Hydrazine formation from iproniazid.

Hsu Kuang-Yang, Noda Atsuko, Iguchi Sadao

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

After the administration of iproniazid to rabbits and rats, a harmful metabolite, hydrazine, was detected in urine and plasma by means of gas chromatography and gas chromatography-mass spectrometry. The amount of excreted hydrazine from iproniazid was much more than that from isoniazid.

Original languageEnglish
Pages (from-to)620-627
Number of pages8
JournalJournal of Pharmacobio-Dynamics
Volume3
Issue number11
DOIs
Publication statusPublished - 1980
Externally publishedYes

Fingerprint

hydrazine
Iproniazid
Plasma Gases
Isoniazid
Gas Chromatography
Gas Chromatography-Mass Spectrometry
Urine
Rabbits

Keywords

  • animal urine and plasma
  • GC and GC-MS analyses
  • hydrazine formation
  • intravenous and subcutaneous administration
  • iproniazid
  • oral

ASJC Scopus subject areas

  • Pharmacology

Cite this

Hydrazine formation from iproniazid. / Kuang-Yang, Hsu; Atsuko, Noda; Sadao, Iguchi.

In: Journal of Pharmacobio-Dynamics, Vol. 3, No. 11, 1980, p. 620-627.

Research output: Contribution to journalArticle

Kuang-Yang, H, Atsuko, N & Sadao, I 1980, 'Hydrazine formation from iproniazid.', Journal of Pharmacobio-Dynamics, vol. 3, no. 11, pp. 620-627. https://doi.org/10.1248/bpb1978.3.620
Kuang-Yang, Hsu ; Atsuko, Noda ; Sadao, Iguchi. / Hydrazine formation from iproniazid. In: Journal of Pharmacobio-Dynamics. 1980 ; Vol. 3, No. 11. pp. 620-627.
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