Abstract
Rhesus monkey rhadinovirus (RRV) is a γ2-herpesvirus identified from the peripheral blood mononuclear cells of rhesus macaques (Macaca mulatta). Serologic studies suggested that the infections of RRV are prevalent among rhesus monkeys. RRV can be efficiently propagated and grows to a high titer in cultured rhesus monkey fibroblasts, thus providing a valuable model to study the rhadinovirus replication. By comparative genomic studies, here we describe the identification of two potential transcriptional factors encoded by RRV, designated as R-Rta and R-bZIP. Initial functional characterization of these products suggested that R-Rta is a potent transcriptional activator and R-bZIP forms homodimers in vivo. Viral homologues of R-Rta and R-bZIP, previously identified from other rhadinoviruses, have been implicated in serving as molecular switches in lytic replication.
| Original language | English |
|---|---|
| Pages (from-to) | 181-188 |
| Number of pages | 8 |
| Journal | Virology |
| Volume | 298 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 1 2002 |
| Externally published | Yes |
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Keywords
- bZIP
- KSHV
- Rhesus monkey rhadinovirus
- RNA splicing
- RRV
- Rta
ASJC Scopus subject areas
- Virology
Cite this
Identification of the bZIP and Rta homologues in the genome of rhesus monkey rhadinovirus. / Lin, Su Fang; Robinson, Dan R.; Oh, Joe; Jung, Jae U.; Luciw, Paul A.; Kung, Hsing Jien.
In: Virology, Vol. 298, No. 2, 01.01.2002, p. 181-188.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Identification of the bZIP and Rta homologues in the genome of rhesus monkey rhadinovirus
AU - Lin, Su Fang
AU - Robinson, Dan R.
AU - Oh, Joe
AU - Jung, Jae U.
AU - Luciw, Paul A.
AU - Kung, Hsing Jien
PY - 2002/1/1
Y1 - 2002/1/1
N2 - Rhesus monkey rhadinovirus (RRV) is a γ2-herpesvirus identified from the peripheral blood mononuclear cells of rhesus macaques (Macaca mulatta). Serologic studies suggested that the infections of RRV are prevalent among rhesus monkeys. RRV can be efficiently propagated and grows to a high titer in cultured rhesus monkey fibroblasts, thus providing a valuable model to study the rhadinovirus replication. By comparative genomic studies, here we describe the identification of two potential transcriptional factors encoded by RRV, designated as R-Rta and R-bZIP. Initial functional characterization of these products suggested that R-Rta is a potent transcriptional activator and R-bZIP forms homodimers in vivo. Viral homologues of R-Rta and R-bZIP, previously identified from other rhadinoviruses, have been implicated in serving as molecular switches in lytic replication.
AB - Rhesus monkey rhadinovirus (RRV) is a γ2-herpesvirus identified from the peripheral blood mononuclear cells of rhesus macaques (Macaca mulatta). Serologic studies suggested that the infections of RRV are prevalent among rhesus monkeys. RRV can be efficiently propagated and grows to a high titer in cultured rhesus monkey fibroblasts, thus providing a valuable model to study the rhadinovirus replication. By comparative genomic studies, here we describe the identification of two potential transcriptional factors encoded by RRV, designated as R-Rta and R-bZIP. Initial functional characterization of these products suggested that R-Rta is a potent transcriptional activator and R-bZIP forms homodimers in vivo. Viral homologues of R-Rta and R-bZIP, previously identified from other rhadinoviruses, have been implicated in serving as molecular switches in lytic replication.
KW - bZIP
KW - KSHV
KW - Rhesus monkey rhadinovirus
KW - RNA splicing
KW - RRV
KW - Rta
UR - http://www.scopus.com/inward/record.url?scp=0036374978&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036374978&partnerID=8YFLogxK
U2 - 10.1006/viro.2002.1490
DO - 10.1006/viro.2002.1490
M3 - Article
C2 - 12127781
AN - SCOPUS:0036374978
VL - 298
SP - 181
EP - 188
JO - Virology
JF - Virology
SN - 0042-6822
IS - 2
ER -