10 Citations (Scopus)

Abstract

Background: Glycine N-methyltransferase (GNMT) is a tumor suppressor of hepatocellular carcinoma (HCC). High proportions of GNMT knockout mice developed HCC. We previously identified a potential novel marker from Gnmt knockout mice, FK506 binding protein 11 (FKBP11). Here, we determined the clinical usefulness of FKBP11. Patients and Methods: FKBP11 expression levels were analyzed in 123 paired tumor and tumor-Adjacent non-tumorous (TA) tissue samples from patients with HCC and in 29 benign liver samples from patients with hemangioma using quantitative real-time polymerase-chain-reaction. Results: FKBP11 was expressed at a higher level in tumor tissues compared to TA tissues (p

Original languageEnglish
Pages (from-to)2763-2770
Number of pages8
JournalAnticancer Research
Volume33
Issue number6
Publication statusPublished - Jun 2013

Keywords

  • FK506 binding protein
  • FKBP11
  • FKBP19
  • GNMT
  • HCC

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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