Identifying a network of brain regions involved in aversion-related processing: A cross-species translational investigation

Dave J. Hayes, Georg Northoff

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The ability to detect and respond appropriately to aversive stimuli is essential for all organisms, from fruit flies to humans. This suggests the existence of a core neural network which mediates aversion-related processing. Human imaging studies on aversion have highlighted the involvement of various cortical regions, such as the prefrontal cortex, while animal studies have focused largely on subcortical regions like the periaqueductal gray and hypothalamus. However, whether and how these regions form a core neural network of aversion remains unclear. To help determine this, a translational cross-species investigation in humans (i.e., meta-analysis) and other animals (i.e., systematic review of functional neuroanatomy) was performed. Our results highlighted the recruitment of the anterior cingulate cortex, the anterior insula, and the amygdala as well as other subcortical (e.g., thalamus, midbrain) and cortical (e.g., orbitofrontal) regions in both animals and humans. Importantly, involvement of these regions remained independent of sensory modality.This study provides evidence for a core neural network mediating aversion in both animals and humans. This not only contributes to our understanding of the trans-species neural correlates of aversion but may also carry important implications for psychiatric disorders where abnormal aversive behavior can often be observed.

Original languageEnglish
Article number49
JournalFrontiers in Integrative Neuroscience
Volume5
DOIs
Publication statusPublished - 2011
Externally publishedYes

Fingerprint

Brain
Prefrontal Cortex
Neuroanatomy
Periaqueductal Gray
Aptitude
Gyrus Cinguli
Mesencephalon
Amygdala
Thalamus
Diptera
Hypothalamus
Psychiatry
Meta-Analysis
Fruit

Keywords

  • Animal models
  • Aversion
  • Imaging
  • Meta-analysis
  • Translational

ASJC Scopus subject areas

  • Sensory Systems
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

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