Human papillomaviruses in oral squamous cell carcinoma and pre-cancerous lesions detected by PCR-based gene-chip array

Chin Wan Luo, Cheng Hsiung Roan, Chung Ji Liu

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Human papillomavirus (HPV) infection is a significant risk factor for uterine cervical carcinoma. Many studies have also demonstrated the presence of HPV in oral epithelia tissue, but the role of HPV infection in oral squamous cell carcinoma (OSCC) is still controversial. The aim of this study was to determine the frequency and type of HPV in OSCC and oral pre-cancerous lesions. DNA samples were collected by cytobrushing from 51 patients with OSCC, 46 with oral pre-cancerous lesions and 90 normal controls. Nested polymerase chain reaction and gene-chip arrays were used to identify the HPV types in the samples. In pre-cancerous lesions, there was a higher frequency of HPV of any type (14/46, OR = 2.844, CI = 1.186-6.816, P = 0.0216) and of low-risk HPV types (9/46, OR = 5.529, CI = 1.597-19.14, P = 0.0096) than in control samples. The prevalence of high-risk types was significantly higher in OSCC than in control lesions (11/51 vs 8/90, OR = 2.819, CI = 1.051-7.558, P = 0.0420) but this was not the case for HPV of any type (13/51 vs 12/90, OR = 2.244, CI = 0.9266-5.337, P = 0.1066). High-risk HPV types are prevalent in OSCC and may play a role in its progression, while low-risk types are associated with oral pre-cancerous lesions.

Original languageEnglish
Pages (from-to)153-158
Number of pages6
JournalInternational Journal of Oral and Maxillofacial Surgery
Volume36
Issue number2
DOIs
Publication statusPublished - Feb 2007

Keywords

  • cytobrush
  • gene-chip
  • genotype
  • human papillomavirus
  • mouth neoplasm

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery
  • Dentistry(all)

Fingerprint Dive into the research topics of 'Human papillomaviruses in oral squamous cell carcinoma and pre-cancerous lesions detected by PCR-based gene-chip array'. Together they form a unique fingerprint.

  • Cite this