Abstract
Vescalagin, an active component from Pink wax apple [Syzygium samarangense (Blume) Merrill and Perry cv. Pink] fruit, with glucose uptake enhancing ability in insulin-resistant FL83B mouse hepatocytes, as shown in our previous study, was further evaluated for its hypotriglyceridemic and hypoglycemic effects in high-fructose diet (HFD)-induced diabetic rats. Wistar rats were fed HFD for 16 weeks and orally administered with vescalagin from Pink wax apple daily during the last 4 weeks. The results of biochemical parameters showed that fasting blood glucose, C-peptide, fructosamine, triglyceride and free fatty acid contents decreased by 44.7%, 46.2%, 4.0%, 42.5%, and 10.8%, respectively, in the HFD-induced diabetic rats administered with vescalagin at 30 mg/kg body weight in comparison with those of control HFD-induced diabetic rats. However, high-density-lipoprotein-cholesterol content increased by 14.4% in the HFD rats treated with vescalagin. The present study reveals that vescalagin could have therapeutic value against diabetic progression via its anti-hypertriglyceridemic and anti-hyperglycemic effects.
| Original language | English |
|---|---|
| Pages (from-to) | 858-863 |
| Number of pages | 6 |
| Journal | Food Chemistry |
| Volume | 136 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 15 2013 |
| Externally published | Yes |
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Keywords
- Diabetic progression
- Hypoglycemia
- Hypotriglyceridemia
- Pink wax apple
- Vescalagin
ASJC Scopus subject areas
- Analytical Chemistry
- Food Science
Cite this
Hypotriglyceridemic and hypoglycemic effects of vescalagin from Pink wax apple [Syzygium samarangense (Blume) Merrill and Perry cv. Pink] in high-fructose diet-induced diabetic rats. / Shen, Szu Chuan; Chang, Wen Chang.
In: Food Chemistry, Vol. 136, No. 2, 15.01.2013, p. 858-863.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hypotriglyceridemic and hypoglycemic effects of vescalagin from Pink wax apple [Syzygium samarangense (Blume) Merrill and Perry cv. Pink] in high-fructose diet-induced diabetic rats
AU - Shen, Szu Chuan
AU - Chang, Wen Chang
PY - 2013/1/15
Y1 - 2013/1/15
N2 - Vescalagin, an active component from Pink wax apple [Syzygium samarangense (Blume) Merrill and Perry cv. Pink] fruit, with glucose uptake enhancing ability in insulin-resistant FL83B mouse hepatocytes, as shown in our previous study, was further evaluated for its hypotriglyceridemic and hypoglycemic effects in high-fructose diet (HFD)-induced diabetic rats. Wistar rats were fed HFD for 16 weeks and orally administered with vescalagin from Pink wax apple daily during the last 4 weeks. The results of biochemical parameters showed that fasting blood glucose, C-peptide, fructosamine, triglyceride and free fatty acid contents decreased by 44.7%, 46.2%, 4.0%, 42.5%, and 10.8%, respectively, in the HFD-induced diabetic rats administered with vescalagin at 30 mg/kg body weight in comparison with those of control HFD-induced diabetic rats. However, high-density-lipoprotein-cholesterol content increased by 14.4% in the HFD rats treated with vescalagin. The present study reveals that vescalagin could have therapeutic value against diabetic progression via its anti-hypertriglyceridemic and anti-hyperglycemic effects.
AB - Vescalagin, an active component from Pink wax apple [Syzygium samarangense (Blume) Merrill and Perry cv. Pink] fruit, with glucose uptake enhancing ability in insulin-resistant FL83B mouse hepatocytes, as shown in our previous study, was further evaluated for its hypotriglyceridemic and hypoglycemic effects in high-fructose diet (HFD)-induced diabetic rats. Wistar rats were fed HFD for 16 weeks and orally administered with vescalagin from Pink wax apple daily during the last 4 weeks. The results of biochemical parameters showed that fasting blood glucose, C-peptide, fructosamine, triglyceride and free fatty acid contents decreased by 44.7%, 46.2%, 4.0%, 42.5%, and 10.8%, respectively, in the HFD-induced diabetic rats administered with vescalagin at 30 mg/kg body weight in comparison with those of control HFD-induced diabetic rats. However, high-density-lipoprotein-cholesterol content increased by 14.4% in the HFD rats treated with vescalagin. The present study reveals that vescalagin could have therapeutic value against diabetic progression via its anti-hypertriglyceridemic and anti-hyperglycemic effects.
KW - Diabetic progression
KW - Hypoglycemia
KW - Hypotriglyceridemia
KW - Pink wax apple
KW - Vescalagin
UR - http://www.scopus.com/inward/record.url?scp=84866870819&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866870819&partnerID=8YFLogxK
U2 - 10.1016/j.foodchem.2012.08.037
DO - 10.1016/j.foodchem.2012.08.037
M3 - Article
C2 - 23122137
AN - SCOPUS:84866870819
VL - 136
SP - 858
EP - 863
JO - Food Chemistry
JF - Food Chemistry
SN - 0308-8146
IS - 2
ER -