Identification of flurbiprofen and its photoproducts in methanol by gas chromatography-mass spectrometry

Su Hui Chao, Hsin Tsung Ho, Fu An Chen, Pen Yuan Lin, Yi Chun Yu, An-Bang Wu

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A sample of 10 mM flurbiprofen in methanol (or ethanol) was photoirradiated with sixteen 8 W low-pressure quartz mercury lamps irradiated at 306 nm in a Panchum PR-2000 photochemical reactor. In total, four major photoproducts derived from each sample were observed from the HPLC chromatogram. The photoproducts were separated and their structures elucidated by various spectroscopic methods. Alternatively, using GC-MS, 11 major photoproducts were observed. A reaction scheme of flurbiprofen in methanol is proposed: the photochemical reaction routes occur mainly via esterification and decarboxylation, followed by oxidation with singlet oxygen to produce a ketone, alcohols and other derivatives.

Original languageEnglish
Pages (from-to)527-533
Number of pages7
JournalBiomedical Chromatography
Volume21
Issue number5
DOIs
Publication statusPublished - May 2007

Fingerprint

Flurbiprofen
Gas chromatography
Gas Chromatography-Mass Spectrometry
Mass spectrometry
Methanol
Mercury vapor lamps
Singlet Oxygen
Decarboxylation
Quartz
Esterification
Photochemical reactions
Ketones
Mercury
Ethanol
High Pressure Liquid Chromatography
Alcohols
Derivatives
Pressure
Oxidation

Keywords

  • Flurbiprofen
  • GC-MS
  • HPLC
  • Photoproducts

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Pharmacology

Cite this

Identification of flurbiprofen and its photoproducts in methanol by gas chromatography-mass spectrometry. / Chao, Su Hui; Ho, Hsin Tsung; Chen, Fu An; Lin, Pen Yuan; Yu, Yi Chun; Wu, An-Bang.

In: Biomedical Chromatography, Vol. 21, No. 5, 05.2007, p. 527-533.

Research output: Contribution to journalArticle

Chao, Su Hui ; Ho, Hsin Tsung ; Chen, Fu An ; Lin, Pen Yuan ; Yu, Yi Chun ; Wu, An-Bang. / Identification of flurbiprofen and its photoproducts in methanol by gas chromatography-mass spectrometry. In: Biomedical Chromatography. 2007 ; Vol. 21, No. 5. pp. 527-533.
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