Hyperparathyroidism, glucose tolerance and platelet intracellular free calcium in chronic renal failure

K. C. Lu, S. D. Shieh, S. H. Lin, S. H. Chyr, Y. F. Lin, L. K. Diang, B. L. Li, W. H H Sheu, Y. A. Ding

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Disturbance in the vitamin D/parathyroid hormone (PTH) axis may be important in the pathogenesis of glucose intolerance and insulin resistance in uraemia. To investigate possible relationships between hyperparathyroidism, intracellular free calcium ([Ca2+](i)), and glucose tolerance in chronic renal failure, we measured serum intact PTH (I-PTH) by two-site immunometric assay, platelet [Ca2+](i), using the fluorescent indicator fura-2, and plasma glucose and insulin after 14 h overnight fast and at 30, 60 and 120 min following a 75 g oral glucose load, in 18 chronic haemodialysis patients with elevated serum I-PTH. Calcitriol (1 μg) was administered parenterally at the end of each dialysis session for four weeks. This significantly decreased serum I-PTH (p2+](i), (p

Original languageEnglish
Pages (from-to)359-365
Number of pages7
JournalQuarterly Journal of Medicine
Volume87
Issue number6
Publication statusPublished - 1994
Externally publishedYes

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Hyperparathyroidism
Chronic Kidney Failure
Blood Platelets
Calcium
Parathyroid Hormone
Glucose
Serum
Glucose Intolerance
Calcitriol
Fura-2
Uremia
Vitamin D
Renal Dialysis
Insulin Resistance
Dialysis
Insulin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lu, K. C., Shieh, S. D., Lin, S. H., Chyr, S. H., Lin, Y. F., Diang, L. K., ... Ding, Y. A. (1994). Hyperparathyroidism, glucose tolerance and platelet intracellular free calcium in chronic renal failure. Quarterly Journal of Medicine, 87(6), 359-365.

Hyperparathyroidism, glucose tolerance and platelet intracellular free calcium in chronic renal failure. / Lu, K. C.; Shieh, S. D.; Lin, S. H.; Chyr, S. H.; Lin, Y. F.; Diang, L. K.; Li, B. L.; Sheu, W. H H; Ding, Y. A.

In: Quarterly Journal of Medicine, Vol. 87, No. 6, 1994, p. 359-365.

Research output: Contribution to journalArticle

Lu, KC, Shieh, SD, Lin, SH, Chyr, SH, Lin, YF, Diang, LK, Li, BL, Sheu, WHH & Ding, YA 1994, 'Hyperparathyroidism, glucose tolerance and platelet intracellular free calcium in chronic renal failure', Quarterly Journal of Medicine, vol. 87, no. 6, pp. 359-365.
Lu, K. C. ; Shieh, S. D. ; Lin, S. H. ; Chyr, S. H. ; Lin, Y. F. ; Diang, L. K. ; Li, B. L. ; Sheu, W. H H ; Ding, Y. A. / Hyperparathyroidism, glucose tolerance and platelet intracellular free calcium in chronic renal failure. In: Quarterly Journal of Medicine. 1994 ; Vol. 87, No. 6. pp. 359-365.
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