Hydrazine formation from iproniazid.

Hsu Kuang-Yang, Noda Atsuko, Iguchi Sadao

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

After the administration of iproniazid to rabbits and rats, a harmful metabolite, hydrazine, was detected in urine and plasma by means of gas chromatography and gas chromatography-mass spectrometry. The amount of excreted hydrazine from iproniazid was much more than that from isoniazid.

Original languageEnglish
Pages (from-to)620-627
Number of pages8
JournalJournal of Pharmacobio-Dynamics
Volume3
Issue number11
DOIs
Publication statusPublished - 1980
Externally publishedYes

Keywords

  • animal urine and plasma
  • GC and GC-MS analyses
  • hydrazine formation
  • intravenous and subcutaneous administration
  • iproniazid
  • oral

ASJC Scopus subject areas

  • Pharmacology

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