Human papillomaviral load changes in low-grade squamous intraepithelial lesions of the uterine cervix

C. M. Ho; W. F. Cheng; T. Y. Chu; C. A. Chen; M. H. Chuang; S. F. Chang; C. Y. Hsieh

doi:10.1038/sj.bjc.6603430

Human papillomaviral load changes in low-grade squamous intraepithelial lesions of the uterine cervix

C. M. Ho, W. F. Cheng, T. Y. Chu, C. A. Chen, M. H. Chuang, S. F. Chang, C. Y. Hsieh

Graduate Institute of Medical Sciences

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

To better predict risk of progression of low-grade squamous intraepithelial lesions (LSILs) of the uterine cervix in women with human papillomavirus (HPV) infections, 294 baseline cervical specimens from women with LSILs were evaluated. Specimens were tested for HPV DNA using hybrid capture 2 (HC2) and PCR-reverse line blotting. 65 LSILs with HPV DNA types 16, 18, 52, or 58 were examined for physical status, E2/E6 ratio and viral load at two time points, along with patient age. Women with LSILs whose viral loads increased between baseline and 6 month follow-up had a 45% risk of developing HSIL (OR = 7.6, 95% CI = 1.9-29.4, P

Original language	English
Pages (from-to)	1384-1389
Number of pages	6
Journal	British Journal of Cancer
Volume	95
Issue number	10
DOIs	https://doi.org/10.1038/sj.bjc.6603430
Publication status	Published - Nov 20 2006

Keywords

HPV
Hybrid capture 2
Integration
Low-grade squamous intraepithelial lesions
Viral load

ASJC Scopus subject areas

Cancer Research
Oncology

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abstract = "To better predict risk of progression of low-grade squamous intraepithelial lesions (LSILs) of the uterine cervix in women with human papillomavirus (HPV) infections, 294 baseline cervical specimens from women with LSILs were evaluated. Specimens were tested for HPV DNA using hybrid capture 2 (HC2) and PCR-reverse line blotting. 65 LSILs with HPV DNA types 16, 18, 52, or 58 were examined for physical status, E2/E6 ratio and viral load at two time points, along with patient age. Women with LSILs whose viral loads increased between baseline and 6 month follow-up had a 45% risk of developing HSIL (OR = 7.6, 95% CI = 1.9-29.4, P ",

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AU - Chang, S. F.

AU - Hsieh, C. Y.

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