Abstract
To evaluate whether human papillomavirus (HPV) genotyping for the selected oncogenic HPV types can improve the efficacy of HPV DNA testing in predicting cervical intraepithelial neoplasia (CIN 2/3) in women with mildly abnormal Pap results, we compared HPV DNA testing and HPV genotyping for eight oncogenic types (16, 18, 31, 33, 35, 45, 52 and 58) in Pap specimens with abnormal results (HSIL, 20 cases; LSIL, 42 cases; ASC-US, 94 cases) and follow-up biopsies. Using consensus primer-mediated PCR assays, HPV DNA was detected in 90% (18/20) of HSIL, 95% (40/42) of LSIL and 64% (60/94) of ASC-US cases. HPV DNA positivity was significantly associated with CIN 2/3/carcinoma (P
| Original language | English |
|---|---|
| Pages (from-to) | 1037-1043 |
| Number of pages | 7 |
| Journal | Modern Pathology |
| Volume | 21 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2008 |
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Keywords
- ASCUS
- Genotyping
- HPV
- HSIL
- Human papillomavirus
- LSIL
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Human papillomavirus genotyping for the eight oncogenic types can improve specificity of HPV testing in women with mildly abnormal Pap results. / Guo, Ming; Lin, Ching Yu; Gong, Yun; Cogdell, David E.; Zhang, Wei; Lin, E.; Sneige, Nour.
In: Modern Pathology, Vol. 21, No. 8, 08.2008, p. 1037-1043.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Human papillomavirus genotyping for the eight oncogenic types can improve specificity of HPV testing in women with mildly abnormal Pap results
AU - Guo, Ming
AU - Lin, Ching Yu
AU - Gong, Yun
AU - Cogdell, David E.
AU - Zhang, Wei
AU - Lin, E.
AU - Sneige, Nour
PY - 2008/8
Y1 - 2008/8
N2 - To evaluate whether human papillomavirus (HPV) genotyping for the selected oncogenic HPV types can improve the efficacy of HPV DNA testing in predicting cervical intraepithelial neoplasia (CIN 2/3) in women with mildly abnormal Pap results, we compared HPV DNA testing and HPV genotyping for eight oncogenic types (16, 18, 31, 33, 35, 45, 52 and 58) in Pap specimens with abnormal results (HSIL, 20 cases; LSIL, 42 cases; ASC-US, 94 cases) and follow-up biopsies. Using consensus primer-mediated PCR assays, HPV DNA was detected in 90% (18/20) of HSIL, 95% (40/42) of LSIL and 64% (60/94) of ASC-US cases. HPV DNA positivity was significantly associated with CIN 2/3/carcinoma (P
AB - To evaluate whether human papillomavirus (HPV) genotyping for the selected oncogenic HPV types can improve the efficacy of HPV DNA testing in predicting cervical intraepithelial neoplasia (CIN 2/3) in women with mildly abnormal Pap results, we compared HPV DNA testing and HPV genotyping for eight oncogenic types (16, 18, 31, 33, 35, 45, 52 and 58) in Pap specimens with abnormal results (HSIL, 20 cases; LSIL, 42 cases; ASC-US, 94 cases) and follow-up biopsies. Using consensus primer-mediated PCR assays, HPV DNA was detected in 90% (18/20) of HSIL, 95% (40/42) of LSIL and 64% (60/94) of ASC-US cases. HPV DNA positivity was significantly associated with CIN 2/3/carcinoma (P
KW - ASCUS
KW - Genotyping
KW - HPV
KW - HSIL
KW - Human papillomavirus
KW - LSIL
UR - http://www.scopus.com/inward/record.url?scp=48749109523&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=48749109523&partnerID=8YFLogxK
U2 - 10.1038/modpathol.2008.93
DO - 10.1038/modpathol.2008.93
M3 - Article
C2 - 18500260
AN - SCOPUS:48749109523
VL - 21
SP - 1037
EP - 1043
JO - Modern Pathology
JF - Modern Pathology
SN - 0893-3952
IS - 8
ER -