Hypofractionated CyberKnife stereotactic radiosurgery for acoustic neuromas with and without association to neurofibromatosis Type 2

D. T. Ju, J. W. Lin, M. S. Lin, L. M. Lee, H. M. Tseng, C. P. Wei, C. H. Yen, C. C. Hung, K. S. Hung, C. M. Lin, Tien-Jen Lin, W. T. Chiu, Jo Ting Tsai

Research output: Chapter in Book/Report/Conference proceedingChapter

18 Citations (Scopus)

Abstract

CyberKnife stereotactic radiosurgery (CKSRS) has been proved effective in treating intra-cranial lesions. To treat acoustic neuroma (AN) patients with or without neurofibromatosis Type 2 (NF2) associations, the functional preservation of hearing, trigeminal nerve, and facial nerve are important. Twenty-one patients were treated with hypofractionated CKSRS. Fourteen non-NF2 and seven NF2 patients were enrolled. Cranial nerve function, audiograms, and magnetic resonance images (MRI) were monitored. Mean follow-up was 15 month. Tumors with volumes ranging from 0.13 to 24.8 cm3 (mean 5.4 cm3) were irradiated with the marginal dose 1800-2000 cGy/3 fractions. Tumors were treated with an 80 to 89% isodose line (mean 83%) and mean 97.9% tumor coverage. Two patients experienced hearing deterioration (16.7%) in the non-NF2 group, and 3 patients (50%) in the NF2 group. No facial or trigeminal dysfunction, brain stem toxicity, or cerebellar edema occurred. Tumor regression was seen in 9 patients (43%) and stable in 12 patients (57%). 100% tumor control rate was achieved. Hypofractionated CKSRS was not only effective in tumor control but also excellent in hearing preservation for non-NF2 AN. But for NF2 patients, although the tumor control was remarkable, hearing preservation was modest as in non-NF2 patients.

Original languageEnglish
Title of host publicationReconstructive Neurosurgery
PublisherSpringer-Verlag Wien
Pages169-173
Number of pages5
Edition101
ISBN (Print)9783211782040
DOIs
Publication statusPublished - Jan 1 2008

Publication series

NameActa Neurochirurgica, Supplementum
Number101
ISSN (Print)0065-1419

Fingerprint

Neurofibromatosis 2
Acoustic Neuroma
Radiosurgery
Hearing
Neoplasms
Trigeminal Nerve
Cranial Nerves
Facial Nerve
Tumor Burden
Brain Stem
Edema
Magnetic Resonance Spectroscopy

Keywords

  • Acoustic neuroma
  • CyberKnife (CK)
  • hypofraction
  • neurofibromatosis Type 2 (NF2)
  • stereotactic radiosurgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Ju, D. T., Lin, J. W., Lin, M. S., Lee, L. M., Tseng, H. M., Wei, C. P., ... Tsai, J. T. (2008). Hypofractionated CyberKnife stereotactic radiosurgery for acoustic neuromas with and without association to neurofibromatosis Type 2. In Reconstructive Neurosurgery (101 ed., pp. 169-173). (Acta Neurochirurgica, Supplementum; No. 101). Springer-Verlag Wien. https://doi.org/10.1007/978-3-211-78205-7_29

Hypofractionated CyberKnife stereotactic radiosurgery for acoustic neuromas with and without association to neurofibromatosis Type 2. / Ju, D. T.; Lin, J. W.; Lin, M. S.; Lee, L. M.; Tseng, H. M.; Wei, C. P.; Yen, C. H.; Hung, C. C.; Hung, K. S.; Lin, C. M.; Lin, Tien-Jen; Chiu, W. T.; Tsai, Jo Ting.

Reconstructive Neurosurgery. 101. ed. Springer-Verlag Wien, 2008. p. 169-173 (Acta Neurochirurgica, Supplementum; No. 101).

Research output: Chapter in Book/Report/Conference proceedingChapter

Ju, DT, Lin, JW, Lin, MS, Lee, LM, Tseng, HM, Wei, CP, Yen, CH, Hung, CC, Hung, KS, Lin, CM, Lin, T-J, Chiu, WT & Tsai, JT 2008, Hypofractionated CyberKnife stereotactic radiosurgery for acoustic neuromas with and without association to neurofibromatosis Type 2. in Reconstructive Neurosurgery. 101 edn, Acta Neurochirurgica, Supplementum, no. 101, Springer-Verlag Wien, pp. 169-173. https://doi.org/10.1007/978-3-211-78205-7_29
Ju DT, Lin JW, Lin MS, Lee LM, Tseng HM, Wei CP et al. Hypofractionated CyberKnife stereotactic radiosurgery for acoustic neuromas with and without association to neurofibromatosis Type 2. In Reconstructive Neurosurgery. 101 ed. Springer-Verlag Wien. 2008. p. 169-173. (Acta Neurochirurgica, Supplementum; 101). https://doi.org/10.1007/978-3-211-78205-7_29
Ju, D. T. ; Lin, J. W. ; Lin, M. S. ; Lee, L. M. ; Tseng, H. M. ; Wei, C. P. ; Yen, C. H. ; Hung, C. C. ; Hung, K. S. ; Lin, C. M. ; Lin, Tien-Jen ; Chiu, W. T. ; Tsai, Jo Ting. / Hypofractionated CyberKnife stereotactic radiosurgery for acoustic neuromas with and without association to neurofibromatosis Type 2. Reconstructive Neurosurgery. 101. ed. Springer-Verlag Wien, 2008. pp. 169-173 (Acta Neurochirurgica, Supplementum; 101).
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