Hyperamylasemia following cardiopulmonary bypass.

H. Chang, Y. T. Chung, G. J. Wu, F. Y. Hwang, K. T. Chen, W. L. Peng, C. R. Hung

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In order to study the occurrence of postbypass hyperamylasemia, 75 patients undergoing cardiopulmonary bypass (CPB) were studied from March 1989 to January 1990. There were 49 males and 26 females. Among them, 27 had congenital heart disease, 30 had valvular disease, and 18 had coronary artery disease. There were 27 patients with at least one elevated serum amylase sample after operation. Thus, the overall incidence of hyperamylasemia was 36%. As compared with the preoperative data (1.3%), there was a statistically significant difference in the occurrence of hyperamylasemia (p less than 0.05). Three patients had overt clinical pancreatitis postoperatively. There was no positive correlation between the serum amylase level and the occurrence of pancreatitis (p greater than 0.05). Forty-two cases had a significant elevation of the amylase creatinine clearance ratio (ACCR) after CPB. However, there was no significant difference between the groups with pulsatile and nonpulsatile CPB (p greater than 0.05). Three patients (4%) died in our series. The causes of death were heart failure in two and fulminant pancreatitis associated with low cardiac output in one. Although our experience in dealing with pancreatitis improved survival, mortality was still high (33.3%) in our series. Nevertheless, there was no apparent correlation between mortality and postbypass hyperamylasemia (p greater than 0.05). Logistic regression analysis was used to analyze the risk factors of the occurrence of hyperamylasemia, and the analysis revealed that patients with coronary artery disease were susceptible to postbypass hyperamylasemia. Our studies indicate that the use of total serum amylase or ACCR to monitor for the occurrence of pancreatitis in postbypass patients is inadequate.(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageEnglish
Pages (from-to)34-40
Number of pages7
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Volume91
Issue number1
Publication statusPublished - Jan 1992
Externally publishedYes

Fingerprint

Hyperamylasemia
Cardiopulmonary Bypass
Amylases
Pancreatitis
Coronary Artery Disease
Creatinine
Serum
Low Cardiac Output
Mortality
Cause of Death
Heart Diseases
Heart Failure
Logistic Models
Regression Analysis
Survival
Incidence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Chang, H., Chung, Y. T., Wu, G. J., Hwang, F. Y., Chen, K. T., Peng, W. L., & Hung, C. R. (1992). Hyperamylasemia following cardiopulmonary bypass. Journal of the Formosan Medical Association = Taiwan yi zhi, 91(1), 34-40.

Hyperamylasemia following cardiopulmonary bypass. / Chang, H.; Chung, Y. T.; Wu, G. J.; Hwang, F. Y.; Chen, K. T.; Peng, W. L.; Hung, C. R.

In: Journal of the Formosan Medical Association = Taiwan yi zhi, Vol. 91, No. 1, 01.1992, p. 34-40.

Research output: Contribution to journalArticle

Chang, H, Chung, YT, Wu, GJ, Hwang, FY, Chen, KT, Peng, WL & Hung, CR 1992, 'Hyperamylasemia following cardiopulmonary bypass.', Journal of the Formosan Medical Association = Taiwan yi zhi, vol. 91, no. 1, pp. 34-40.
Chang H, Chung YT, Wu GJ, Hwang FY, Chen KT, Peng WL et al. Hyperamylasemia following cardiopulmonary bypass. Journal of the Formosan Medical Association = Taiwan yi zhi. 1992 Jan;91(1):34-40.
Chang, H. ; Chung, Y. T. ; Wu, G. J. ; Hwang, F. Y. ; Chen, K. T. ; Peng, W. L. ; Hung, C. R. / Hyperamylasemia following cardiopulmonary bypass. In: Journal of the Formosan Medical Association = Taiwan yi zhi. 1992 ; Vol. 91, No. 1. pp. 34-40.
@article{aba01b4a33de45eeac543134846dd25f,
title = "Hyperamylasemia following cardiopulmonary bypass.",
abstract = "In order to study the occurrence of postbypass hyperamylasemia, 75 patients undergoing cardiopulmonary bypass (CPB) were studied from March 1989 to January 1990. There were 49 males and 26 females. Among them, 27 had congenital heart disease, 30 had valvular disease, and 18 had coronary artery disease. There were 27 patients with at least one elevated serum amylase sample after operation. Thus, the overall incidence of hyperamylasemia was 36{\%}. As compared with the preoperative data (1.3{\%}), there was a statistically significant difference in the occurrence of hyperamylasemia (p less than 0.05). Three patients had overt clinical pancreatitis postoperatively. There was no positive correlation between the serum amylase level and the occurrence of pancreatitis (p greater than 0.05). Forty-two cases had a significant elevation of the amylase creatinine clearance ratio (ACCR) after CPB. However, there was no significant difference between the groups with pulsatile and nonpulsatile CPB (p greater than 0.05). Three patients (4{\%}) died in our series. The causes of death were heart failure in two and fulminant pancreatitis associated with low cardiac output in one. Although our experience in dealing with pancreatitis improved survival, mortality was still high (33.3{\%}) in our series. Nevertheless, there was no apparent correlation between mortality and postbypass hyperamylasemia (p greater than 0.05). Logistic regression analysis was used to analyze the risk factors of the occurrence of hyperamylasemia, and the analysis revealed that patients with coronary artery disease were susceptible to postbypass hyperamylasemia. Our studies indicate that the use of total serum amylase or ACCR to monitor for the occurrence of pancreatitis in postbypass patients is inadequate.(ABSTRACT TRUNCATED AT 250 WORDS)",
author = "H. Chang and Chung, {Y. T.} and Wu, {G. J.} and Hwang, {F. Y.} and Chen, {K. T.} and Peng, {W. L.} and Hung, {C. R.}",
year = "1992",
month = "1",
language = "English",
volume = "91",
pages = "34--40",
journal = "Journal of the Formosan Medical Association",
issn = "0929-6646",
publisher = "Elsevier Science Publishers B.V.",
number = "1",

