Human papillomavirus genotyping as a predictor of high-grade cervical dysplasia in women with mildly cytologic abnormalities: A two-year follow-up report

Lee Wen Huang, Yu Hung Lin, Hun Shan Pan, Kok Min Seow, Ching Yu Lin

Research output: Contribution to journalArticle

4 Citations (Scopus)


High-risk human papillomavirus (HR-HPV) DNA testing has emerged as another testing modality for women with mildly cytologic abnormalities. We conducted a two-year follow-up study of 108 women with mildly abnormal cervical cytology for detection of CIN 2/3. A cervical swab sample was obtained for HPV genotyping by a HPV blot and histologic follow-up results were correlated with HR-HPV types. Of the 108 cases, 93 (86.1%) were positive for HR-HPV DNA. HPV-16 was detected in 45.1% of patients. CIN grade 2 or 3 was confirmed in 25 (23.1%) of the 108 women during the two-year follow-up period. The two-year cumulative incidence rates of CIN 2/3 were 38.6% (17/44) among HPV-16- positive women, but only 5.6% among HR-HPV-positive women without HPV-16 or HPV-18. The sensitivity of a positive HPV-16 test for CIN 2/3 was 68.0%, the specificity was 67.5%. Our results demonstrated that the type-specific HPV-16 test increased sensitivity of detecting high-grade cervical dysplasia for women who have mildly cytologic abnormalities. The implication of the present findings is that HPV genotyping may identify women with the greatest risk of high-grade CIN.

Original languageEnglish
Pages (from-to)673-677
Number of pages5
JournalDiagnostic Cytopathology
Issue number8
Publication statusPublished - Aug 2012



  • cervical intraepithelial neoplasia
  • genotyping
  • human papillomavirus

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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