Hypercholesterolemia is correlated with an increased risk of idiopathic sudden sensorineural hearing loss: A historical prospective cohort study

Shih Lun Chang, Chen Chou Hsieh, Kuo Shu Tseng, Shih Feng Weng, Yong-Song Lin

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

OBJECTIVE:: Despite the many studies on the associated risk of cardiovascular and cerebrovascular events in patients with hypercholesterolemia (HCh), an association between HCh and the development of idiopathic sudden sensorineural hearing loss (ISSNHL) has been examined in only a few case-control studies. We tested the hypothesis that HCh is a risk factor for developing ISSNHL. DESIGN:: Using the Taiwan Longitudinal Health Insurance Database, we conducted a historical prospective cohort study to compare patients diagnosed with HCh from January 1, 2001, through to December 31, 2006 (N = 73,957) with age-matched controls (N = 73,957). We followed each patient until the end of 2009 and evaluated the incidence of ISSNHL for a minimum of 3 years after the initial HCh diagnosis. RESULTS:: The incidence of ISSNHL was 1.62 times higher in the HCh cohort than in the non-HCh cohort (10.67 versus 6.61 per 10,000 person-years). Using Cox proportional hazard regressions, the adjusted hazard ratio was 1.60 (95% confidence interval [CI] = 1.39-1.85). An increased risk of developing ISSNHL, with adjusted hazard ratios of 1.48 (95% CI = 1.08-2.04) and 1.69 (95% CI = 1.18-2.43), was observed in HCh patients with newly diagnosed comorbidities of stroke or stroke combined with coronary artery diseases, which are both expected to reflect the severity of HCh. CONCLUSIONS:: A diagnosis of HCh may indicate an independent risk for ISSNHL. This finding suggests that an underlying vascular mechanism contributes to the development of ISSNHL. We suggest that physicians counsel patients with HCh to seek medical attention if they have hearing impairments, because they may also have an increased risk of developing ISSNHL.

Original languageEnglish
Pages (from-to)256-261
Number of pages6
JournalEar and Hearing
Volume35
Issue number2
DOIs
Publication statusPublished - Mar 2014

Fingerprint

Sudden Hearing Loss
Sensorineural Hearing Loss
Hypercholesterolemia
Cohort Studies
Prospective Studies
Confidence Intervals
Stroke
Incidence
Health Insurance
Taiwan
Hearing Loss
Blood Vessels
Case-Control Studies
Comorbidity
Coronary Artery Disease
Databases
Physicians

Keywords

  • Coronary arterial disease
  • Diabetes
  • Hypercholesterolemia
  • Hypertension
  • Idiopathic sudden sensorineural hearing loss

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Speech and Hearing

Cite this

Hypercholesterolemia is correlated with an increased risk of idiopathic sudden sensorineural hearing loss : A historical prospective cohort study. / Chang, Shih Lun; Hsieh, Chen Chou; Tseng, Kuo Shu; Weng, Shih Feng; Lin, Yong-Song.

In: Ear and Hearing, Vol. 35, No. 2, 03.2014, p. 256-261.

Research output: Contribution to journalReview article

Chang, Shih Lun ; Hsieh, Chen Chou ; Tseng, Kuo Shu ; Weng, Shih Feng ; Lin, Yong-Song. / Hypercholesterolemia is correlated with an increased risk of idiopathic sudden sensorineural hearing loss : A historical prospective cohort study. In: Ear and Hearing. 2014 ; Vol. 35, No. 2. pp. 256-261.
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abstract = "OBJECTIVE:: Despite the many studies on the associated risk of cardiovascular and cerebrovascular events in patients with hypercholesterolemia (HCh), an association between HCh and the development of idiopathic sudden sensorineural hearing loss (ISSNHL) has been examined in only a few case-control studies. We tested the hypothesis that HCh is a risk factor for developing ISSNHL. DESIGN:: Using the Taiwan Longitudinal Health Insurance Database, we conducted a historical prospective cohort study to compare patients diagnosed with HCh from January 1, 2001, through to December 31, 2006 (N = 73,957) with age-matched controls (N = 73,957). We followed each patient until the end of 2009 and evaluated the incidence of ISSNHL for a minimum of 3 years after the initial HCh diagnosis. RESULTS:: The incidence of ISSNHL was 1.62 times higher in the HCh cohort than in the non-HCh cohort (10.67 versus 6.61 per 10,000 person-years). Using Cox proportional hazard regressions, the adjusted hazard ratio was 1.60 (95{\%} confidence interval [CI] = 1.39-1.85). An increased risk of developing ISSNHL, with adjusted hazard ratios of 1.48 (95{\%} CI = 1.08-2.04) and 1.69 (95{\%} CI = 1.18-2.43), was observed in HCh patients with newly diagnosed comorbidities of stroke or stroke combined with coronary artery diseases, which are both expected to reflect the severity of HCh. CONCLUSIONS:: A diagnosis of HCh may indicate an independent risk for ISSNHL. This finding suggests that an underlying vascular mechanism contributes to the development of ISSNHL. We suggest that physicians counsel patients with HCh to seek medical attention if they have hearing impairments, because they may also have an increased risk of developing ISSNHL.",
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T1 - Hypercholesterolemia is correlated with an increased risk of idiopathic sudden sensorineural hearing loss

