Identification of two novel HLA-A*02 variants, A*02: 319 and A*02:01:64, in two Taiwanese marrow stem cell donors by sequence-based typing

K. L. Yang, S. K. Lee, S. Y. Yang, R. H. Kao, C. L. Lin, P. Y. Lin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We report here two novel variants of HLA-A*02 allele, A*02:319 and A*02:01:64, discovered in two Taiwanese unrelated volunteer bone marrow donors by sequence-based typing (SBT) method. The DNA sequence of A*02:319 is identical to A*02:07 in exons 2 and 3 but varies with one nucleotide at codon 9 (TTC->TCC). The variation caused one amino acid substitution at residue 9 (F->S). On the other hand, the DNA sequence of A*02:01:64 is identical to the sequence of A*02:01:01:01 in exons 2 and 3 except a silent mutation at codon 114 (CAC->CAT). The probable HLA-A, HLA-B and HLA-DRB1 haplotypes in association with A*02:319 and A*02:01:64 were deduced as A*02:319-B*46:01-DRB1*04 and A*02:01:64-B*38:02-DRB1*16:02, respectively.

Original languageEnglish
Pages (from-to)261-263
Number of pages3
JournalInternational Journal of Immunogenetics
Volume39
Issue number3
DOIs
Publication statusPublished - Jun 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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