HUMAN β‐ENDORPHIN: SYNTHESIS AND BIOLOGICAL ACTIVITY OF ANALOGS WITH SUBSTITUTIONS IN POSITIONS 2, 9, 18, 27 AND 31

HIN‐WING ‐W YEUNG, DONALD YAMASHIRO, LIANG‐FU ‐F TSENG, WEN‐CHANG ‐C CHANG, CHOH HAO LI

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Four analogs of the opioid peptide human β‐endorphin (βh‐EP) have been synthesized: [d‐Lys9,Phe27,Gly31]‐βh‐EP, [d‐Phe18,Phe27,Gly31)‐βh‐EP, [d‐Thr2,d‐Lys9,Phe27,Gly31]‐βh‐EP, and [d‐Thr2,d‐Phe18,Phe27,Gly31]‐βh‐EP. All are practically indistinguishable from βh‐EP in the guinea pig ileum assay. All show diminished analgesic potency in the mouse tail‐flick assay.

Original languageEnglish
Pages (from-to)235-238
Number of pages4
JournalInternational Journal of Peptide and Protein Research
Volume17
Issue number2
DOIs
Publication statusPublished - Jan 1 1981
Externally publishedYes

Fingerprint

Endorphins
Bioactivity
Substitution reactions
Assays
Opioid Peptides
Ileum
Analgesics
Guinea Pigs

Keywords

  • guinea pig ileum assay
  • mouse tail‐flick test
  • solid‐phase peptide synthesis
  • β‐endorphin analogs

ASJC Scopus subject areas

  • Biochemistry

Cite this

HUMAN β‐ENDORPHIN : SYNTHESIS AND BIOLOGICAL ACTIVITY OF ANALOGS WITH SUBSTITUTIONS IN POSITIONS 2, 9, 18, 27 AND 31. / YEUNG, HIN‐WING ‐W; YAMASHIRO, DONALD; TSENG, LIANG‐FU ‐F; CHANG, WEN‐CHANG ‐C; LI, CHOH HAO.

In: International Journal of Peptide and Protein Research, Vol. 17, No. 2, 01.01.1981, p. 235-238.

Research output: Contribution to journalArticle

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