Hyperventilation accelerates rise in arterial blood concentrations of sevoflurane in gynecologic patients

Chih Cherng Lu, Tso Chou Lin, Che Hao Hsu, Mu Hsien Yu, Chih Hung Ku, Ta Liang Chen, Ruei Ming Chen, Shung Tai Ho

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Purpose: We investigated whether ventilation volumes affected arterial blood sevoflurane concentration (A sev) and its uptake into the body during general anesthesia. Methods: Thirty female patients undergoing elective gynecologic surgery were randomly allocated into three groups: hyperventilation, normal ventilation, and hypoventilation. Inspiratory (CIsev) and end-tidal (sev) sevoflurane concentrations were routinely measured by infrared analysis, and A sev were analyzed by gas chromatography for 40 min after intubation. Cardiac index and total peripheral vascular resistance were measured with a Finometer. Results: During the first 10 min after sevoflurane administration, A sev in the hyperventilation group was the highest and differed significantly from those in the normal ventilation group, followed by those in the hypoventilation group. In addition, hyperventilation significantly increased the slope of A sev over time in the first 5 min, but there were no differences in slopes in the 5-10, 10-20, and 20-40 min periods, which indicates no difference in sevoflurane bodily uptake among the three groups after 5 min. Conclusion: Hyperventilation accelerated the rate of A sev increase immediately after sevoflurane administration, which was time dependent with respect to different alveolar ventilation levels.

Original languageEnglish
Pages (from-to)35-42
Number of pages8
JournalJournal of Anesthesia
Issue number1
Publication statusPublished - Feb 2013


  • Arterial blood
  • End tidal
  • Pharmacokinetics
  • Sevoflurane
  • Ventilation

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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