Abstract
To better predict risk of progression of low-grade squamous intraepithelial lesions (LSILs) of the uterine cervix in women with human papillomavirus (HPV) infections, 294 baseline cervical specimens from women with LSILs were evaluated. Specimens were tested for HPV DNA using hybrid capture 2 (HC2) and PCR-reverse line blotting. 65 LSILs with HPV DNA types 16, 18, 52, or 58 were examined for physical status, E2/E6 ratio and viral load at two time points, along with patient age. Women with LSILs whose viral loads increased between baseline and 6 month follow-up had a 45% risk of developing HSIL (OR = 7.6, 95% CI = 1.9-29.4, P
| Original language | English |
|---|---|
| Pages (from-to) | 1384-1389 |
| Number of pages | 6 |
| Journal | British Journal of Cancer |
| Volume | 95 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Nov 20 2006 |
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Keywords
- HPV
- Hybrid capture 2
- Integration
- Low-grade squamous intraepithelial lesions
- Viral load
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Human papillomaviral load changes in low-grade squamous intraepithelial lesions of the uterine cervix. / Ho, C. M.; Cheng, W. F.; Chu, T. Y.; Chen, C. A.; Chuang, M. H.; Chang, S. F.; Hsieh, C. Y.
In: British Journal of Cancer, Vol. 95, No. 10, 20.11.2006, p. 1384-1389.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Human papillomaviral load changes in low-grade squamous intraepithelial lesions of the uterine cervix
AU - Ho, C. M.
AU - Cheng, W. F.
AU - Chu, T. Y.
AU - Chen, C. A.
AU - Chuang, M. H.
AU - Chang, S. F.
AU - Hsieh, C. Y.
PY - 2006/11/20
Y1 - 2006/11/20
N2 - To better predict risk of progression of low-grade squamous intraepithelial lesions (LSILs) of the uterine cervix in women with human papillomavirus (HPV) infections, 294 baseline cervical specimens from women with LSILs were evaluated. Specimens were tested for HPV DNA using hybrid capture 2 (HC2) and PCR-reverse line blotting. 65 LSILs with HPV DNA types 16, 18, 52, or 58 were examined for physical status, E2/E6 ratio and viral load at two time points, along with patient age. Women with LSILs whose viral loads increased between baseline and 6 month follow-up had a 45% risk of developing HSIL (OR = 7.6, 95% CI = 1.9-29.4, P
AB - To better predict risk of progression of low-grade squamous intraepithelial lesions (LSILs) of the uterine cervix in women with human papillomavirus (HPV) infections, 294 baseline cervical specimens from women with LSILs were evaluated. Specimens were tested for HPV DNA using hybrid capture 2 (HC2) and PCR-reverse line blotting. 65 LSILs with HPV DNA types 16, 18, 52, or 58 were examined for physical status, E2/E6 ratio and viral load at two time points, along with patient age. Women with LSILs whose viral loads increased between baseline and 6 month follow-up had a 45% risk of developing HSIL (OR = 7.6, 95% CI = 1.9-29.4, P
KW - HPV
KW - Hybrid capture 2
KW - Integration
KW - Low-grade squamous intraepithelial lesions
KW - Viral load
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U2 - 10.1038/sj.bjc.6603430
DO - 10.1038/sj.bjc.6603430
M3 - Article
VL - 95
SP - 1384
EP - 1389
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - 10
ER -