Hyperbaric oxygen therapy for treatment of postischemic stroke in adult rats

C. F. Chang, K. C. Niu, B. J. Hoffer, Y. Wang, C. V. Borlongan

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

The efficacy of hyperbaric oxygen (HBO) therapy for treatment of stroke remains to be validated in the laboratory. We report here that adult rats subjected to occlusion of the middle cerebral artery and subsequently exposed to HBO (3 atm, 2 x 90 min at a 24-h intervals; animals terminated shortly after the second treatment) or hyperbaric pressure (HBP; 3 atm, 2 x 90 min at a 24-h interval; animals terminated shortly after the second treatment) immediately after the ischemia or after a 60-min delay generally displayed recovery from motor deficits at 2.5 and 24 h of reperfusion, as well as a reduction in cerebral infarction at 24 h of reperfusion compared to ischemic animals subjected to normal atmospheric pressure. While both HBO and HBP treatments promoted beneficial effects, HBO produced more consistent protection than HBP. Treatment with HBO immediately or 60 min after reperfusion equally produced significant attenuations of cerebral infarction and motor deficits. In contrast, protective effects of HBP treatment against ischemia were noted only when administered immediately after ischemia, which resulted in a significantly reduced infarction volume, but only produced a trend toward decreased behavioral deficits. The present results demonstrate that HBO and, to some extent, HBP reduced ischemic brain damage and behavioral dysfunctions.

Original languageEnglish
Pages (from-to)298-306
Number of pages9
JournalExperimental Neurology
Volume166
Issue number2
DOIs
Publication statusPublished - 2000
Externally publishedYes

Fingerprint

Hyperbaric Oxygenation
Stroke
Oxygen
Reperfusion
Ischemia
Cerebral Infarction
Therapeutics
Atmospheric Pressure
Middle Cerebral Artery Infarction
Infarction
Pressure
Brain

Keywords

  • Arterial pressure
  • Cerebral ischemia
  • Hyperbaric pressure
  • Hyperoxygenation
  • Motor asymmetry
  • Plasma pH
  • Reperfusion

ASJC Scopus subject areas

  • Neurology
  • Neuroscience(all)

Cite this

Chang, C. F., Niu, K. C., Hoffer, B. J., Wang, Y., & Borlongan, C. V. (2000). Hyperbaric oxygen therapy for treatment of postischemic stroke in adult rats. Experimental Neurology, 166(2), 298-306. https://doi.org/10.1006/exnr.2000.7506

Hyperbaric oxygen therapy for treatment of postischemic stroke in adult rats. / Chang, C. F.; Niu, K. C.; Hoffer, B. J.; Wang, Y.; Borlongan, C. V.

In: Experimental Neurology, Vol. 166, No. 2, 2000, p. 298-306.

Research output: Contribution to journalArticle

Chang, CF, Niu, KC, Hoffer, BJ, Wang, Y & Borlongan, CV 2000, 'Hyperbaric oxygen therapy for treatment of postischemic stroke in adult rats', Experimental Neurology, vol. 166, no. 2, pp. 298-306. https://doi.org/10.1006/exnr.2000.7506
Chang, C. F. ; Niu, K. C. ; Hoffer, B. J. ; Wang, Y. ; Borlongan, C. V. / Hyperbaric oxygen therapy for treatment of postischemic stroke in adult rats. In: Experimental Neurology. 2000 ; Vol. 166, No. 2. pp. 298-306.
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