Human immunodeficiency virus (HIV) infection screening in a dialysis unit

Chia Chi Chou, Chia Yi Sun, Mai Szu Wu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background. Human immunodeficiency virus (HIV) screening is a routine for long-term hemodialysis patients because of a high risk for infection. Enzyme-immunoassay (EIA) is a simple tool for screening HIV, but clinically false-positive EIA is a frequent result. Other tests such as Western blot analysis (WB) and HIV DNA and RNA by polymerase chain reaction have better specificity and sensitivity, but they cannot be accessible in many dialysis units. Methods. Four hundred and four patients with end stage renal disease on long-term hemodialysis were screened with EIA for HIV antibodies. Repeated EIA was performed if the first test was positive result. WB was used as the confirmatory test. Results. Two persons initially showed a positive EIA pattern among the 404 patients, but nobody had positive WB test result later. Conclusion. The ratio of false-positive EIA results for screening HIV is relatively high in long-term hemodialysis patients. Further tests should be employed to confirm the diagnosis.

Original languageEnglish
Pages (from-to)459-461
Number of pages3
JournalRenal Failure
Volume29
Issue number4
DOIs
Publication statusPublished - May 2007
Externally publishedYes

Fingerprint

Virus Diseases
Immunoenzyme Techniques
Dialysis
HIV
Renal Dialysis
Western Blotting
DNA-Directed DNA Polymerase
DNA-Directed RNA Polymerases
Chronic Kidney Failure
Sensitivity and Specificity
Polymerase Chain Reaction
Antibodies
Infection

Keywords

  • Hemodialysis
  • HIV

ASJC Scopus subject areas

  • Nephrology

Cite this

Human immunodeficiency virus (HIV) infection screening in a dialysis unit. / Chou, Chia Chi; Sun, Chia Yi; Wu, Mai Szu.

In: Renal Failure, Vol. 29, No. 4, 05.2007, p. 459-461.

Research output: Contribution to journalArticle

Chou, Chia Chi ; Sun, Chia Yi ; Wu, Mai Szu. / Human immunodeficiency virus (HIV) infection screening in a dialysis unit. In: Renal Failure. 2007 ; Vol. 29, No. 4. pp. 459-461.
@article{c273a9e57a3644278adc3e9aea47f043,
title = "Human immunodeficiency virus (HIV) infection screening in a dialysis unit",
abstract = "Background. Human immunodeficiency virus (HIV) screening is a routine for long-term hemodialysis patients because of a high risk for infection. Enzyme-immunoassay (EIA) is a simple tool for screening HIV, but clinically false-positive EIA is a frequent result. Other tests such as Western blot analysis (WB) and HIV DNA and RNA by polymerase chain reaction have better specificity and sensitivity, but they cannot be accessible in many dialysis units. Methods. Four hundred and four patients with end stage renal disease on long-term hemodialysis were screened with EIA for HIV antibodies. Repeated EIA was performed if the first test was positive result. WB was used as the confirmatory test. Results. Two persons initially showed a positive EIA pattern among the 404 patients, but nobody had positive WB test result later. Conclusion. The ratio of false-positive EIA results for screening HIV is relatively high in long-term hemodialysis patients. Further tests should be employed to confirm the diagnosis.",
keywords = "Hemodialysis, HIV",
author = "Chou, {Chia Chi} and Sun, {Chia Yi} and Wu, {Mai Szu}",
year = "2007",
month = "5",
doi = "10.1080/08860220701260644",
language = "English",
volume = "29",
pages = "459--461",
journal = "Renal Failure",
issn = "0886-022X",
publisher = "Informa Healthcare",
number = "4",

}

TY - JOUR

T1 - Human immunodeficiency virus (HIV) infection screening in a dialysis unit

AU - Chou, Chia Chi

AU - Sun, Chia Yi

AU - Wu, Mai Szu

PY - 2007/5

Y1 - 2007/5

N2 - Background. Human immunodeficiency virus (HIV) screening is a routine for long-term hemodialysis patients because of a high risk for infection. Enzyme-immunoassay (EIA) is a simple tool for screening HIV, but clinically false-positive EIA is a frequent result. Other tests such as Western blot analysis (WB) and HIV DNA and RNA by polymerase chain reaction have better specificity and sensitivity, but they cannot be accessible in many dialysis units. Methods. Four hundred and four patients with end stage renal disease on long-term hemodialysis were screened with EIA for HIV antibodies. Repeated EIA was performed if the first test was positive result. WB was used as the confirmatory test. Results. Two persons initially showed a positive EIA pattern among the 404 patients, but nobody had positive WB test result later. Conclusion. The ratio of false-positive EIA results for screening HIV is relatively high in long-term hemodialysis patients. Further tests should be employed to confirm the diagnosis.

AB - Background. Human immunodeficiency virus (HIV) screening is a routine for long-term hemodialysis patients because of a high risk for infection. Enzyme-immunoassay (EIA) is a simple tool for screening HIV, but clinically false-positive EIA is a frequent result. Other tests such as Western blot analysis (WB) and HIV DNA and RNA by polymerase chain reaction have better specificity and sensitivity, but they cannot be accessible in many dialysis units. Methods. Four hundred and four patients with end stage renal disease on long-term hemodialysis were screened with EIA for HIV antibodies. Repeated EIA was performed if the first test was positive result. WB was used as the confirmatory test. Results. Two persons initially showed a positive EIA pattern among the 404 patients, but nobody had positive WB test result later. Conclusion. The ratio of false-positive EIA results for screening HIV is relatively high in long-term hemodialysis patients. Further tests should be employed to confirm the diagnosis.

KW - Hemodialysis

KW - HIV

UR - http://www.scopus.com/inward/record.url?scp=34248549053&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34248549053&partnerID=8YFLogxK

U2 - 10.1080/08860220701260644

DO - 10.1080/08860220701260644

M3 - Article

VL - 29

SP - 459

EP - 461

JO - Renal Failure

JF - Renal Failure

SN - 0886-022X

IS - 4

ER -