Hyperreflexia in axonal Guillain-Barré syndrome subsequent to Campylobacter jejuni enteritis

Satoshi Kuwabara, Miho Nakata, Jia Ying Sung, Masahiro Mori, Naoko Kato, Takamichi Hattori, Michiaki Koga, Nobuhiro Yuki

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

We describe a patient with the acute motor axonal neuropathy (AMAN) form of Guillain-Barré syndrome (GBS), who showed generalized hyperreflexia. A 24-year-old man developed acute paralysis following Campylobacter jejuni enteritis. He showed exaggerated tendon reflexes with abnormal reflex spread to other segments, and was initially diagnosed as having post-infectious myelitis. Nerve conduction studies showed motor axonal degeneration (the AMAN pattern), and increased soleus H-reflex amplitudes. His serum was positive for IgG antibodies to gangliosides GM1b and GalNAc-GD1a. He was treated with plasmapheresis, resulting in rapid recovery. Hyperreflexia was still present 12 months after onset when muscle strength was completely normal. This case provides further evidence that patients with AMAN can develop increased motor neuron excitability, and possible mechanisms for the hyperreflexia are discussed.

Original languageEnglish
Pages (from-to)89-92
Number of pages4
JournalJournal of the Neurological Sciences
Volume199
Issue number1-2
DOIs
Publication statusPublished - Jul 15 2002
Externally publishedYes

Fingerprint

Abnormal Reflexes
Campylobacter jejuni
Enteritis
Myelitis
H-Reflex
Stretch Reflex
Plasmapheresis
Neural Conduction
Muscle Strength
Motor Neurons
Paralysis
Immunoglobulin G
Antibodies
Serum

Keywords

  • Acute motor axonal neuropathy
  • Anti-ganglioside antibody
  • Guillain-Barré syndrome
  • H-reflex
  • Hyperreflexia
  • Tendon reflex

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

Hyperreflexia in axonal Guillain-Barré syndrome subsequent to Campylobacter jejuni enteritis. / Kuwabara, Satoshi; Nakata, Miho; Sung, Jia Ying; Mori, Masahiro; Kato, Naoko; Hattori, Takamichi; Koga, Michiaki; Yuki, Nobuhiro.

In: Journal of the Neurological Sciences, Vol. 199, No. 1-2, 15.07.2002, p. 89-92.

Research output: Contribution to journalArticle

Kuwabara, Satoshi ; Nakata, Miho ; Sung, Jia Ying ; Mori, Masahiro ; Kato, Naoko ; Hattori, Takamichi ; Koga, Michiaki ; Yuki, Nobuhiro. / Hyperreflexia in axonal Guillain-Barré syndrome subsequent to Campylobacter jejuni enteritis. In: Journal of the Neurological Sciences. 2002 ; Vol. 199, No. 1-2. pp. 89-92.
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