7 Citations (Scopus)

Abstract

Background: Glycine N-methyltransferase (GNMT) is a tumor suppressor of hepatocellular carcinoma (HCC). High proportions of GNMT knockout mice developed HCC. We previously identified a potential novel marker from Gnmt knockout mice, FK506 binding protein 11 (FKBP11). Here, we determined the clinical usefulness of FKBP11. Patients and Methods: FKBP11 expression levels were analyzed in 123 paired tumor and tumor-Adjacent non-tumorous (TA) tissue samples from patients with HCC and in 29 benign liver samples from patients with hemangioma using quantitative real-time polymerase-chain-reaction. Results: FKBP11 was expressed at a higher level in tumor tissues compared to TA tissues (p

Original languageEnglish
Pages (from-to)2763-2770
Number of pages8
JournalAnticancer Research
Volume33
Issue number6
Publication statusPublished - Jun 2013

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Tacrolimus Binding Proteins
Glycine N-Methyltransferase
Hepatocellular Carcinoma
Biomarkers
Knockout Mice
Neoplasms
Hemangioma
Real-Time Polymerase Chain Reaction
Liver

Keywords

  • FK506 binding protein
  • FKBP11
  • FKBP19
  • GNMT
  • HCC

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Identification of FKBP11 as a biomarker for hepatocellular carcinoma. / Lin, I. Yin; Yen, Chia Hung; Liao, Yi Jen; Lin, Sey-En; Ma, Hon Ping; Chan, Yu Jiun; Chen, Yi Ming A.

In: Anticancer Research, Vol. 33, No. 6, 06.2013, p. 2763-2770.

Research output: Contribution to journalArticle

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author = "Lin, {I. Yin} and Yen, {Chia Hung} and Liao, {Yi Jen} and Sey-En Lin and Ma, {Hon Ping} and Chan, {Yu Jiun} and Chen, {Yi Ming A}",
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T1 - Identification of FKBP11 as a biomarker for hepatocellular carcinoma

AU - Lin, I. Yin

AU - Yen, Chia Hung

AU - Liao, Yi Jen

AU - Lin, Sey-En

AU - Ma, Hon Ping

AU - Chan, Yu Jiun

AU - Chen, Yi Ming A

PY - 2013/6

Y1 - 2013/6

N2 - Background: Glycine N-methyltransferase (GNMT) is a tumor suppressor of hepatocellular carcinoma (HCC). High proportions of GNMT knockout mice developed HCC. We previously identified a potential novel marker from Gnmt knockout mice, FK506 binding protein 11 (FKBP11). Here, we determined the clinical usefulness of FKBP11. Patients and Methods: FKBP11 expression levels were analyzed in 123 paired tumor and tumor-Adjacent non-tumorous (TA) tissue samples from patients with HCC and in 29 benign liver samples from patients with hemangioma using quantitative real-time polymerase-chain-reaction. Results: FKBP11 was expressed at a higher level in tumor tissues compared to TA tissues (p

AB - Background: Glycine N-methyltransferase (GNMT) is a tumor suppressor of hepatocellular carcinoma (HCC). High proportions of GNMT knockout mice developed HCC. We previously identified a potential novel marker from Gnmt knockout mice, FK506 binding protein 11 (FKBP11). Here, we determined the clinical usefulness of FKBP11. Patients and Methods: FKBP11 expression levels were analyzed in 123 paired tumor and tumor-Adjacent non-tumorous (TA) tissue samples from patients with HCC and in 29 benign liver samples from patients with hemangioma using quantitative real-time polymerase-chain-reaction. Results: FKBP11 was expressed at a higher level in tumor tissues compared to TA tissues (p

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