Human papillomaviral load changes in low-grade squamous intraepithelial lesions of the uterine cervix

C. M. Ho, W. F. Cheng, T. Y. Chu, C. A. Chen, M. H. Chuang, S. F. Chang, C. Y. Hsieh

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

To better predict risk of progression of low-grade squamous intraepithelial lesions (LSILs) of the uterine cervix in women with human papillomavirus (HPV) infections, 294 baseline cervical specimens from women with LSILs were evaluated. Specimens were tested for HPV DNA using hybrid capture 2 (HC2) and PCR-reverse line blotting. 65 LSILs with HPV DNA types 16, 18, 52, or 58 were examined for physical status, E2/E6 ratio and viral load at two time points, along with patient age. Women with LSILs whose viral loads increased between baseline and 6 month follow-up had a 45% risk of developing HSIL (OR = 7.6, 95% CI = 1.9-29.4, P

Original languageEnglish
Pages (from-to)1384-1389
Number of pages6
JournalBritish Journal of Cancer
Volume95
Issue number10
DOIs
Publication statusPublished - Nov 20 2006

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Cervix Uteri
Viral Load
Papillomavirus Infections
Human papillomavirus 16
DNA
Squamous Intraepithelial Lesions of the Cervix
Polymerase Chain Reaction

Keywords

  • HPV
  • Hybrid capture 2
  • Integration
  • Low-grade squamous intraepithelial lesions
  • Viral load

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Human papillomaviral load changes in low-grade squamous intraepithelial lesions of the uterine cervix. / Ho, C. M.; Cheng, W. F.; Chu, T. Y.; Chen, C. A.; Chuang, M. H.; Chang, S. F.; Hsieh, C. Y.

In: British Journal of Cancer, Vol. 95, No. 10, 20.11.2006, p. 1384-1389.

Research output: Contribution to journalArticle

Ho, C. M. ; Cheng, W. F. ; Chu, T. Y. ; Chen, C. A. ; Chuang, M. H. ; Chang, S. F. ; Hsieh, C. Y. / Human papillomaviral load changes in low-grade squamous intraepithelial lesions of the uterine cervix. In: British Journal of Cancer. 2006 ; Vol. 95, No. 10. pp. 1384-1389.
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