Human umbilical cord mesenchymal stem cells suppress breast cancer tumourigenesis through direct cell-cell contact and internalization

Kuo Ching Chao, Hui Tai Yang, Min Wei Chen

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The purpose of this study was to investigate how human umbilical cord mesenchymal stem cells (HUMSCs) affect breast cancer tumourigenesis. To observe the influence of HUMSCs on tumourigenesis in vitro, we performed a co-culture of MDA MB-231 breast cancer cells with HUMSCs, and a result of HUMSCs on tumourigenesis in vivo was achieved by injection of HUMSCs into nonobese diabetic/severe combined immunodeficient mice following tumour establishment with MDA-MB231. During the co-culture, apoptosis of MDA-MB231 was noted, which was driven either by binding with HUMSC through direct cell-cell contact or by formation of a novel cell-in-cell phenomenon after internalization of HUMSC. Also, treatment with HUMSC injection was efficacious in both in situ and metastatic breast cancers in the animal models. Since HUMSCs were proved to efficaciously suppress breast cancer tumourigenesis both in vitro and in vivo, it is our expectation that treatment with HUMSCs can be a viable therapy for breast cancer in the near future. In addition, we share a new point of view on the role of HUMSCs in foetal development during pregnancy.

Original languageEnglish
Pages (from-to)1803-1815
Number of pages13
JournalJournal of Cellular and Molecular Medicine
Volume16
Issue number8
DOIs
Publication statusPublished - Aug 2012
Externally publishedYes

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Umbilical Cord
Mesenchymal Stromal Cells
Breast Neoplasms
Coculture Techniques
Injections
SCID Mice
Fetal Development
Therapeutics
Animal Models
Apoptosis
Pregnancy

Keywords

  • Breast cancer
  • Cell-in-cell
  • Human umbilical cord mesenchymal stem cell

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine

Cite this

Human umbilical cord mesenchymal stem cells suppress breast cancer tumourigenesis through direct cell-cell contact and internalization. / Chao, Kuo Ching; Yang, Hui Tai; Chen, Min Wei.

In: Journal of Cellular and Molecular Medicine, Vol. 16, No. 8, 08.2012, p. 1803-1815.

Research output: Contribution to journalArticle

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