHMRs) which can be used in targeted drug delivery. To evaluate the probability of occurrence of incorrect delivery, we calculate tissue index for each CHMR and expect to identify good candidates. The information provided includes: (1) genomic annotations; (2) gene expression profiles of membrane receptors in cancer tissue vs. corresponding normal tissue, normal tissues of body and cancer cell-lines; (3) available antibody services of manufacturers. MRTDD is available at http://mrtdd.mbc.nctu.edu.tw/.",
keywords = "Bioinformatics, Membrane receptor, Microarray analysis, Targeted drug delivery",
author = "Huang, {Wei Chih} and Lin, {Feng Mao} and Chang, {Tzu Hao} and Liao, {Kuang Wen} and Huang, {Hsien Da}",
year = "2012",
month = "9",
doi = "10.1504/IJBRA.2012.048965",
language = "English",
volume = "8",
pages = "192--209",
journal = "International Journal of Bioinformatics Research and Applications",
issn = "1744-5485",
publisher = "Inderscience Enterprises Ltd",
number = "3-4",

}

TY - JOUR

T1 - Identifying cancer highly-expressed membrane receptors for targeted drug delivery

AU - Huang, Wei Chih

AU - Lin, Feng Mao

AU - Chang, Tzu Hao

AU - Liao, Kuang Wen

AU - Huang, Hsien Da

PY - 2012/9

Y1 - 2012/9

N2 - Currently, the accompanying side effects of anti-cancer drugs owing to incorrect delivery to normal tissues should be reduced. We present a database (MRTDD) with identified cancer highly-expressed membrane receptors (CHMRs) which can be used in targeted drug delivery. To evaluate the probability of occurrence of incorrect delivery, we calculate tissue index for each CHMR and expect to identify good candidates. The information provided includes: (1) genomic annotations; (2) gene expression profiles of membrane receptors in cancer tissue vs. corresponding normal tissue, normal tissues of body and cancer cell-lines; (3) available antibody services of manufacturers. MRTDD is available at http://mrtdd.mbc.nctu.edu.tw/.

AB - Currently, the accompanying side effects of anti-cancer drugs owing to incorrect delivery to normal tissues should be reduced. We present a database (MRTDD) with identified cancer highly-expressed membrane receptors (CHMRs) which can be used in targeted drug delivery. To evaluate the probability of occurrence of incorrect delivery, we calculate tissue index for each CHMR and expect to identify good candidates. The information provided includes: (1) genomic annotations; (2) gene expression profiles of membrane receptors in cancer tissue vs. corresponding normal tissue, normal tissues of body and cancer cell-lines; (3) available antibody services of manufacturers. MRTDD is available at http://mrtdd.mbc.nctu.edu.tw/.

KW - Bioinformatics

KW - Membrane receptor

KW - Microarray analysis

KW - Targeted drug delivery

UR - http://www.scopus.com/inward/record.url?scp=84866245311&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866245311&partnerID=8YFLogxK

U2 - 10.1504/IJBRA.2012.048965

DO - 10.1504/IJBRA.2012.048965

M3 - Article

C2 - 22961451

AN - SCOPUS:84866245311

VL - 8

SP - 192

EP - 209

JO - International Journal of Bioinformatics Research and Applications

JF - International Journal of Bioinformatics Research and Applications

SN - 1744-5485

IS - 3-4

ER -