Identification of melamine/cyanuric acid-containing nephrolithiasis by infrared spectroscopy

Wen Chi Chen, San Yuan Wu, Hsin Ping Liu, Chiao Hui Chang, Huey Yi Chen, Hsin Yi Chen, Chou Huang Tsai, Yi Chun Chang, Fuu Jen Tsai, Kee Ming Man, Po Len Liu, Feng Yen Lin, Jui Lung Shen, Wei Yong Lin, Yung Hsiang Chen

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Melamine-contaminated milk formula caused infant nephrolithiasis in some areas of China. Its combination with cyanuric acid causes crystallization in renal tubules. Following this renal damage and even renal failure that require long-term hemodialysis has been reported. Therefore, correct and timely diagnosis of these complex diseases is critical. Melamine containing stone is a combination of equal molar ratios of common stone compositions that has been reported from previous animal studies. We have previously identified the compositions of urinary tract stones with infrared (IR) spectroscopy. We hypothesized that the absorbance of wavelength of IR can identify melamine/cyanuric acid in the presence of mixing human stone compositions. In this study, we made an artificial stone composition and examine under IR absorbance by mixing equal molar ratios of melamine/cyanuric acid with different types of human urinary stones, and established a reference of IR analysis for the identification of melamine/cyanuric acid-containing human urinary tract stones. Knowledge of the precise stone composition allowed institution of appropriate prophylactic dietary and medical therapy and this may help in the prevention of urinary stone recurrence. The results are promising that melamine and cyanuric acid can be identified clearly in a low percentile (∼1%) of stone mixture pellet. Therefore, IR seems to be an ideal tool for the identification of melamine/cyanuric acid-containing stones.

Original languageEnglish
Pages (from-to)92-99
Number of pages8
JournalJournal of Clinical Laboratory Analysis
Volume24
Issue number2
DOIs
Publication statusPublished - Mar 2010
Externally publishedYes

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Nephrolithiasis
Infrared spectroscopy
Spectrum Analysis
Urinary Calculi
Infrared radiation
Chemical analysis
Kidney
Infant Formula
Crystallization
cyanuric acid
melamine
Renal Insufficiency
Renal Dialysis
China
Milk
Animals
Recurrence
Wavelength

Keywords

  • Cyanuric acid
  • Infrared spectroscopy
  • Melamine
  • Nephrolithiasis
  • Urinary stone analysis

ASJC Scopus subject areas

  • Medical Laboratory Technology
  • Microbiology (medical)
  • Immunology and Allergy
  • Hematology
  • Public Health, Environmental and Occupational Health
  • Biochemistry, medical
  • Clinical Biochemistry

Cite this

Chen, W. C., Wu, S. Y., Liu, H. P., Chang, C. H., Chen, H. Y., Chen, H. Y., ... Chen, Y. H. (2010). Identification of melamine/cyanuric acid-containing nephrolithiasis by infrared spectroscopy. Journal of Clinical Laboratory Analysis, 24(2), 92-99. https://doi.org/10.1002/jcla.20362

Identification of melamine/cyanuric acid-containing nephrolithiasis by infrared spectroscopy. / Chen, Wen Chi; Wu, San Yuan; Liu, Hsin Ping; Chang, Chiao Hui; Chen, Huey Yi; Chen, Hsin Yi; Tsai, Chou Huang; Chang, Yi Chun; Tsai, Fuu Jen; Man, Kee Ming; Liu, Po Len; Lin, Feng Yen; Shen, Jui Lung; Lin, Wei Yong; Chen, Yung Hsiang.

In: Journal of Clinical Laboratory Analysis, Vol. 24, No. 2, 03.2010, p. 92-99.

Research output: Contribution to journalArticle

Chen, WC, Wu, SY, Liu, HP, Chang, CH, Chen, HY, Chen, HY, Tsai, CH, Chang, YC, Tsai, FJ, Man, KM, Liu, PL, Lin, FY, Shen, JL, Lin, WY & Chen, YH 2010, 'Identification of melamine/cyanuric acid-containing nephrolithiasis by infrared spectroscopy', Journal of Clinical Laboratory Analysis, vol. 24, no. 2, pp. 92-99. https://doi.org/10.1002/jcla.20362
Chen, Wen Chi ; Wu, San Yuan ; Liu, Hsin Ping ; Chang, Chiao Hui ; Chen, Huey Yi ; Chen, Hsin Yi ; Tsai, Chou Huang ; Chang, Yi Chun ; Tsai, Fuu Jen ; Man, Kee Ming ; Liu, Po Len ; Lin, Feng Yen ; Shen, Jui Lung ; Lin, Wei Yong ; Chen, Yung Hsiang. / Identification of melamine/cyanuric acid-containing nephrolithiasis by infrared spectroscopy. In: Journal of Clinical Laboratory Analysis. 2010 ; Vol. 24, No. 2. pp. 92-99.
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