HUMAN β‐ENDORPHIN: SYNTHESIS AND BIOLOGICAL ACTIVITY OF ANALOGS WITH SUBSTITUTIONS IN POSITIONS 2, 9, 18, 27 AND 31

HIN‐WING ‐W YEUNG, DONALD YAMASHIRO, LIANG‐FU ‐F TSENG, WEN‐CHANG ‐C CHANG, CHOH HAO LI

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Abstract

Four analogs of the opioid peptide human β‐endorphin (βh‐EP) have been synthesized: [d‐Lys9,Phe27,Gly31]‐βh‐EP, [d‐Phe18,Phe27,Gly31)‐βh‐EP, [d‐Thr2,d‐Lys9,Phe27,Gly31]‐βh‐EP, and [d‐Thr2,d‐Phe18,Phe27,Gly31]‐βh‐EP. All are practically indistinguishable from βh‐EP in the guinea pig ileum assay. All show diminished analgesic potency in the mouse tail‐flick assay.

Original languageEnglish
Pages (from-to)235-238
Number of pages4
JournalInternational Journal of Peptide and Protein Research
Volume17
Issue number2
DOIs
Publication statusPublished - Jan 1 1981
Externally publishedYes

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Keywords

  • guinea pig ileum assay
  • mouse tail‐flick test
  • solid‐phase peptide synthesis
  • β‐endorphin analogs

ASJC Scopus subject areas

  • Biochemistry

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