Human papillomavirus genotyping for the eight oncogenic types can improve specificity of HPV testing in women with mildly abnormal Pap results

Ming Guo; Ching Yu Lin; Yun Gong; David E. Cogdell; Wei Zhang; E. Lin; Nour Sneige

doi:10.1038/modpathol.2008.93

Human papillomavirus genotyping for the eight oncogenic types can improve specificity of HPV testing in women with mildly abnormal Pap results

Ming Guo, Ching Yu Lin, Yun Gong, David E. Cogdell, Wei Zhang, E. Lin, Nour Sneige

School of Medical Laboratory Science and Biotechnology

Research output: Contribution to journal › Article

14 Citations (Scopus)

Abstract

To evaluate whether human papillomavirus (HPV) genotyping for the selected oncogenic HPV types can improve the efficacy of HPV DNA testing in predicting cervical intraepithelial neoplasia (CIN 2/3) in women with mildly abnormal Pap results, we compared HPV DNA testing and HPV genotyping for eight oncogenic types (16, 18, 31, 33, 35, 45, 52 and 58) in Pap specimens with abnormal results (HSIL, 20 cases; LSIL, 42 cases; ASC-US, 94 cases) and follow-up biopsies. Using consensus primer-mediated PCR assays, HPV DNA was detected in 90% (18/20) of HSIL, 95% (40/42) of LSIL and 64% (60/94) of ASC-US cases. HPV DNA positivity was significantly associated with CIN 2/3/carcinoma (P

Original language	English
Pages (from-to)	1037-1043
Number of pages	7
Journal	Modern Pathology
Volume	21
Issue number	8
DOIs	https://doi.org/10.1038/modpathol.2008.93
Publication status	Published - Aug 2008

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Keywords

ASCUS
Genotyping
HPV
HSIL
Human papillomavirus
LSIL

ASJC Scopus subject areas

Pathology and Forensic Medicine

Cite this

Guo, M., Lin, C. Y., Gong, Y., Cogdell, D. E., Zhang, W., Lin, E., & Sneige, N. (2008). Human papillomavirus genotyping for the eight oncogenic types can improve specificity of HPV testing in women with mildly abnormal Pap results. Modern Pathology, 21(8), 1037-1043. https://doi.org/10.1038/modpathol.2008.93

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abstract = "To evaluate whether human papillomavirus (HPV) genotyping for the selected oncogenic HPV types can improve the efficacy of HPV DNA testing in predicting cervical intraepithelial neoplasia (CIN 2/3) in women with mildly abnormal Pap results, we compared HPV DNA testing and HPV genotyping for eight oncogenic types (16, 18, 31, 33, 35, 45, 52 and 58) in Pap specimens with abnormal results (HSIL, 20 cases; LSIL, 42 cases; ASC-US, 94 cases) and follow-up biopsies. Using consensus primer-mediated PCR assays, HPV DNA was detected in 90% (18/20) of HSIL, 95% (40/42) of LSIL and 64% (60/94) of ASC-US cases. HPV DNA positivity was significantly associated with CIN 2/3/carcinoma (P",

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10.1038/modpathol.2008.93