Hyperglycemia-Induced Cardiac Damage Is Alleviated by Heat-Inactivated Lactobacillus reuteri GMNL-263 via Activation of the IGF1R Survival Pathway

Ker Ping Koay, Bruce Chi Kang Tsai, Chia Hua Kuo, Wei Wen Kuo, Hsiang Ning Luk, Cecilia Hsuan Day, Ray Jade Chen, Michael Yu Chih Chen, V. Vijaya Padma, Chih Yang Huang

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Abstract: Diabetes-induced cardiomyocyte apoptosis is one of the major causes of mortality in patients with diabetes. Numerous studies have indicated the beneficial effects of Lactobacillus reuteri GMNL-263. However, the protective effect of Lactobacillus reuteri GMNL-263 in cardiac damage associated with diabetes remains poorly understood. In this study, we aimed to investigate the protective effect of Lactobacillus reuteri GMNL-263 on cardiomyocytes in diabetic rats. Five-week-old male Wistar rats were categorized into normal control group, diabetes group (55 mg/kgw STZ-induced diabetes via intraperitoneal injection), and diabetic animals treated with Lactobacillus reuteri GMNL-263 (109 CFU/rat/day, oral administration for 4 weeks). The results were presented that oral administration of a high dose of Lactobacillus reuteri GMNL-263 in diabetic rats activated IGF1R cell survival pathways to decrease the Fas-dependent and mitochondrial-dependent apoptotic pathways induced by hyperglycemia. We found that GMNL-263 significantly attenuated cell apoptosis via the IGF1R survival pathway in diabetic rats. The findings of this study suggest that GMNL-263 treatment maybe an effective therapeutic approach for the prevention of cardiac apoptosis in patients with diabetes. Graphical abstract: [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)1044-1053
Number of pages10
JournalProbiotics and Antimicrobial Proteins
Volume13
Issue number4
DOIs
Publication statusPublished - Aug 2021

Keywords

  • Diabetes
  • GMNL-263
  • Heart
  • Hyperglycemia
  • IGF1R

ASJC Scopus subject areas

  • Microbiology
  • Molecular Medicine
  • Molecular Biology

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