Abstract
CyberKnife stereotactic radiosurgery (CKSRS) has been proved effective in treating intra-cranial lesions. To treat acoustic neuroma (AN) patients with or without neurofibromatosis Type 2 (NF2) associations, the functional preservation of hearing, trigeminal nerve, and facial nerve are important. Twenty-one patients were treated with hypofractionated CKSRS. Fourteen non-NF2 and seven NF2 patients were enrolled. Cranial nerve function, audiograms, and magnetic resonance images (MRI) were monitored. Mean follow-up was 15 month. Tumors with volumes ranging from 0.13 to 24.8 cm3 (mean 5.4 cm3) were irradiated with the marginal dose 1800-2000 cGy/3 fractions. Tumors were treated with an 80 to 89% isodose line (mean 83%) and mean 97.9% tumor coverage. Two patients experienced hearing deterioration (16.7%) in the non-NF2 group, and 3 patients (50%) in the NF2 group. No facial or trigeminal dysfunction, brain stem toxicity, or cerebellar edema occurred. Tumor regression was seen in 9 patients (43%) and stable in 12 patients (57%). 100% tumor control rate was achieved. Hypofractionated CKSRS was not only effective in tumor control but also excellent in hearing preservation for non-NF2 AN. But for NF2 patients, although the tumor control was remarkable, hearing preservation was modest as in non-NF2 patients.
| Original language | English |
|---|---|
| Title of host publication | Acta Neurochirurgica, Supplementum |
| Pages | 169-173 |
| Number of pages | 5 |
| Edition | 101 |
| DOIs | |
| Publication status | Published - 2008 |
Publication series
| Name | Acta Neurochirurgica, Supplementum |
|---|---|
| Number | 101 |
| ISSN (Print) | 00651419 |
Fingerprint
Keywords
- Acoustic neuroma
- CyberKnife (CK)
- hypofraction
- neurofibromatosis Type 2 (NF2)
- stereotactic radiosurgery
ASJC Scopus subject areas
- Clinical Neurology
- Surgery
Cite this
Hypofractionated CyberKnife stereotactic radiosurgery for acoustic neuromas with and without association to neurofibromatosis Type 2. / Ju, Da Tong; Lin, Jia Wei; Lin, Muh Shi; Lee, Liang Ming; Tseng, Ham Min; Wei, Chih Peng; Yen, Che Hung; Hung, Ching Chang; Hung, Kuo Sheng; Lin, Chien Min; Lin, T. J.; Chiu, Wen Ta; Tsai, Jo Ting.
Acta Neurochirurgica, Supplementum. 101. ed. 2008. p. 169-173 (Acta Neurochirurgica, Supplementum; No. 101).Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Hypofractionated CyberKnife stereotactic radiosurgery for acoustic neuromas with and without association to neurofibromatosis Type 2
AU - Ju, Da Tong
AU - Lin, Jia Wei
AU - Lin, Muh Shi
AU - Lee, Liang Ming
AU - Tseng, Ham Min
AU - Wei, Chih Peng
AU - Yen, Che Hung
AU - Hung, Ching Chang
AU - Hung, Kuo Sheng
AU - Lin, Chien Min
AU - Lin, T. J.
AU - Chiu, Wen Ta
AU - Tsai, Jo Ting
PY - 2008
Y1 - 2008
N2 - CyberKnife stereotactic radiosurgery (CKSRS) has been proved effective in treating intra-cranial lesions. To treat acoustic neuroma (AN) patients with or without neurofibromatosis Type 2 (NF2) associations, the functional preservation of hearing, trigeminal nerve, and facial nerve are important. Twenty-one patients were treated with hypofractionated CKSRS. Fourteen non-NF2 and seven NF2 patients were enrolled. Cranial nerve function, audiograms, and magnetic resonance images (MRI) were monitored. Mean follow-up was 15 month. Tumors with volumes ranging from 0.13 to 24.8 cm3 (mean 5.4 cm3) were irradiated with the marginal dose 1800-2000 cGy/3 fractions. Tumors were treated with an 80 to 89% isodose line (mean 83%) and mean 97.9% tumor coverage. Two patients experienced hearing deterioration (16.7%) in the non-NF2 group, and 3 patients (50%) in the NF2 group. No facial or trigeminal dysfunction, brain stem toxicity, or cerebellar edema occurred. Tumor regression was seen in 9 patients (43%) and stable in 12 patients (57%). 100% tumor control rate was achieved. Hypofractionated CKSRS was not only effective in tumor control but also excellent in hearing preservation for non-NF2 AN. But for NF2 patients, although the tumor control was remarkable, hearing preservation was modest as in non-NF2 patients.
AB - CyberKnife stereotactic radiosurgery (CKSRS) has been proved effective in treating intra-cranial lesions. To treat acoustic neuroma (AN) patients with or without neurofibromatosis Type 2 (NF2) associations, the functional preservation of hearing, trigeminal nerve, and facial nerve are important. Twenty-one patients were treated with hypofractionated CKSRS. Fourteen non-NF2 and seven NF2 patients were enrolled. Cranial nerve function, audiograms, and magnetic resonance images (MRI) were monitored. Mean follow-up was 15 month. Tumors with volumes ranging from 0.13 to 24.8 cm3 (mean 5.4 cm3) were irradiated with the marginal dose 1800-2000 cGy/3 fractions. Tumors were treated with an 80 to 89% isodose line (mean 83%) and mean 97.9% tumor coverage. Two patients experienced hearing deterioration (16.7%) in the non-NF2 group, and 3 patients (50%) in the NF2 group. No facial or trigeminal dysfunction, brain stem toxicity, or cerebellar edema occurred. Tumor regression was seen in 9 patients (43%) and stable in 12 patients (57%). 100% tumor control rate was achieved. Hypofractionated CKSRS was not only effective in tumor control but also excellent in hearing preservation for non-NF2 AN. But for NF2 patients, although the tumor control was remarkable, hearing preservation was modest as in non-NF2 patients.
KW - Acoustic neuroma
KW - CyberKnife (CK)
KW - hypofraction
KW - neurofibromatosis Type 2 (NF2)
KW - stereotactic radiosurgery
UR - http://www.scopus.com/inward/record.url?scp=52249109819&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=52249109819&partnerID=8YFLogxK
U2 - 10.1007/978-3-211-78205-7-29
DO - 10.1007/978-3-211-78205-7-29
M3 - Chapter
C2 - 18642654
SN - 9783211782040
T3 - Acta Neurochirurgica, Supplementum
SP - 169
EP - 173
BT - Acta Neurochirurgica, Supplementum
ER -