Hypercalcemia and Lytic Bone Lesions in a Patient with B-Cell Non-Hodgkin's Lymphoma

Renee H. Jacobs, Richard A. Larson, Michelle Lebeau, Larry F. Kluskens, James W. Vardiman, Janet D. Rowley, Harvey M. Golomb, Paul A. Bunn, Geraldine P. Schechter, Jacqueline Whang-Peng, Elaine Jaffe, Robert Young, William Blattner, Samuel Broder, Robert C. Gallo

Research output: Contribution to journalLetter

6 Citations (Scopus)

Abstract

To the Editor: Bunn et al. comment that the presence of retrovirus-associated T-cell lymphomas should be strongly suspected on clinical grounds in patients who present with hypercalcemia and metabolic bone abnormalities (Aug. 4 issue).1 In August 1983, we evaluated a 29-year-old white man with painful lytic bone lesions, refractory hypercalcemia (16.0 mg per deciliter), and leukocytosis (53,000 per microliter); 42 percent of the circulating cells resembled poorly differentiated lymphoma cells with marked nuclear clefting and folding. Eleven years earlier the patient had received total-nodal irradiation for Hodgkin's disease (nodular sclerosing), followed two years later by MOPP (mechlorethamine, vincristine, procarbazine,.

Original languageEnglish
Pages (from-to)263-264
Number of pages2
JournalNew England Journal of Medicine
Volume310
Issue number4
DOIs
Publication statusPublished - Jan 26 1984
Externally publishedYes

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Hypercalcemia
B-Cell Lymphoma
Non-Hodgkin's Lymphoma
Procarbazine
Bone and Bones
Mechlorethamine
T-Cell Lymphoma
Leukocytosis
Vincristine
Retroviridae
Hodgkin Disease
Lymphoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Jacobs, R. H., Larson, R. A., Lebeau, M., Kluskens, L. F., Vardiman, J. W., Rowley, J. D., ... Gallo, R. C. (1984). Hypercalcemia and Lytic Bone Lesions in a Patient with B-Cell Non-Hodgkin's Lymphoma. New England Journal of Medicine, 310(4), 263-264. https://doi.org/10.1056/NEJM198401263100419

Hypercalcemia and Lytic Bone Lesions in a Patient with B-Cell Non-Hodgkin's Lymphoma. / Jacobs, Renee H.; Larson, Richard A.; Lebeau, Michelle; Kluskens, Larry F.; Vardiman, James W.; Rowley, Janet D.; Golomb, Harvey M.; Bunn, Paul A.; Schechter, Geraldine P.; Whang-Peng, Jacqueline; Jaffe, Elaine; Young, Robert; Blattner, William; Broder, Samuel; Gallo, Robert C.

In: New England Journal of Medicine, Vol. 310, No. 4, 26.01.1984, p. 263-264.

Research output: Contribution to journalLetter

Jacobs, RH, Larson, RA, Lebeau, M, Kluskens, LF, Vardiman, JW, Rowley, JD, Golomb, HM, Bunn, PA, Schechter, GP, Whang-Peng, J, Jaffe, E, Young, R, Blattner, W, Broder, S & Gallo, RC 1984, 'Hypercalcemia and Lytic Bone Lesions in a Patient with B-Cell Non-Hodgkin's Lymphoma', New England Journal of Medicine, vol. 310, no. 4, pp. 263-264. https://doi.org/10.1056/NEJM198401263100419
Jacobs RH, Larson RA, Lebeau M, Kluskens LF, Vardiman JW, Rowley JD et al. Hypercalcemia and Lytic Bone Lesions in a Patient with B-Cell Non-Hodgkin's Lymphoma. New England Journal of Medicine. 1984 Jan 26;310(4):263-264. https://doi.org/10.1056/NEJM198401263100419
Jacobs, Renee H. ; Larson, Richard A. ; Lebeau, Michelle ; Kluskens, Larry F. ; Vardiman, James W. ; Rowley, Janet D. ; Golomb, Harvey M. ; Bunn, Paul A. ; Schechter, Geraldine P. ; Whang-Peng, Jacqueline ; Jaffe, Elaine ; Young, Robert ; Blattner, William ; Broder, Samuel ; Gallo, Robert C. / Hypercalcemia and Lytic Bone Lesions in a Patient with B-Cell Non-Hodgkin's Lymphoma. In: New England Journal of Medicine. 1984 ; Vol. 310, No. 4. pp. 263-264.
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abstract = "To the Editor: Bunn et al. comment that the presence of retrovirus-associated T-cell lymphomas should be strongly suspected on clinical grounds in patients who present with hypercalcemia and metabolic bone abnormalities (Aug. 4 issue).1 In August 1983, we evaluated a 29-year-old white man with painful lytic bone lesions, refractory hypercalcemia (16.0 mg per deciliter), and leukocytosis (53,000 per microliter); 42 percent of the circulating cells resembled poorly differentiated lymphoma cells with marked nuclear clefting and folding. Eleven years earlier the patient had received total-nodal irradiation for Hodgkin's disease (nodular sclerosing), followed two years later by MOPP (mechlorethamine, vincristine, procarbazine,.",
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AU - Jacobs, Renee H.

AU - Larson, Richard A.

AU - Lebeau, Michelle

AU - Kluskens, Larry F.

AU - Vardiman, James W.

AU - Rowley, Janet D.

AU - Golomb, Harvey M.

AU - Bunn, Paul A.

AU - Schechter, Geraldine P.

AU - Whang-Peng, Jacqueline

AU - Jaffe, Elaine

AU - Young, Robert

AU - Blattner, William

AU - Broder, Samuel

AU - Gallo, Robert C.

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AB - To the Editor: Bunn et al. comment that the presence of retrovirus-associated T-cell lymphomas should be strongly suspected on clinical grounds in patients who present with hypercalcemia and metabolic bone abnormalities (Aug. 4 issue).1 In August 1983, we evaluated a 29-year-old white man with painful lytic bone lesions, refractory hypercalcemia (16.0 mg per deciliter), and leukocytosis (53,000 per microliter); 42 percent of the circulating cells resembled poorly differentiated lymphoma cells with marked nuclear clefting and folding. Eleven years earlier the patient had received total-nodal irradiation for Hodgkin's disease (nodular sclerosing), followed two years later by MOPP (mechlorethamine, vincristine, procarbazine,.

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