Human papillomavirus genotyping for the eight oncogenic types can improve specificity of HPV testing in women with mildly abnormal Pap results

Ming Guo, Ching Yu Lin, Yun Gong, David E. Cogdell, Wei Zhang, E. Lin, Nour Sneige

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

To evaluate whether human papillomavirus (HPV) genotyping for the selected oncogenic HPV types can improve the efficacy of HPV DNA testing in predicting cervical intraepithelial neoplasia (CIN 2/3) in women with mildly abnormal Pap results, we compared HPV DNA testing and HPV genotyping for eight oncogenic types (16, 18, 31, 33, 35, 45, 52 and 58) in Pap specimens with abnormal results (HSIL, 20 cases; LSIL, 42 cases; ASC-US, 94 cases) and follow-up biopsies. Using consensus primer-mediated PCR assays, HPV DNA was detected in 90% (18/20) of HSIL, 95% (40/42) of LSIL and 64% (60/94) of ASC-US cases. HPV DNA positivity was significantly associated with CIN 2/3/carcinoma (P

Original languageEnglish
Pages (from-to)1037-1043
Number of pages7
JournalModern Pathology
Volume21
Issue number8
DOIs
Publication statusPublished - Aug 2008

Keywords

  • ASCUS
  • Genotyping
  • HPV
  • HSIL
  • Human papillomavirus
  • LSIL

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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