Hyperhomocysteinaemia and vascular access thrombosis among chronic hemodialysis patients in Taiwan: A retrospective study

T. C. Chen, I. K. Wang, C. H. Lee, H. W. Chang, T. T Y Chiou, C. T. Lee, J. T. Fang, M. S. Wu, K. T. Hsu, C. C. Yang, P. H. Wang, Feng Rong Chuang

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Abstract

Vascular access thrombosis (VAT) is an important cause of morbidity for chronic haemodialysis (HD) patients. Some risk factors for VAT have been well-defined for chronic HD patients from western countries. However, only a few such factors have been confirmed for Taiwanese patients. This study attempted to determine the association between hyperhomocysteinaemia and the incidence of VAT for chronic HD patients in Taiwan. We retrospectively enrolled a total of 196 patients into this study during 2003. The patients were separated into VAT (n = 142) and control (n = 54) group. The participants of the VAT group were identified as those having one or more VAT, and the participants of the control group were those with no VAT in the past. The mean follow-up period was 48.months. The mean serum homocysteine levels were 29.5 ±9.6 and 29.1 ± 9.5 μmol/l for the VAT (n = 142) and the control (n = 54) group, respectively. There was no significant difference in the level of homocysteine between the VAT and the control group (p = 0.70). Female chronic HD patients had significantly greater mean total homocysteine levels than male (30.89 μmol/l, 95% CI 28.84-32.94 vs. 28.06 μmol/l, 95% CI 26.32-29.82, respectively, p = 0.038). That synthetic graft was a significant risk factor for VAT was determined using multivariate logistic regression analysis. There was no association between serum total homocysteine levels and the incidence of VAT in chronic HD patients in Taiwan.

Original languageEnglish
Pages (from-to)1596-1599
Number of pages4
JournalInternational Journal of Clinical Practice
Volume60
Issue number12
DOIs
Publication statusPublished - Dec 2006
Externally publishedYes

Keywords

  • End-stage renal disease
  • Haemodialysis
  • Hyperhomocysteinaemia
  • Vascular access thrombosis

ASJC Scopus subject areas

  • Medicine(all)

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    Chen, T. C., Wang, I. K., Lee, C. H., Chang, H. W., Chiou, T. T. Y., Lee, C. T., Fang, J. T., Wu, M. S., Hsu, K. T., Yang, C. C., Wang, P. H., & Chuang, F. R. (2006). Hyperhomocysteinaemia and vascular access thrombosis among chronic hemodialysis patients in Taiwan: A retrospective study. International Journal of Clinical Practice, 60(12), 1596-1599. https://doi.org/10.1111/j.1742-1241.2006.00848.x