Human metapneumovirus and community-acquired pneumonia in children

Pen Yi Lin, Tzou Yien Lin, Yhu Chering Huang, Kuo Chien Tsao, Ya Ling Huang

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Human metapneumovirus (hMPV) was first recognized in the Netherlands in 2001 from nasopharyngeal aspirate samples and was associated with respiratory tract illness in the pediatric population. This was the first report of metapneumovirus infections in community-acquired pneumonia in Taiwan. Methods: A total of 116 nasopharyngeal aspirate samples from patients with community-acquired pneumonia was examined by reverse transcriptase polymerase chain reaction (RT-PCR). Other respiratory tract pathogens were also examined. The clinical characteristics and laboratory data were analyzed. Results: Out of the 116 patients, potential causative agents were detected in 95 (81.9%) patients. A total of six human metapneumovirus RT-PCR positive samples was identified. All of these had evidence of coinfection with bacteria (3 Streptococcus pneumoniae, 2 Mycoplasma pneumoniae, 1 Chlamydia pneumoniae). Coinfection with other respiratory viruses was also observed in two cases (1 influenza A, 1 parainfluenza type 3). The age distribution was seven to 11 years except for one patient who was two years of age (Case 1). The most common clinical findings were fever (6/6, 100%), cough (6/6,100%), rhinorrhea (5/6, 83.3%), rales (5/6, 83.3%) and wheezing (1/6, 16.7%). Chest radiographs revealed four with lobar patches and two with interstitial infiltrations. The mean duration of hospital stay was 5.5 ± 2.8 days. All patients made a complete recovery. Conclusions: hMPV was identified in 5.2% of patients with community-acquired pneumonia. Our data showed a high rate of coinfection with hMPV in community-acquired pneumonia. Human metapneumovirus infection, like other respiratory viruses, may predispose to secondary bacterial pneumonia.

Original languageEnglish
Pages (from-to)683-688
Number of pages6
JournalChang Gung Medical Journal
Volume28
Issue number10
Publication statusPublished - Oct 2005
Externally publishedYes

Fingerprint

Metapneumovirus
Pneumonia
Coinfection
Respiratory Sounds
Reverse Transcriptase Polymerase Chain Reaction
Respiratory System
Viruses
Community-Acquired Infections
Bacterial Pneumonia
Paramyxoviridae Infections
Chlamydophila pneumoniae
Mycoplasma pneumoniae
Age Distribution
Streptococcus pneumoniae
Taiwan
Cough
Netherlands
Human Influenza
Length of Stay
Fever

Keywords

  • Community-acquired pneumonia
  • Human metapneumovirus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lin, P. Y., Lin, T. Y., Huang, Y. C., Tsao, K. C., & Huang, Y. L. (2005). Human metapneumovirus and community-acquired pneumonia in children. Chang Gung Medical Journal, 28(10), 683-688.

Human metapneumovirus and community-acquired pneumonia in children. / Lin, Pen Yi; Lin, Tzou Yien; Huang, Yhu Chering; Tsao, Kuo Chien; Huang, Ya Ling.

In: Chang Gung Medical Journal, Vol. 28, No. 10, 10.2005, p. 683-688.

Research output: Contribution to journalArticle

Lin, PY, Lin, TY, Huang, YC, Tsao, KC & Huang, YL 2005, 'Human metapneumovirus and community-acquired pneumonia in children', Chang Gung Medical Journal, vol. 28, no. 10, pp. 683-688.
Lin, Pen Yi ; Lin, Tzou Yien ; Huang, Yhu Chering ; Tsao, Kuo Chien ; Huang, Ya Ling. / Human metapneumovirus and community-acquired pneumonia in children. In: Chang Gung Medical Journal. 2005 ; Vol. 28, No. 10. pp. 683-688.
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