}

TY - JOUR

T1 - Hyperamylasemia following cardiopulmonary bypass.

AU - Chang, H.

AU - Chung, Y. T.

AU - Wu, G. J.

AU - Hwang, F. Y.

AU - Chen, K. T.

AU - Peng, W. L.

AU - Hung, C. R.

PY - 1992/1

Y1 - 1992/1

N2 - In order to study the occurrence of postbypass hyperamylasemia, 75 patients undergoing cardiopulmonary bypass (CPB) were studied from March 1989 to January 1990. There were 49 males and 26 females. Among them, 27 had congenital heart disease, 30 had valvular disease, and 18 had coronary artery disease. There were 27 patients with at least one elevated serum amylase sample after operation. Thus, the overall incidence of hyperamylasemia was 36%. As compared with the preoperative data (1.3%), there was a statistically significant difference in the occurrence of hyperamylasemia (p less than 0.05). Three patients had overt clinical pancreatitis postoperatively. There was no positive correlation between the serum amylase level and the occurrence of pancreatitis (p greater than 0.05). Forty-two cases had a significant elevation of the amylase creatinine clearance ratio (ACCR) after CPB. However, there was no significant difference between the groups with pulsatile and nonpulsatile CPB (p greater than 0.05). Three patients (4%) died in our series. The causes of death were heart failure in two and fulminant pancreatitis associated with low cardiac output in one. Although our experience in dealing with pancreatitis improved survival, mortality was still high (33.3%) in our series. Nevertheless, there was no apparent correlation between mortality and postbypass hyperamylasemia (p greater than 0.05). Logistic regression analysis was used to analyze the risk factors of the occurrence of hyperamylasemia, and the analysis revealed that patients with coronary artery disease were susceptible to postbypass hyperamylasemia. Our studies indicate that the use of total serum amylase or ACCR to monitor for the occurrence of pancreatitis in postbypass patients is inadequate.(ABSTRACT TRUNCATED AT 250 WORDS)

AB - In order to study the occurrence of postbypass hyperamylasemia, 75 patients undergoing cardiopulmonary bypass (CPB) were studied from March 1989 to January 1990. There were 49 males and 26 females. Among them, 27 had congenital heart disease, 30 had valvular disease, and 18 had coronary artery disease. There were 27 patients with at least one elevated serum amylase sample after operation. Thus, the overall incidence of hyperamylasemia was 36%. As compared with the preoperative data (1.3%), there was a statistically significant difference in the occurrence of hyperamylasemia (p less than 0.05). Three patients had overt clinical pancreatitis postoperatively. There was no positive correlation between the serum amylase level and the occurrence of pancreatitis (p greater than 0.05). Forty-two cases had a significant elevation of the amylase creatinine clearance ratio (ACCR) after CPB. However, there was no significant difference between the groups with pulsatile and nonpulsatile CPB (p greater than 0.05). Three patients (4%) died in our series. The causes of death were heart failure in two and fulminant pancreatitis associated with low cardiac output in one. Although our experience in dealing with pancreatitis improved survival, mortality was still high (33.3%) in our series. Nevertheless, there was no apparent correlation between mortality and postbypass hyperamylasemia (p greater than 0.05). Logistic regression analysis was used to analyze the risk factors of the occurrence of hyperamylasemia, and the analysis revealed that patients with coronary artery disease were susceptible to postbypass hyperamylasemia. Our studies indicate that the use of total serum amylase or ACCR to monitor for the occurrence of pancreatitis in postbypass patients is inadequate.(ABSTRACT TRUNCATED AT 250 WORDS)

UR - http://www.scopus.com/inward/record.url?scp=0026444228&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026444228&partnerID=8YFLogxK

M3 - Article

VL - 91

SP - 34

EP - 40

JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

SN - 0929-6646

IS - 1

ER -