Hypervolemic hemodilution may protect the rat's striatal neurons from ischemic injury by reducing the extracellular dopamine

Chung Ching Chio, Ming Tsung Ho, Chao Ching Huang, Ying Tai Jin, Mao Tsun Lin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In vivo voltammetry (IVV) was used in rats with transient brain ischemia to measure changes in extracellular concentrations of dopamine (DA) and its metabolites in the corpus striatum. Striatal neuronal damage were also rated on a scale of 0-3 (0 = no damage; 3 = maximum cell loss). The striatal extracellular levels of DA and its metabolites increased by 12-fold during the 30 min of brain ischemia and returned to control values at 30 min after reperfusion. In another group treated with 4-5 ml of 10% human albumin intravenously infused 30 min before brain ischemia, both augmented striatal DA (and its metabolites) levels and striatal neuronal damages were reduced as compared to the ischemic control group (P <0.05, unpaired Student's t-test). These results suggest that hypervolemic hemodilution protects the striatal neurons from ischemic injury by reducing the extracellular striatal DA release in rats.

Original languageEnglish
Pages (from-to)5-8
Number of pages4
JournalNeuroscience Letters
Volume171
Issue number1-2
DOIs
Publication statusPublished - Apr 25 1994
Externally publishedYes

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Corpus Striatum
Hemodilution
Dopamine
Neurons
Wounds and Injuries
Brain Ischemia
Reperfusion
Albumins
Students
Control Groups

Keywords

  • Brain ischemia
  • Dopamine
  • Hypervolemic hemodilution
  • Rat
  • Striatum
  • Voltammetry

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hypervolemic hemodilution may protect the rat's striatal neurons from ischemic injury by reducing the extracellular dopamine. / Chio, Chung Ching; Ho, Ming Tsung; Huang, Chao Ching; Jin, Ying Tai; Lin, Mao Tsun.

In: Neuroscience Letters, Vol. 171, No. 1-2, 25.04.1994, p. 5-8.

Research output: Contribution to journalArticle

Chio, Chung Ching ; Ho, Ming Tsung ; Huang, Chao Ching ; Jin, Ying Tai ; Lin, Mao Tsun. / Hypervolemic hemodilution may protect the rat's striatal neurons from ischemic injury by reducing the extracellular dopamine. In: Neuroscience Letters. 1994 ; Vol. 171, No. 1-2. pp. 5-8.
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