Human C-reactive protein (CRP) gene 1059 G > C polymorphism is associated with plasma CRP concentration in patients receiving coronary angiography

Dao Fu Dai, Fu Tien Chiang, Jiunn Lee Lin, Li Ying Huang, Chi Ling Chen, Chee Jen Chang, Ling Ping Lai, Kwan Lih Hsu, Chuen Den Tseng, Yung Zu Tseng, Juey Jen Hwang

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background/Purpose: Elevation of C-reactive protein (CRP) level is associated with increased risk of cardiovascular events. The 1059 G > C polymorphism in exon 2 of the CRP gene has been shown to affect plasma concentration of CRP. We want to elucidate the effect of this polymorphism on the development of coronary artery disease (CAD) among the Chinese population in Taiwan. Methods: We scrutinized 536 patients undergoing coronary angiography (365 patients with CAD and 171 controls with patent coronaries) and evaluated the association of CRP gene 1059 G > C polymorphism with CAD. Genotyping of the polymorphism was performed by polymerase chain reaction and MaeIII restriction enzyme digestion. Results: The CC genotype was associated with lower plasma CRP concentration (GG, 6.5±5.8, GC, 3.3 ± 4.4; CC, 2.3±3.1 mg/L; p= 0.02). Subjects with CAD or myocardial infarction (MI) had significantly higher plasma CRP concentration than that in controls (CAD vs. controls, 8.9±18.9 vs. 3.3±7.2 mg/L; p<0.001), while patients with MI showed higher CRP when compared to those with chronic stable angina (13.5 ±22.9 vs. 5.2±14.1 mg/L; p <0.001). However, this polymorphism was not associated with CAD in our population. Conclusion: Our data suggest that human CRP gene 1059 G>C polymorphism is associated with plasma CRP concentration among Chinese in Taiwan receiving coronary angiography.

Original languageEnglish
Pages (from-to)347-354
Number of pages8
JournalJournal of the Formosan Medical Association
Volume106
Issue number5
DOIs
Publication statusPublished - Jan 1 2007
Externally publishedYes

Fingerprint

Coronary Angiography
C-Reactive Protein
Blood Proteins
Coronary Artery Disease
Genes
Taiwan
Digestion
Exons
Genotype
Polymerase Chain Reaction
Enzymes
Population

Keywords

  • C-reactive protein
  • CAD
  • Coronary artery disease
  • CRP
  • Genetic polymorphism
  • MI
  • Myocardial infarction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Human C-reactive protein (CRP) gene 1059 G > C polymorphism is associated with plasma CRP concentration in patients receiving coronary angiography. / Dai, Dao Fu; Chiang, Fu Tien; Lin, Jiunn Lee; Huang, Li Ying; Chen, Chi Ling; Chang, Chee Jen; Lai, Ling Ping; Hsu, Kwan Lih; Tseng, Chuen Den; Tseng, Yung Zu; Hwang, Juey Jen.

In: Journal of the Formosan Medical Association, Vol. 106, No. 5, 01.01.2007, p. 347-354.

Research output: Contribution to journalArticle

Dai, Dao Fu ; Chiang, Fu Tien ; Lin, Jiunn Lee ; Huang, Li Ying ; Chen, Chi Ling ; Chang, Chee Jen ; Lai, Ling Ping ; Hsu, Kwan Lih ; Tseng, Chuen Den ; Tseng, Yung Zu ; Hwang, Juey Jen. / Human C-reactive protein (CRP) gene 1059 G > C polymorphism is associated with plasma CRP concentration in patients receiving coronary angiography. In: Journal of the Formosan Medical Association. 2007 ; Vol. 106, No. 5. pp. 347-354.
@article{8d89b090a02548449e7bfdfe938cfd93,
title = "Human C-reactive protein (CRP) gene 1059 G > C polymorphism is associated with plasma CRP concentration in patients receiving coronary angiography",
abstract = "Background/Purpose: Elevation of C-reactive protein (CRP) level is associated with increased risk of cardiovascular events. The 1059 G > C polymorphism in exon 2 of the CRP gene has been shown to affect plasma concentration of CRP. We want to elucidate the effect of this polymorphism on the development of coronary artery disease (CAD) among the Chinese population in Taiwan. Methods: We scrutinized 536 patients undergoing coronary angiography (365 patients with CAD and 171 controls with patent coronaries) and evaluated the association of CRP gene 1059 G > C polymorphism with CAD. Genotyping of the polymorphism was performed by polymerase chain reaction and MaeIII restriction enzyme digestion. Results: The CC genotype was associated with lower plasma CRP concentration (GG, 6.5±5.8, GC, 3.3 ± 4.4; CC, 2.3±3.1 mg/L; p= 0.02). Subjects with CAD or myocardial infarction (MI) had significantly higher plasma CRP concentration than that in controls (CAD vs. controls, 8.9±18.9 vs. 3.3±7.2 mg/L; p<0.001), while patients with MI showed higher CRP when compared to those with chronic stable angina (13.5 ±22.9 vs. 5.2±14.1 mg/L; p <0.001). However, this polymorphism was not associated with CAD in our population. Conclusion: Our data suggest that human CRP gene 1059 G>C polymorphism is associated with plasma CRP concentration among Chinese in Taiwan receiving coronary angiography.",
keywords = "C-reactive protein, CAD, Coronary artery disease, CRP, Genetic polymorphism, MI, Myocardial infarction, C-reactive protein, CAD, Coronary artery disease, CRP, Genetic polymorphism, MI, Myocardial infarction",
author = "Dai, {Dao Fu} and Chiang, {Fu Tien} and Lin, {Jiunn Lee} and Huang, {Li Ying} and Chen, {Chi Ling} and Chang, {Chee Jen} and Lai, {Ling Ping} and Hsu, {Kwan Lih} and Tseng, {Chuen Den} and Tseng, {Yung Zu} and Hwang, {Juey Jen}",
year = "2007",
month = "1",
day = "1",
doi = "10.1016/S0929-6646(09)60319-3",
language = "English",
volume = "106",
pages = "347--354",
journal = "Journal of the Formosan Medical Association",
issn = "0929-6646",
publisher = "Elsevier Science Publishers B.V.",
number = "5",

