Hypolipidemic effects and safety of Lactobacillus Reuteri 263 in a hamster model of hyperlipidemia

Wen Ching Huang, Yi Ming Chen, Nai Wen Kan, Chun Sheng Ho, Li Wei, Ching Hung Chan, Hui Yu Huang, Chi Chang Huang

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We aimed to verify the beneficial effects of probiotic strain Lactobacillus reuteri 263 (Lr263) on hypolipidemic action in hamsters with hyperlipidemia induced by a 0.2% cholesterol and 10% lard diet (i.e., high-cholesterol diet (HCD)). Male Golden Syrian hamsters were randomly divided into two groups: normal (n = 8), standard diet (control), and experimental (n = 32), a HCD. After a two-week induction followed by a six-week supplementation with Lr263, the 32 hyperlipidemic hamsters were divided into four groups (n = 8 per group) to receive vehicle or Lr263 by oral gavage at 2.1, 4.2, or 10.5 × 109 cells/kg/day for 6 weeks, designated the HCD, 1X, 2X and 5X groups, respectively. The efficacy and safety of Lr263 supplementation were evaluated by lipid profiles of serum, liver and feces and by clinical biochemistry and histopathology. HCD significantly increased serum levels of total cholesterol (TC), triacylglycerol (TG) cholesterol, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), LDL-C/HDL-C ratio, hepatic and fetal TC and TG levels, and degree of fatty liver as compared with controls. Lr263 supplementation dose dependently increased serum HDL-C level and decreased serum TC, TG, LDL-C levels, LDL-C/HDL-C ratio, hepatic TC and TG levels, and fecal TG level. In addition, Lr263 supplementation had few subchronic toxic effects. Lr263 could be a potential agent with a hypolipidemic pharmacological effect.

Original languageEnglish
Pages (from-to)3767-3782
Number of pages16
JournalNutrients
Volume7
Issue number5
DOIs
Publication statusPublished - May 15 2015

Keywords

  • Cholesterol
  • High-cholesterol diet
  • Hypolipidemic
  • Lipid-lowering
  • Triglyceride

ASJC Scopus subject areas

  • Food Science

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