Identification of novel mutations of TP53, ALK and RET gene in metastatic thymic squamous cell carcinoma and its therapeutic implication

Zhenli Hu, Jinghan Wang, Tony Yao, Ruey Long Hong, Keqiang Zhang, Hanlin Gao, Xiwei Wu, Jie Li, Chong Bai, Yun Yen

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Thymic tumors are epithelial tumors of the thymus for which multimodal therapies are often ineffective because of a lack of standardized regimens. Due to the low incidence, the molecular pathology and genomic abnormalities of thymic epithelial tumors are largely unknown. In this study, we report our comprehensively genomic study on a case of metastatic thymic tumor. Using next generation deep DNA sequencing technology, we sequenced 190 segments of 46 cancer genes of the cancer genome to cover 739 COSMIC mutations in 604 loci. Among these sequenced cancer genes, we identified that three low frequency (~10% of cells) mutations in the TP53 gene (c.782+1G. > T), ALK gene (c.3551C. > T), and RET gene (c.2651A. > T). To the best of our knowledge, this is the first study to show those mutations in thymic tumor. Of note, our study further indicates comprehensive molecular analysis may facilitate development of novel diagnostic and therapeutic strategies for thymic tumors.

Original languageEnglish
Pages (from-to)27-31
Number of pages5
JournalLung Cancer
Volume81
Issue number1
DOIs
Publication statusPublished - Jul 1 2013

Fingerprint

Thymus Neoplasms
Squamous Cell Carcinoma
Mutation
Neoplasm Genes
Genes
High-Throughput Nucleotide Sequencing
Molecular Pathology
p53 Genes
Therapeutics
DNA Sequence Analysis
Genome
Technology
Incidence
Neoplasms
Thymic epithelial tumor

Keywords

  • Gene mutation
  • Targeted therapy
  • Thymic tumor

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Cite this

Identification of novel mutations of TP53, ALK and RET gene in metastatic thymic squamous cell carcinoma and its therapeutic implication. / Hu, Zhenli; Wang, Jinghan; Yao, Tony; Hong, Ruey Long; Zhang, Keqiang; Gao, Hanlin; Wu, Xiwei; Li, Jie; Bai, Chong; Yen, Yun.

In: Lung Cancer, Vol. 81, No. 1, 01.07.2013, p. 27-31.

Research output: Contribution to journalReview article

Hu, Zhenli ; Wang, Jinghan ; Yao, Tony ; Hong, Ruey Long ; Zhang, Keqiang ; Gao, Hanlin ; Wu, Xiwei ; Li, Jie ; Bai, Chong ; Yen, Yun. / Identification of novel mutations of TP53, ALK and RET gene in metastatic thymic squamous cell carcinoma and its therapeutic implication. In: Lung Cancer. 2013 ; Vol. 81, No. 1. pp. 27-31.
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AU - Zhang, Keqiang

AU - Gao, Hanlin

AU - Wu, Xiwei

AU - Li, Jie

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AB - Thymic tumors are epithelial tumors of the thymus for which multimodal therapies are often ineffective because of a lack of standardized regimens. Due to the low incidence, the molecular pathology and genomic abnormalities of thymic epithelial tumors are largely unknown. In this study, we report our comprehensively genomic study on a case of metastatic thymic tumor. Using next generation deep DNA sequencing technology, we sequenced 190 segments of 46 cancer genes of the cancer genome to cover 739 COSMIC mutations in 604 loci. Among these sequenced cancer genes, we identified that three low frequency (~10% of cells) mutations in the TP53 gene (c.782+1G. > T), ALK gene (c.3551C. > T), and RET gene (c.2651A. > T). To the best of our knowledge, this is the first study to show those mutations in thymic tumor. Of note, our study further indicates comprehensive molecular analysis may facilitate development of novel diagnostic and therapeutic strategies for thymic tumors.

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