Human ITCH is a coregulator of the hematopoietic transcription factor NF-E2

Xin Chen, Shau ching Wen, Michiko N. Fukuda, Narender R. Gavva, Duen wei Hsu, Tomoya O. Akama, Teresa Yang-Feng, C. K.James Shen

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


We have cloned a new protein that interacts with the hematopoietic DNA-binding transcription factor, p45/NF-E2, by screening a human erythroleukemia cell cDNA library with the yeast two-hybrid approach. Predicted peptide sequence and chromosomal mapping identified the cloned molecule to be the product of the human ortholog of the mouse Itch gene, which has been implicated previously in the regulation of growth and differentiation of erythroid and lymphoid cells. Transfection experiments indicate that this human ITCH protein can act as a transcriptional corepressor of p45/NF-E2. Our data provide novel insights into the functional roles of the mammalian ITCH proteins in the development of hematopoietic cell lineages.

Original languageEnglish
Pages (from-to)238-241
Number of pages4
Issue number2
Publication statusPublished - Apr 15 2001
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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