Hyperthermia-mediated local drug delivery by a bubble-generating liposomal system for tumor-specific chemotherapy

Ko Jie Chen, Er Yuan Chaung, Shiaw Pyng Wey, Kun Ju Lin, Felice Cheng, Chia Chen Lin, Hao Li Liu, Hsiang Wen Tseng, Chih Peng Liu, Ming Cheng Wei, Chun Min Liu, Hsing Wen Sung

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

As is widely suspected, lysolipid dissociation from liposomes contributes to the intravenous instability of ThermoDox (lysolipid liposomes), thereby impeding its antitumor efficacy. This work evaluates the feasibility of a thermoresponsive bubble-generating liposomal system without lysolipids for tumor-specific chemotherapy. The key component in this liposomal formulation is its encapsulated ammonium bicarbonate (ABC), which is used to actively load doxorubicin (DOX) into liposomes and trigger a drug release when heated locally. Incubating ABC liposomes with whole blood results in a significantly smaller decrease in the retention of encapsulated DOX than that by lysolipid liposomes, indicating superior plasma stability. Biodistribution analysis results indicate that the ABC formulation circulates longer than its lysolipid counterpart. Following the injection of ABC liposome suspension into mice with tumors heated locally, decomposition of the ABC encapsulated in liposomes facilitates the immediate thermal activation of CO2 bubble generation, subsequently increasing the intratumoral DOX accumulation. Consequently, the antitumor efficacy of the ABC liposomes is superior to that of their lysolipid counterparts. Results of this study demonstrate that this thermoresponsive bubble-generating liposomal system is a highly promising carrier for tumor-specific chemotherapy, especially for local drug delivery mediated at hyperthermic temperatures.

Original languageEnglish
Pages (from-to)5105-5115
Number of pages11
JournalACS Nano
Volume8
Issue number5
DOIs
Publication statusPublished - May 27 2014
Externally publishedYes

Fingerprint

Chemotherapy
Ammonium bicarbonate
Liposomes
hyperthermia
chemotherapy
Drug delivery
Tumors
carbonates
delivery
drugs
bubbles
tumors
Doxorubicin
formulations
magnetohydrodynamic stability
Plasma stability
blood
mice
actuators
activation

Keywords

  • biodistribution
  • doxorubicin
  • local drug delivery
  • thermoresponsive liposome
  • triggered release

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Hyperthermia-mediated local drug delivery by a bubble-generating liposomal system for tumor-specific chemotherapy. / Chen, Ko Jie; Chaung, Er Yuan; Wey, Shiaw Pyng; Lin, Kun Ju; Cheng, Felice; Lin, Chia Chen; Liu, Hao Li; Tseng, Hsiang Wen; Liu, Chih Peng; Wei, Ming Cheng; Liu, Chun Min; Sung, Hsing Wen.

In: ACS Nano, Vol. 8, No. 5, 27.05.2014, p. 5105-5115.

Research output: Contribution to journalArticle

Chen, KJ, Chaung, EY, Wey, SP, Lin, KJ, Cheng, F, Lin, CC, Liu, HL, Tseng, HW, Liu, CP, Wei, MC, Liu, CM & Sung, HW 2014, 'Hyperthermia-mediated local drug delivery by a bubble-generating liposomal system for tumor-specific chemotherapy', ACS Nano, vol. 8, no. 5, pp. 5105-5115. https://doi.org/10.1021/nn501162x
Chen, Ko Jie ; Chaung, Er Yuan ; Wey, Shiaw Pyng ; Lin, Kun Ju ; Cheng, Felice ; Lin, Chia Chen ; Liu, Hao Li ; Tseng, Hsiang Wen ; Liu, Chih Peng ; Wei, Ming Cheng ; Liu, Chun Min ; Sung, Hsing Wen. / Hyperthermia-mediated local drug delivery by a bubble-generating liposomal system for tumor-specific chemotherapy. In: ACS Nano. 2014 ; Vol. 8, No. 5. pp. 5105-5115.
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