After the administration of iproniazid to rabbits and rats, a harmful metabolite, hydrazine, was detected in urine and plasma by means of gas chromatography and gas chromatography-mass spectrometry. The amount of excreted hydrazine from iproniazid was much more than that from isoniazid.
- animal urine and plasma
- GC and GC-MS analyses
- hydrazine formation
- intravenous and subcutaneous administration
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