Hypoxia inducible factor-1alpha gene polymorphism G1790A and its interaction with tobacco and alcohol consumptions increase susceptibility to hepatocellular carcinoma.

Pei Ching Hsiao, Mu Kuan Chen, Shih Chi Su, Kwo Chang Ueng, Yi Chen Chen, Yi Hsien Hsieh, Yu Fan Liu, Hsiu Ting Tsai, Shun Fa Yang

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Background and Objectives: The aim of this study was to examine the potential associations of two hypoxia inducible factor-1α (HIF-1α) gene polymorphisms, C1772T and G1790A, with the susceptibility and clinicopathological status of hepatocellular carcinoma. Methods: A total of 449 subjects, including 347 healthy controls and 102 patients with hepatocellular carcinoma, were recruited in this study and subjected to polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analyses to estimate the impact of these two polymorphic variants on hepatocellular carcinoma. Results: G1790A heterozygotes showed a higher risk for hepatocellular carcinoma, compared with GG genotypes after adjusting for other confounders (AOR = 3.97; 95%CI = 1.70-9.22), indicating a significant association between hepatocellular carcinoma susceptibility and G1790A polymorphism. Moreover, results also revealed the presence of synergistic effect between gene polymorphism of HIF-1α G1790A and environmental risk factors, such as tobacco and alcohol consumptions while there was no significant association between HIF-1α gene polymorphism and clinicopathological parameters of hepatocellular carcinoma. Conclusions: Genetic polymorphism at G1790A of HIF-1α is an important factor for determining the susceptibility to hepatocellular carcinoma. The interaction effects of G1790A heterozygotes to tobacco and to alcohol consumption significantly increase the risk to develop hepatocellular carcinoma.

Original languageEnglish
Pages (from-to)163-169
Number of pages7
JournalJournal of Surgical Oncology
Volume102
Issue number2
DOIs
Publication statusPublished - Aug 1 2010
Externally publishedYes

Fingerprint

Tobacco Use
Alcohol Drinking
Hepatocellular Carcinoma
Hypoxia-Inducible Factor 1
Genes
Heterozygote
Hypoxia
Genetic Polymorphisms
Restriction Fragment Length Polymorphisms
Tobacco
Genotype
Polymerase Chain Reaction

Keywords

  • Hepatocellular carcinoma
  • Hypoxia inducible factor-1α
  • Polymorphism

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Hypoxia inducible factor-1alpha gene polymorphism G1790A and its interaction with tobacco and alcohol consumptions increase susceptibility to hepatocellular carcinoma. / Hsiao, Pei Ching; Chen, Mu Kuan; Su, Shih Chi; Ueng, Kwo Chang; Chen, Yi Chen; Hsieh, Yi Hsien; Liu, Yu Fan; Tsai, Hsiu Ting; Yang, Shun Fa.

In: Journal of Surgical Oncology, Vol. 102, No. 2, 01.08.2010, p. 163-169.

Research output: Contribution to journalArticle

Hsiao, Pei Ching ; Chen, Mu Kuan ; Su, Shih Chi ; Ueng, Kwo Chang ; Chen, Yi Chen ; Hsieh, Yi Hsien ; Liu, Yu Fan ; Tsai, Hsiu Ting ; Yang, Shun Fa. / Hypoxia inducible factor-1alpha gene polymorphism G1790A and its interaction with tobacco and alcohol consumptions increase susceptibility to hepatocellular carcinoma. In: Journal of Surgical Oncology. 2010 ; Vol. 102, No. 2. pp. 163-169.
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