Identification of nilotinib-altered microRNA expression patterns in imatinib-resistant chronic myeloid leukemia cells

Medicine & Life Sciences

• 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide 100%
• Imatinib Mesylate 78%
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive 72%
• Myeloid Cells 70%
• MicroRNAs 58%
• K562 Cells 23%
• Circulating MicroRNA 13%
• Leukemia, Myeloid, Chronic Phase 13%
• Biomarkers 12%
• Pharmaceutical Preparations 12%
• Microarray Analysis 10%
• Hematologic Neoplasms 10%
• Treatment Failure 9%
• Drug Resistance 9%
• Therapeutics 8%
• Cell Culture Techniques 7%
• Neoplasms 6%

Chemical Compounds

• MicroRNA 84%
• Imatinib 38%
• Nilotinib 30%
• Biological Marker 15%
• Drug 13%
• Microarrays 9%
• Marker 7%
• Resistance 5%

Engineering & Materials Science

• Biomarkers 85%
• Microarrays 39%