Abstract
To evaluate whether human papillomavirus (HPV) genotyping for the selected oncogenic HPV types can improve the efficacy of HPV DNA testing in predicting cervical intraepithelial neoplasia (CIN 2/3) in women with mildly abnormal Pap results, we compared HPV DNA testing and HPV genotyping for eight oncogenic types (16, 18, 31, 33, 35, 45, 52 and 58) in Pap specimens with abnormal results (HSIL, 20 cases; LSIL, 42 cases; ASC-US, 94 cases) and follow-up biopsies. Using consensus primer-mediated PCR assays, HPV DNA was detected in 90% (18/20) of HSIL, 95% (40/42) of LSIL and 64% (60/94) of ASC-US cases. HPV DNA positivity was significantly associated with CIN 2/3/carcinoma (P
Original language | English |
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Pages (from-to) | 1037-1043 |
Number of pages | 7 |
Journal | Modern Pathology |
Volume | 21 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 2008 |
Keywords
- ASCUS
- Genotyping
- HPV
- HSIL
- Human papillomavirus
- LSIL
ASJC Scopus subject areas
- Pathology and Forensic Medicine