Hypercalcemia in prostate cancer with positive neuron-specific enolase stain

Ching Heng Wu, Yii Jenq Lan, Cheng Hsu Wang, Mai Szu Wu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Hypercalcemia is a common complication of malignant diseases with or without bone metastasis. Hypercalcemia in prostate cancer is rarely seen. The exact mechanism of prostate cancer-related hypercalcemia is still uncertain. Secretion of parathyroid hormone-related peptides (PTH-rP) is thought to be one of the possible mechanisms. We reported a rare case of prostate cancer with hypercalcemia (13 mg/dL). Bone marrow biopsy showed metastatic adenocarcinoma. The cells were also positive for neuron-specific enolase, which is the specific marker for neuroendocrine cell. The finding suggested that the prostate cancer cell derived from the neuroendocrine cell, which might synthesize PTH-rP and be responsible for the observed hypercalcemia.

Original languageEnglish
Pages (from-to)325-327
Number of pages3
JournalRenal Failure
Volume26
Issue number3
DOIs
Publication statusPublished - 2004
Externally publishedYes

Fingerprint

Phosphopyruvate Hydratase
Hypercalcemia
Prostatic Neoplasms
Coloring Agents
Parathyroid Hormone-Related Protein
Neuroendocrine Cells
Adenocarcinoma
Bone Marrow
Neoplasm Metastasis
Biopsy
Bone and Bones

Keywords

  • Hypercalcemia
  • Neuron-specific enolase
  • Parathyroid hormone-related peptide
  • Prostate cancer

ASJC Scopus subject areas

  • Nephrology

Cite this

Hypercalcemia in prostate cancer with positive neuron-specific enolase stain. / Wu, Ching Heng; Lan, Yii Jenq; Wang, Cheng Hsu; Wu, Mai Szu.

In: Renal Failure, Vol. 26, No. 3, 2004, p. 325-327.

Research output: Contribution to journalArticle

Wu, Ching Heng ; Lan, Yii Jenq ; Wang, Cheng Hsu ; Wu, Mai Szu. / Hypercalcemia in prostate cancer with positive neuron-specific enolase stain. In: Renal Failure. 2004 ; Vol. 26, No. 3. pp. 325-327.
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