Hypercalcemia and Lytic Bone Lesions in a Patient with B-Cell Non-Hodgkin's Lymphoma

Renee H. Jacobs, Richard A. Larson, Michelle Lebeau, Larry F. Kluskens, James W. Vardiman, Janet D. Rowley, Harvey M. Golomb, Paul A. Bunn, Geraldine P. Schechter, Jacqueline Whang-Peng, Elaine Jaffe, Robert Young, William Blattner, Samuel Broder, Robert C. Gallo

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To the Editor: Bunn et al. comment that the presence of retrovirus-associated T-cell lymphomas should be strongly suspected on clinical grounds in patients who present with hypercalcemia and metabolic bone abnormalities (Aug. 4 issue).1 In August 1983, we evaluated a 29-year-old white man with painful lytic bone lesions, refractory hypercalcemia (16.0 mg per deciliter), and leukocytosis (53,000 per microliter); 42 percent of the circulating cells resembled poorly differentiated lymphoma cells with marked nuclear clefting and folding. Eleven years earlier the patient had received total-nodal irradiation for Hodgkin's disease (nodular sclerosing), followed two years later by MOPP (mechlorethamine, vincristine, procarbazine,.

Original languageEnglish
Pages (from-to)263-264
Number of pages2
JournalNew England Journal of Medicine
Issue number4
Publication statusPublished - Jan 26 1984
Externally publishedYes


ASJC Scopus subject areas

  • Medicine(all)

Cite this

Jacobs, R. H., Larson, R. A., Lebeau, M., Kluskens, L. F., Vardiman, J. W., Rowley, J. D., Golomb, H. M., Bunn, P. A., Schechter, G. P., Whang-Peng, J., Jaffe, E., Young, R., Blattner, W., Broder, S., & Gallo, R. C. (1984). Hypercalcemia and Lytic Bone Lesions in a Patient with B-Cell Non-Hodgkin's Lymphoma. New England Journal of Medicine, 310(4), 263-264. https://doi.org/10.1056/NEJM198401263100419