Hyperventilation accelerates the rise of arterial blood concentrations of desflurane in gynecologic patients

Chih Cherng Lu, Tso Chou Lin, Che Hao Hsu, Mu Hsien Yu, Ta Liang Chen, Ruei Ming Chen, Chih Hung Ku, Shung Tai Ho

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objectives: Under a constant inspired concentration, the uptake of a volatile anesthetic into the arterial blood should mainly be governed by alveolar ventilation, according to the assumption that the patient's cardiac output remains stable during anesthesia. We investigated whether ventilation volume affects the rate of desflurane uptake by examining arterial blood concentrations. METHOD: Thirty female patients were randomly allocated into the following three groups: hyperventilation, normal ventilation and hypoventilation. Hemodynamic variables were measured using a Finometer, inspiratory and end-tidal concentrations of desflurane were measured by infrared analysis, and the desflurane concentration in the arterial blood (Ades) was analyzed by gas chromatography. Results: During the first 10 minutes after the administration of desflurane, the Ades was highest in the hyperventilation group, and this value was significantly different from those obtained for the normal and hypoventilation groups. In addition, hyperventilation significantly increased the slope of Ades-over-time during the first 5 minutes compared with patients experiencing normal ventilation and hypoventilation, but there were no differences in these slopes during the periods from 5-10, 10-20 and 20-40 minutes after the administration of desflurane. This finding indicates that there were no differences in desflurane uptake between the three groups after the first 5 minutes within desflurane administration. Conclusions: Hyperventilation accelerated the rate of the rise in Ades following desflurane administration, which was time-dependent with respect to different alveolar ventilations levels.

Original languageEnglish
Pages (from-to)1029-1034
Number of pages6
JournalClinics
Volume67
Issue number9
DOIs
Publication statusPublished - May 7 2012

Keywords

  • Arterial Blood
  • Desflurane
  • End-Tidal
  • Pharmacokinetics
  • Ventilation

ASJC Scopus subject areas

  • Medicine(all)

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