Abstract
After the administration of iproniazid to rabbits and rats, a harmful metabolite, hydrazine, was detected in urine and plasma by means of gas chromatography and gas chromatography-mass spectrometry. The amount of excreted hydrazine from iproniazid was much more than that from isoniazid.
| Original language | English |
|---|---|
| Pages (from-to) | 620-627 |
| Number of pages | 8 |
| Journal | Journal of Pharmacobio-Dynamics |
| Volume | 3 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 1980 |
| Externally published | Yes |
Keywords
- animal urine and plasma
- GC and GC-MS analyses
- hydrazine formation
- intravenous and subcutaneous administration
- iproniazid
- oral
ASJC Scopus subject areas
- Pharmacology