}

TY - JOUR

T1 - Human C-reactive protein (CRP) gene 1059 G > C polymorphism is associated with plasma CRP concentration in patients receiving coronary angiography

AU - Dai, Dao Fu

AU - Chiang, Fu Tien

AU - Lin, Jiunn Lee

AU - Huang, Li Ying

AU - Chen, Chi Ling

AU - Chang, Chee Jen

AU - Lai, Ling Ping

AU - Hsu, Kwan Lih

AU - Tseng, Chuen Den

AU - Tseng, Yung Zu

AU - Hwang, Juey Jen

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Background/Purpose: Elevation of C-reactive protein (CRP) level is associated with increased risk of cardiovascular events. The 1059 G > C polymorphism in exon 2 of the CRP gene has been shown to affect plasma concentration of CRP. We want to elucidate the effect of this polymorphism on the development of coronary artery disease (CAD) among the Chinese population in Taiwan. Methods: We scrutinized 536 patients undergoing coronary angiography (365 patients with CAD and 171 controls with patent coronaries) and evaluated the association of CRP gene 1059 G > C polymorphism with CAD. Genotyping of the polymorphism was performed by polymerase chain reaction and MaeIII restriction enzyme digestion. Results: The CC genotype was associated with lower plasma CRP concentration (GG, 6.5±5.8, GC, 3.3 ± 4.4; CC, 2.3±3.1 mg/L; p= 0.02). Subjects with CAD or myocardial infarction (MI) had significantly higher plasma CRP concentration than that in controls (CAD vs. controls, 8.9±18.9 vs. 3.3±7.2 mg/L; p<0.001), while patients with MI showed higher CRP when compared to those with chronic stable angina (13.5 ±22.9 vs. 5.2±14.1 mg/L; p <0.001). However, this polymorphism was not associated with CAD in our population. Conclusion: Our data suggest that human CRP gene 1059 G>C polymorphism is associated with plasma CRP concentration among Chinese in Taiwan receiving coronary angiography.

AB - Background/Purpose: Elevation of C-reactive protein (CRP) level is associated with increased risk of cardiovascular events. The 1059 G > C polymorphism in exon 2 of the CRP gene has been shown to affect plasma concentration of CRP. We want to elucidate the effect of this polymorphism on the development of coronary artery disease (CAD) among the Chinese population in Taiwan. Methods: We scrutinized 536 patients undergoing coronary angiography (365 patients with CAD and 171 controls with patent coronaries) and evaluated the association of CRP gene 1059 G > C polymorphism with CAD. Genotyping of the polymorphism was performed by polymerase chain reaction and MaeIII restriction enzyme digestion. Results: The CC genotype was associated with lower plasma CRP concentration (GG, 6.5±5.8, GC, 3.3 ± 4.4; CC, 2.3±3.1 mg/L; p= 0.02). Subjects with CAD or myocardial infarction (MI) had significantly higher plasma CRP concentration than that in controls (CAD vs. controls, 8.9±18.9 vs. 3.3±7.2 mg/L; p<0.001), while patients with MI showed higher CRP when compared to those with chronic stable angina (13.5 ±22.9 vs. 5.2±14.1 mg/L; p <0.001). However, this polymorphism was not associated with CAD in our population. Conclusion: Our data suggest that human CRP gene 1059 G>C polymorphism is associated with plasma CRP concentration among Chinese in Taiwan receiving coronary angiography.

KW - C-reactive protein

KW - CAD

KW - Coronary artery disease

KW - CRP

KW - Genetic polymorphism

KW - MI

KW - Myocardial infarction

KW - C-reactive protein

KW - CAD

KW - Coronary artery disease

KW - CRP

KW - Genetic polymorphism

KW - MI

KW - Myocardial infarction

UR - http://www.scopus.com/inward/record.url?scp=34250616292&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250616292&partnerID=8YFLogxK

U2 - 10.1016/S0929-6646(09)60319-3

DO - 10.1016/S0929-6646(09)60319-3

M3 - Article

C2 - 17561469

AN - SCOPUS:34250616292

VL - 106

SP - 347

EP - 354

JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

SN - 0929-6646

IS - 5

ER -