Icodextrin decreases technique failure and improves patient survival in peritoneal dialysis patients

I. Kuan Wang, Yu Fen Li, Jin Hua Chen, Chih Chia Liang, Yao Lung Liu, Hsin Hung Lin, Chiz Tzung Chang, Wen Chen Tsai, Tzung Hai Yen, Chiu Ching Huang

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Abstract

Aim It remains unclear whether long-term daily icodextrin use can decrease technique failure and improve survival in peritoneal dialysis (PD) patients. The aim of the present study was to investigate whether icodextrin use, once daily, can decrease technique failure and prolong patient survival in incident PD patients. Methods Incident PD patients who survived more than 90 days were recruited from the China Medical University Hospital, Taiwan, between 1 January 2007 and 31 December 2011. All patients were followed until transfer to haemodialysis (HD), renal transplantation, transfer to another centre, death, or 31 December 2011. Results A total of 306 incident PD patients (89 icodextrin users, 217 icodextrin non-users) were recruited during the study period. Icodextrin users were more likely to have hypertension, diabetes and high or high-average peritoneal transport compared with non-users. During the follow-up period, 43 patients were transferred to HD: seven (7.87%) of the icodextrin group, and 36 (16.59%) of the non-icodextrin group. Thirty-two patients died during the follow-up period: five (5.62%) of the icodextrin group, and 27 (12.44%) of the non-icodextrin group. Icodextrin use was significantly associated with a better prognosis, in terms of technique failure (adjusted HR = 0.32; 95% CI = 0.14-0.72). With regard to patient survival, icodextrin use (adjusted HR = 0.33; 95% CI = 0.12-0.87) was associated with a significantly lower risk of death. Conclusion The use of icodextrin once daily may decrease technique failure and improve survival in incident PD patients.

Original languageEnglish
Pages (from-to)161-167
Number of pages7
JournalNephrology
Volume20
Issue number3
DOIs
Publication statusPublished - Mar 1 2015

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Keywords

  • End-stage renal disease
  • icodextrin
  • patient survival
  • peritoneal dialysis
  • technique survival

ASJC Scopus subject areas

  • Nephrology

Cite this

Wang, I. K., Li, Y. F., Chen, J. H., Liang, C. C., Liu, Y. L., Lin, H. H., Chang, C. T., Tsai, W. C., Yen, T. H., & Huang, C. C. (2015). Icodextrin decreases technique failure and improves patient survival in peritoneal dialysis patients. Nephrology, 20(3), 161-167. https://doi.org/10.1111/nep.12375