Human papillomaviral load changes in low-grade squamous intraepithelial lesions of the uterine cervix

C. M. Ho, W. F. Cheng, T. Y. Chu, C. A. Chen, M. H. Chuang, S. F. Chang, C. Y. Hsieh

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

To better predict risk of progression of low-grade squamous intraepithelial lesions (LSILs) of the uterine cervix in women with human papillomavirus (HPV) infections, 294 baseline cervical specimens from women with LSILs were evaluated. Specimens were tested for HPV DNA using hybrid capture 2 (HC2) and PCR-reverse line blotting. 65 LSILs with HPV DNA types 16, 18, 52, or 58 were examined for physical status, E2/E6 ratio and viral load at two time points, along with patient age. Women with LSILs whose viral loads increased between baseline and 6 month follow-up had a 45% risk of developing HSIL (OR = 7.6, 95% CI = 1.9-29.4, P

Original languageEnglish
Pages (from-to)1384-1389
Number of pages6
JournalBritish Journal of Cancer
Volume95
Issue number10
DOIs
Publication statusPublished - Nov 20 2006

Keywords

  • HPV
  • Hybrid capture 2
  • Integration
  • Low-grade squamous intraepithelial lesions
  • Viral load

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Human papillomaviral load changes in low-grade squamous intraepithelial lesions of the uterine cervix'. Together they form a unique fingerprint.

  • Cite this