Hypolipidemic effect of tomato juice in hamsters in high cholesterol diet-induced hyperlipidemia

Li Chen Lee, Li Wei, Wen Ching Huang, Yi Ju Hsu, Yi Ming Chen, Chi Chang Huang

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Tomato is a globally famous food and contains several phytonutrients including lycopene,β-carotene, anthocyanin, and flavonoids. The increased temperature used to produce tomato juice, ketchup, tomato paste and canned tomato enhances the bioactive composition. We aimed to verify the beneficial effects of processed tomato juice from Kagome Ltd. (KOT) on hypolipidemic action in hamsters with hyperlipidemia induced by a 0.2% cholesterol and 10% lard diet (i.e., high-cholesterol diet (HCD)). Male Golden Syrian hamsters were randomly divided into two groups for treatment: normal (n = 8), standard diet (control); and experimental (n = 32), HCD. The 32 hamsters were further divided into four groups (n = 8 per group) to receive vehicle or KOT by oral gavage at 2787, 5573, or 13,934 mg/kg/day for six weeks, designated the HCD-1X, -2X and -5X groups, respectively. The efficacy and safety of KOT supplementation was evaluated by lipid profiles of serum, liver and feces and by clinical biochemistry and histopathology. HCD significantly increased serum levels of total cholesterol (TC), triacylglycerol (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), LDL-C/HDL-C ratio, hepatic and fetal TC and TG levels, and degree of fatty liver as compared with controls. KOT supplementation dose-dependently decreased serum TC, TG, LDL-C levels, LDL-C/HDL-C ratio, hepatic TC and TG levels, and fecal TG level. Our study provides experiment-based evidence to support that KOT may be useful in treating or preventing the onset of hyperlipidemia.

Original languageEnglish
Pages (from-to)10525-10537
Number of pages13
JournalNutrients
Volume7
Issue number12
DOIs
Publication statusPublished - Dec 17 2015

Fingerprint

tomato juice
hyperlipidemia
Lycopersicon esculentum
high fat diet
Hyperlipidemias
hamsters
Cricetinae
low density lipoprotein cholesterol
triacylglycerols
Cholesterol
cholesterol
Diet
high density lipoprotein cholesterol
Triglycerides
LDL Cholesterol
liver
HDL Cholesterol
ketchup
tomatoes
tomato paste

Keywords

  • Cholesterol
  • High-cholesterol diet
  • Hypolipidemic
  • Lipid-lowering
  • Tomato juice
  • Triglyceride

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Lee, L. C., Wei, L., Huang, W. C., Hsu, Y. J., Chen, Y. M., & Huang, C. C. (2015). Hypolipidemic effect of tomato juice in hamsters in high cholesterol diet-induced hyperlipidemia. Nutrients, 7(12), 10525-10537. https://doi.org/10.3390/nu7125552

Hypolipidemic effect of tomato juice in hamsters in high cholesterol diet-induced hyperlipidemia. / Lee, Li Chen; Wei, Li; Huang, Wen Ching; Hsu, Yi Ju; Chen, Yi Ming; Huang, Chi Chang.

In: Nutrients, Vol. 7, No. 12, 17.12.2015, p. 10525-10537.

Research output: Contribution to journalArticle

Lee, LC, Wei, L, Huang, WC, Hsu, YJ, Chen, YM & Huang, CC 2015, 'Hypolipidemic effect of tomato juice in hamsters in high cholesterol diet-induced hyperlipidemia', Nutrients, vol. 7, no. 12, pp. 10525-10537. https://doi.org/10.3390/nu7125552
Lee, Li Chen ; Wei, Li ; Huang, Wen Ching ; Hsu, Yi Ju ; Chen, Yi Ming ; Huang, Chi Chang. / Hypolipidemic effect of tomato juice in hamsters in high cholesterol diet-induced hyperlipidemia. In: Nutrients. 2015 ; Vol. 7, No. 12. pp. 10525-10537.
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