Hyperhomocysteinaemia and vascular access thrombosis among chronic hemodialysis patients in Taiwan: A retrospective study

T. C. Chen, I. K. Wang, C. H. Lee, H. W. Chang, T. T Y Chiou, C. T. Lee, J. T. Fang, M. S. Wu, K. T. Hsu, C. C. Yang, P. H. Wang, Feng Rong Chuang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Vascular access thrombosis (VAT) is an important cause of morbidity for chronic haemodialysis (HD) patients. Some risk factors for VAT have been well-defined for chronic HD patients from western countries. However, only a few such factors have been confirmed for Taiwanese patients. This study attempted to determine the association between hyperhomocysteinaemia and the incidence of VAT for chronic HD patients in Taiwan. We retrospectively enrolled a total of 196 patients into this study during 2003. The patients were separated into VAT (n = 142) and control (n = 54) group. The participants of the VAT group were identified as those having one or more VAT, and the participants of the control group were those with no VAT in the past. The mean follow-up period was 48.months. The mean serum homocysteine levels were 29.5 ±9.6 and 29.1 ± 9.5 μmol/l for the VAT (n = 142) and the control (n = 54) group, respectively. There was no significant difference in the level of homocysteine between the VAT and the control group (p = 0.70). Female chronic HD patients had significantly greater mean total homocysteine levels than male (30.89 μmol/l, 95% CI 28.84-32.94 vs. 28.06 μmol/l, 95% CI 26.32-29.82, respectively, p = 0.038). That synthetic graft was a significant risk factor for VAT was determined using multivariate logistic regression analysis. There was no association between serum total homocysteine levels and the incidence of VAT in chronic HD patients in Taiwan.

Original languageEnglish
Pages (from-to)1596-1599
Number of pages4
JournalInternational Journal of Clinical Practice
Volume60
Issue number12
DOIs
Publication statusPublished - Dec 2006
Externally publishedYes

Fingerprint

Hyperhomocysteinemia
Taiwan
Blood Vessels
Renal Dialysis
Thrombosis
Retrospective Studies
Homocysteine
Control Groups
Incidence
Serum
Logistic Models
Regression Analysis

Keywords

  • End-stage renal disease
  • Haemodialysis
  • Hyperhomocysteinaemia
  • Vascular access thrombosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hyperhomocysteinaemia and vascular access thrombosis among chronic hemodialysis patients in Taiwan : A retrospective study. / Chen, T. C.; Wang, I. K.; Lee, C. H.; Chang, H. W.; Chiou, T. T Y; Lee, C. T.; Fang, J. T.; Wu, M. S.; Hsu, K. T.; Yang, C. C.; Wang, P. H.; Chuang, Feng Rong.

In: International Journal of Clinical Practice, Vol. 60, No. 12, 12.2006, p. 1596-1599.

Research output: Contribution to journalArticle

Chen, TC, Wang, IK, Lee, CH, Chang, HW, Chiou, TTY, Lee, CT, Fang, JT, Wu, MS, Hsu, KT, Yang, CC, Wang, PH & Chuang, FR 2006, 'Hyperhomocysteinaemia and vascular access thrombosis among chronic hemodialysis patients in Taiwan: A retrospective study', International Journal of Clinical Practice, vol. 60, no. 12, pp. 1596-1599. https://doi.org/10.1111/j.1742-1241.2006.00848.x
Chen, T. C. ; Wang, I. K. ; Lee, C. H. ; Chang, H. W. ; Chiou, T. T Y ; Lee, C. T. ; Fang, J. T. ; Wu, M. S. ; Hsu, K. T. ; Yang, C. C. ; Wang, P. H. ; Chuang, Feng Rong. / Hyperhomocysteinaemia and vascular access thrombosis among chronic hemodialysis patients in Taiwan : A retrospective study. In: International Journal of Clinical Practice. 2006 ; Vol. 60, No. 12. pp. 1596-1599.
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abstract = "Vascular access thrombosis (VAT) is an important cause of morbidity for chronic haemodialysis (HD) patients. Some risk factors for VAT have been well-defined for chronic HD patients from western countries. However, only a few such factors have been confirmed for Taiwanese patients. This study attempted to determine the association between hyperhomocysteinaemia and the incidence of VAT for chronic HD patients in Taiwan. We retrospectively enrolled a total of 196 patients into this study during 2003. The patients were separated into VAT (n = 142) and control (n = 54) group. The participants of the VAT group were identified as those having one or more VAT, and the participants of the control group were those with no VAT in the past. The mean follow-up period was 48.months. The mean serum homocysteine levels were 29.5 ±9.6 and 29.1 ± 9.5 μmol/l for the VAT (n = 142) and the control (n = 54) group, respectively. There was no significant difference in the level of homocysteine between the VAT and the control group (p = 0.70). Female chronic HD patients had significantly greater mean total homocysteine levels than male (30.89 μmol/l, 95{\%} CI 28.84-32.94 vs. 28.06 μmol/l, 95{\%} CI 26.32-29.82, respectively, p = 0.038). That synthetic graft was a significant risk factor for VAT was determined using multivariate logistic regression analysis. There was no association between serum total homocysteine levels and the incidence of VAT in chronic HD patients in Taiwan.",
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T2 - A retrospective study

AU - Chen, T. C.

AU - Wang, I. K.

AU - Lee, C. H.

AU - Chang, H. W.

AU - Chiou, T. T Y

AU - Lee, C. T.

AU - Fang, J. T.

AU - Wu, M. S.

AU - Hsu, K. T.

AU - Yang, C. C.

AU - Wang, P. H.

AU - Chuang, Feng Rong

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N2 - Vascular access thrombosis (VAT) is an important cause of morbidity for chronic haemodialysis (HD) patients. Some risk factors for VAT have been well-defined for chronic HD patients from western countries. However, only a few such factors have been confirmed for Taiwanese patients. This study attempted to determine the association between hyperhomocysteinaemia and the incidence of VAT for chronic HD patients in Taiwan. We retrospectively enrolled a total of 196 patients into this study during 2003. The patients were separated into VAT (n = 142) and control (n = 54) group. The participants of the VAT group were identified as those having one or more VAT, and the participants of the control group were those with no VAT in the past. The mean follow-up period was 48.months. The mean serum homocysteine levels were 29.5 ±9.6 and 29.1 ± 9.5 μmol/l for the VAT (n = 142) and the control (n = 54) group, respectively. There was no significant difference in the level of homocysteine between the VAT and the control group (p = 0.70). Female chronic HD patients had significantly greater mean total homocysteine levels than male (30.89 μmol/l, 95% CI 28.84-32.94 vs. 28.06 μmol/l, 95% CI 26.32-29.82, respectively, p = 0.038). That synthetic graft was a significant risk factor for VAT was determined using multivariate logistic regression analysis. There was no association between serum total homocysteine levels and the incidence of VAT in chronic HD patients in Taiwan.

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KW - End-stage renal disease

KW - Haemodialysis

KW - Hyperhomocysteinaemia

KW - Vascular access thrombosis

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