Human-leukocyte antigen class i Cw 1502 and Class II DR 0301 genotypes are associated with resistance to severe acute respiratory syndrome (SARS) infection

Sheng Fan Wang, Kuan Hsuan Chen, Marcelo Chen, Wen Yi Li, Yen Ju Chen, Ching Han Tsao, Muh Yong Yen, Jason C. Huang, Yi Ming Arthur Chen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

One-hundred and thirty confirmed cases of severe acute respiratory syndrome (SARS) were recruited to evaluate their anti-SARS-coronavirus (CoV) antibody status and human leukocyte antigen (HLA) types in September 2006, 3y after the SARS outbreaks in Taiwan. Western blot assay showed that 6.9% of participants still had anti-spike and anti-nucleocapside antibodies. A case-control study of the association of HLA with SARS revealed that the HLA-Cw1502 and DR0301 alleles conferred resistance against SARS infection (p<0.05).

Original languageEnglish
Pages (from-to)421-426
Number of pages6
JournalViral Immunology
Volume24
Issue number5
DOIs
Publication statusPublished - Oct 1 2011
Externally publishedYes

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Severe Acute Respiratory Syndrome
HLA Antigens
Respiratory Tract Infections
Genotype
Coronavirus
Taiwan
Disease Outbreaks
Case-Control Studies
Anti-Idiotypic Antibodies
Western Blotting
Alleles
Antibodies

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Virology

Cite this

Human-leukocyte antigen class i Cw 1502 and Class II DR 0301 genotypes are associated with resistance to severe acute respiratory syndrome (SARS) infection. / Wang, Sheng Fan; Chen, Kuan Hsuan; Chen, Marcelo; Li, Wen Yi; Chen, Yen Ju; Tsao, Ching Han; Yen, Muh Yong; Huang, Jason C.; Chen, Yi Ming Arthur.

In: Viral Immunology, Vol. 24, No. 5, 01.10.2011, p. 421-426.

Research output: Contribution to journalArticle

Wang, Sheng Fan ; Chen, Kuan Hsuan ; Chen, Marcelo ; Li, Wen Yi ; Chen, Yen Ju ; Tsao, Ching Han ; Yen, Muh Yong ; Huang, Jason C. ; Chen, Yi Ming Arthur. / Human-leukocyte antigen class i Cw 1502 and Class II DR 0301 genotypes are associated with resistance to severe acute respiratory syndrome (SARS) infection. In: Viral Immunology. 2011 ; Vol. 24, No. 5. pp. 421-426.
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