HUMAN β‐ENDORPHIN Immunoreactivity of Synthetic Analogs with Various Chain Lengths

WEN‐CHANG ‐C CHANG, HIN‐WING ‐W YEUNG, CHOH HAO LI

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Immunoreactivity of synthetic human β‐endorphin analogs with various chain lengths has been examined using a specific radioimmunoassay. It was found that β‐endorphin‐(1–21) and analogs of shortened chain exhibit no immunoreactivity, whereas β‐endorphin‐(1–15) possesses significant in vitro opiate activity. It appears that immunoreactivity of β‐endorphin resides in the COOH‐terminal segment of residues (22–31). The data also show the lack of correlation between opiate and immunological activities of β‐endorphin.

Original languageEnglish
Pages (from-to)278-281
Number of pages4
JournalInternational Journal of Peptide and Protein Research
Volume13
Issue number3
DOIs
Publication statusPublished - Jan 1 1979
Externally publishedYes

Fingerprint

Endorphins
Chain length
Opiate Alkaloids
Radioimmunoassay

Keywords

  • opiate activity
  • radioimmunoassay
  • β‐lipotropin

ASJC Scopus subject areas

  • Biochemistry

Cite this

HUMAN β‐ENDORPHIN Immunoreactivity of Synthetic Analogs with Various Chain Lengths. / CHANG, WEN‐CHANG ‐C; YEUNG, HIN‐WING ‐W; LI, CHOH HAO.

In: International Journal of Peptide and Protein Research, Vol. 13, No. 3, 01.01.1979, p. 278-281.

Research output: Contribution to journalArticle

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