T2 - A historical prospective cohort study

AU - Chang, Shih Lun

AU - Hsieh, Chen Chou

AU - Tseng, Kuo Shu

AU - Weng, Shih Feng

AU - Lin, Yong-Song

PY - 2014/3

Y1 - 2014/3

N2 - OBJECTIVE:: Despite the many studies on the associated risk of cardiovascular and cerebrovascular events in patients with hypercholesterolemia (HCh), an association between HCh and the development of idiopathic sudden sensorineural hearing loss (ISSNHL) has been examined in only a few case-control studies. We tested the hypothesis that HCh is a risk factor for developing ISSNHL. DESIGN:: Using the Taiwan Longitudinal Health Insurance Database, we conducted a historical prospective cohort study to compare patients diagnosed with HCh from January 1, 2001, through to December 31, 2006 (N = 73,957) with age-matched controls (N = 73,957). We followed each patient until the end of 2009 and evaluated the incidence of ISSNHL for a minimum of 3 years after the initial HCh diagnosis. RESULTS:: The incidence of ISSNHL was 1.62 times higher in the HCh cohort than in the non-HCh cohort (10.67 versus 6.61 per 10,000 person-years). Using Cox proportional hazard regressions, the adjusted hazard ratio was 1.60 (95% confidence interval [CI] = 1.39-1.85). An increased risk of developing ISSNHL, with adjusted hazard ratios of 1.48 (95% CI = 1.08-2.04) and 1.69 (95% CI = 1.18-2.43), was observed in HCh patients with newly diagnosed comorbidities of stroke or stroke combined with coronary artery diseases, which are both expected to reflect the severity of HCh. CONCLUSIONS:: A diagnosis of HCh may indicate an independent risk for ISSNHL. This finding suggests that an underlying vascular mechanism contributes to the development of ISSNHL. We suggest that physicians counsel patients with HCh to seek medical attention if they have hearing impairments, because they may also have an increased risk of developing ISSNHL.

AB - OBJECTIVE:: Despite the many studies on the associated risk of cardiovascular and cerebrovascular events in patients with hypercholesterolemia (HCh), an association between HCh and the development of idiopathic sudden sensorineural hearing loss (ISSNHL) has been examined in only a few case-control studies. We tested the hypothesis that HCh is a risk factor for developing ISSNHL. DESIGN:: Using the Taiwan Longitudinal Health Insurance Database, we conducted a historical prospective cohort study to compare patients diagnosed with HCh from January 1, 2001, through to December 31, 2006 (N = 73,957) with age-matched controls (N = 73,957). We followed each patient until the end of 2009 and evaluated the incidence of ISSNHL for a minimum of 3 years after the initial HCh diagnosis. RESULTS:: The incidence of ISSNHL was 1.62 times higher in the HCh cohort than in the non-HCh cohort (10.67 versus 6.61 per 10,000 person-years). Using Cox proportional hazard regressions, the adjusted hazard ratio was 1.60 (95% confidence interval [CI] = 1.39-1.85). An increased risk of developing ISSNHL, with adjusted hazard ratios of 1.48 (95% CI = 1.08-2.04) and 1.69 (95% CI = 1.18-2.43), was observed in HCh patients with newly diagnosed comorbidities of stroke or stroke combined with coronary artery diseases, which are both expected to reflect the severity of HCh. CONCLUSIONS:: A diagnosis of HCh may indicate an independent risk for ISSNHL. This finding suggests that an underlying vascular mechanism contributes to the development of ISSNHL. We suggest that physicians counsel patients with HCh to seek medical attention if they have hearing impairments, because they may also have an increased risk of developing ISSNHL.

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KW - Diabetes

KW - Hypercholesterolemia

KW - Hypertension

KW - Idiopathic sudden sensorineural hearing loss

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