Hypoadiponectinemia

A useful marker of dyslipidemia in women with polycystic ovary syndrome

Chih Yuan Chang, Mei Jou Chen, Wei Shiung Yang, Ching Ying Yeh, Hong Nerng Ho, Shee Uan Chen, Yu Shih Yang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: Adiponectin plays a role in obesity, lipid metabolism, and anti-inflammation. Women with polycystic ovary syndrome (PCOS) are also at risk for dyslipidemia. Therefore, we investigated the association between adiponectin levels and the lipid profile including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TGs) in women with PCOS and contemplated what role adiponectin might play in dyslipidemia with PCOS. Materials and Methods: We recruited 118 young Taiwanese women with PCOS. The women enrolled were not taking any medication and those with other systemic diseases of nonovarian origin, which could have affected the hypothalamic-pituitary-ovarian axis, were excluded. The serum lipid profile, metabolic and hormonal parameters, and adiponectin were measured. The lipid profile and adiponectin were analyzed and adjusted for age, body mass index (BMI), homeostasis model assessment-insulin resistance (HOMA-IR), and sex hormone-binding globulin (SHBG). Results: In a simple linear regression, adiponectin was significantly inversely related to LDL-C and TGs, but positively related to HDL-C (all p < 0.001) after logarithmic transformation. In the multiple linear regression, adiponectin was significantly related to HDL-C (p < 0.001) independent of age, BMI, HOMA-IR, and SHBG after logarithmic transformation. Using a logistic regression, the odds ratio was 0.088 between the association of increased adiponectin and abnormal HDL-C (≤50 mg/dL). Conclusions: We demonstrated that adiponectin is an independent biomarker that is positively and evidently related to HDL-C and TGs in women with PCOS. Hypoadiponectinemia may be a useful marker of dyslipidemia in women with PCOS.

Original languageEnglish
Pages (from-to)583-590
Number of pages8
JournalTaiwanese Journal of Obstetrics and Gynecology
Volume51
Issue number4
DOIs
Publication statusPublished - Dec 1 2012

Fingerprint

Inborn Errors Metabolism
Biological Models
Sex Hormone-Binding Globulin
Polycystic Ovary Syndrome
Adiponectin
Dyslipidemias
Taiwan
LDL Cholesterol
HDL Cholesterol
Insulin Resistance
Young Adult
Linear Models
Triglycerides
Body Mass Index
Homeostasis
Biomarkers
Logistic Models
Odds Ratio
Lipids
Hypoadiponectinemia

Keywords

  • Adiponectin
  • Dyslipidemia
  • High-density lipoprotein cholesterol
  • Hypoadiponectinemia
  • Polycystic ovary syndrome
  • Triglycerides

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Hypoadiponectinemia : A useful marker of dyslipidemia in women with polycystic ovary syndrome. / Chang, Chih Yuan; Chen, Mei Jou; Yang, Wei Shiung; Yeh, Ching Ying; Ho, Hong Nerng; Chen, Shee Uan; Yang, Yu Shih.

In: Taiwanese Journal of Obstetrics and Gynecology, Vol. 51, No. 4, 01.12.2012, p. 583-590.

Research output: Contribution to journalArticle

Chang, Chih Yuan ; Chen, Mei Jou ; Yang, Wei Shiung ; Yeh, Ching Ying ; Ho, Hong Nerng ; Chen, Shee Uan ; Yang, Yu Shih. / Hypoadiponectinemia : A useful marker of dyslipidemia in women with polycystic ovary syndrome. In: Taiwanese Journal of Obstetrics and Gynecology. 2012 ; Vol. 51, No. 4. pp. 583-590.
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abstract = "Objective: Adiponectin plays a role in obesity, lipid metabolism, and anti-inflammation. Women with polycystic ovary syndrome (PCOS) are also at risk for dyslipidemia. Therefore, we investigated the association between adiponectin levels and the lipid profile including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TGs) in women with PCOS and contemplated what role adiponectin might play in dyslipidemia with PCOS. Materials and Methods: We recruited 118 young Taiwanese women with PCOS. The women enrolled were not taking any medication and those with other systemic diseases of nonovarian origin, which could have affected the hypothalamic-pituitary-ovarian axis, were excluded. The serum lipid profile, metabolic and hormonal parameters, and adiponectin were measured. The lipid profile and adiponectin were analyzed and adjusted for age, body mass index (BMI), homeostasis model assessment-insulin resistance (HOMA-IR), and sex hormone-binding globulin (SHBG). Results: In a simple linear regression, adiponectin was significantly inversely related to LDL-C and TGs, but positively related to HDL-C (all p < 0.001) after logarithmic transformation. In the multiple linear regression, adiponectin was significantly related to HDL-C (p < 0.001) independent of age, BMI, HOMA-IR, and SHBG after logarithmic transformation. Using a logistic regression, the odds ratio was 0.088 between the association of increased adiponectin and abnormal HDL-C (≤50 mg/dL). Conclusions: We demonstrated that adiponectin is an independent biomarker that is positively and evidently related to HDL-C and TGs in women with PCOS. Hypoadiponectinemia may be a useful marker of dyslipidemia in women with PCOS.",
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AU - Chang, Chih Yuan

AU - Chen, Mei Jou

AU - Yang, Wei Shiung

AU - Yeh, Ching Ying

AU - Ho, Hong Nerng

AU - Chen, Shee Uan

AU - Yang, Yu Shih

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AB - Objective: Adiponectin plays a role in obesity, lipid metabolism, and anti-inflammation. Women with polycystic ovary syndrome (PCOS) are also at risk for dyslipidemia. Therefore, we investigated the association between adiponectin levels and the lipid profile including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TGs) in women with PCOS and contemplated what role adiponectin might play in dyslipidemia with PCOS. Materials and Methods: We recruited 118 young Taiwanese women with PCOS. The women enrolled were not taking any medication and those with other systemic diseases of nonovarian origin, which could have affected the hypothalamic-pituitary-ovarian axis, were excluded. The serum lipid profile, metabolic and hormonal parameters, and adiponectin were measured. The lipid profile and adiponectin were analyzed and adjusted for age, body mass index (BMI), homeostasis model assessment-insulin resistance (HOMA-IR), and sex hormone-binding globulin (SHBG). Results: In a simple linear regression, adiponectin was significantly inversely related to LDL-C and TGs, but positively related to HDL-C (all p < 0.001) after logarithmic transformation. In the multiple linear regression, adiponectin was significantly related to HDL-C (p < 0.001) independent of age, BMI, HOMA-IR, and SHBG after logarithmic transformation. Using a logistic regression, the odds ratio was 0.088 between the association of increased adiponectin and abnormal HDL-C (≤50 mg/dL). Conclusions: We demonstrated that adiponectin is an independent biomarker that is positively and evidently related to HDL-C and TGs in women with PCOS. Hypoadiponectinemia may be a useful marker of dyslipidemia in women with PCOS.

KW - Adiponectin

KW - Dyslipidemia

KW - High-density lipoprotein cholesterol

KW - Hypoadiponectinemia

KW - Polycystic ovary syndrome

KW - Triglycerides

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