Hypertension of cardiac origin: A model study

J. C. Hsieh, Shih Ann Chen, Cheng Jeng Tai, John K J Li

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A modified Windkessel model was used to investigate interactions between peripheral resistance and ejection fraction in determining hypertension. Experimental aortic pressure, Pa(t), and aortic flow, Qa(t), data from mongrel dogs with an average of 23 kg were digitized and then incorporated into a three-element lumped arterial system model. By manipulating peripheral resistance (Rs), systemic capacitance (Cs), and Qa(t), the Pa(t) was studied. Results indicated that elevated Pa(t) caused by increased ejection fraction (EF) can be observed within normal or reduced peripheral impedance. Thus anti-hypertensive drugs using vasodilator could not be effective if cardiac origin of hypertension is involved.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Pages247
Number of pages1
Volume1
ISBN (Print)0780356756
Publication statusPublished - 1999
Externally publishedYes
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

Fingerprint

Vasodilator Agents
Antihypertensive Agents
Capacitance

ASJC Scopus subject areas

  • Bioengineering

Cite this

Hsieh, J. C., Chen, S. A., Tai, C. J., & Li, J. K. J. (1999). Hypertension of cardiac origin: A model study. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 1, pp. 247). IEEE.

Hypertension of cardiac origin : A model study. / Hsieh, J. C.; Chen, Shih Ann; Tai, Cheng Jeng; Li, John K J.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 1 IEEE, 1999. p. 247.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hsieh, JC, Chen, SA, Tai, CJ & Li, JKJ 1999, Hypertension of cardiac origin: A model study. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 1, IEEE, pp. 247, Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS), Atlanta, GA, USA, 10/13/99.
Hsieh JC, Chen SA, Tai CJ, Li JKJ. Hypertension of cardiac origin: A model study. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 1. IEEE. 1999. p. 247
Hsieh, J. C. ; Chen, Shih Ann ; Tai, Cheng Jeng ; Li, John K J. / Hypertension of cardiac origin : A model study. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 1 IEEE, 1999. pp. 247
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