How do resting state changes in depression translate into psychopathological symptoms? from 'Spatiotemporal correspondence' to 'Spatiotemporal Psychopathology'

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Purpose of review To review the recent findings in resting-state activity in major depressive disorder (MDD) and link them to psychopathological symptoms. Recent findings MDD shows changes in resting state functional connectivity (rsFC) mainly within the default-mode network with a focus on especially the perigenual anterior cingulate cortex. rsFC in perigenual anterior cingulated cortex is abnormally high in MDD and decreased in the lateral prefrontal cortex with the central executive network (CEN). rsFC in other networks like the salience network, including the insula, amygdala, and supragenual anterior cingulate cortex and the sensorimotor network is also affected in MDD. Summary Resting-state activity in MDD shows abnormal topographical and spatiotemporal pattern. The spatiotemporal alterations in resting state may translate into corresponding spatiotemporal changes underlying the sensorimotor, affective, and cognitive functions, and thus, the various symptoms. Such spatiotemporal correspondence between resting state changes and psychopathological symptoms may make necessary the development of what I describe as 'Spatiotemporal Psychopathology'.
Original languageEnglish
Pages (from-to)18-24
Number of pages7
JournalCurrent Opinion in Psychiatry
Volume29
Issue number1
DOIs
Publication statusPublished - 2016

Fingerprint

Major Depressive Disorder
Psychopathology
Depression
Gyrus Cinguli
Amygdala
Prefrontal Cortex
Cognition

Cite this

@article{89698ecd06c34795908b0fcd98ea77dd,
title = "How do resting state changes in depression translate into psychopathological symptoms? from 'Spatiotemporal correspondence' to 'Spatiotemporal Psychopathology'",
abstract = "Purpose of review To review the recent findings in resting-state activity in major depressive disorder (MDD) and link them to psychopathological symptoms. Recent findings MDD shows changes in resting state functional connectivity (rsFC) mainly within the default-mode network with a focus on especially the perigenual anterior cingulate cortex. rsFC in perigenual anterior cingulated cortex is abnormally high in MDD and decreased in the lateral prefrontal cortex with the central executive network (CEN). rsFC in other networks like the salience network, including the insula, amygdala, and supragenual anterior cingulate cortex and the sensorimotor network is also affected in MDD. Summary Resting-state activity in MDD shows abnormal topographical and spatiotemporal pattern. The spatiotemporal alterations in resting state may translate into corresponding spatiotemporal changes underlying the sensorimotor, affective, and cognitive functions, and thus, the various symptoms. Such spatiotemporal correspondence between resting state changes and psychopathological symptoms may make necessary the development of what I describe as 'Spatiotemporal Psychopathology'.",
author = "Northoff, {Georg Franz Josef}",
note = "Export Date: 30 March 2016",
year = "2016",
doi = "10.1097/YCO.0000000000000222",
language = "English",
volume = "29",
pages = "18--24",
journal = "Current Opinion in Psychiatry",
issn = "0951-7367",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - How do resting state changes in depression translate into psychopathological symptoms? from 'Spatiotemporal correspondence' to 'Spatiotemporal Psychopathology'

AU - Northoff, Georg Franz Josef

N1 - Export Date: 30 March 2016

PY - 2016

Y1 - 2016

N2 - Purpose of review To review the recent findings in resting-state activity in major depressive disorder (MDD) and link them to psychopathological symptoms. Recent findings MDD shows changes in resting state functional connectivity (rsFC) mainly within the default-mode network with a focus on especially the perigenual anterior cingulate cortex. rsFC in perigenual anterior cingulated cortex is abnormally high in MDD and decreased in the lateral prefrontal cortex with the central executive network (CEN). rsFC in other networks like the salience network, including the insula, amygdala, and supragenual anterior cingulate cortex and the sensorimotor network is also affected in MDD. Summary Resting-state activity in MDD shows abnormal topographical and spatiotemporal pattern. The spatiotemporal alterations in resting state may translate into corresponding spatiotemporal changes underlying the sensorimotor, affective, and cognitive functions, and thus, the various symptoms. Such spatiotemporal correspondence between resting state changes and psychopathological symptoms may make necessary the development of what I describe as 'Spatiotemporal Psychopathology'.

AB - Purpose of review To review the recent findings in resting-state activity in major depressive disorder (MDD) and link them to psychopathological symptoms. Recent findings MDD shows changes in resting state functional connectivity (rsFC) mainly within the default-mode network with a focus on especially the perigenual anterior cingulate cortex. rsFC in perigenual anterior cingulated cortex is abnormally high in MDD and decreased in the lateral prefrontal cortex with the central executive network (CEN). rsFC in other networks like the salience network, including the insula, amygdala, and supragenual anterior cingulate cortex and the sensorimotor network is also affected in MDD. Summary Resting-state activity in MDD shows abnormal topographical and spatiotemporal pattern. The spatiotemporal alterations in resting state may translate into corresponding spatiotemporal changes underlying the sensorimotor, affective, and cognitive functions, and thus, the various symptoms. Such spatiotemporal correspondence between resting state changes and psychopathological symptoms may make necessary the development of what I describe as 'Spatiotemporal Psychopathology'.

U2 - 10.1097/YCO.0000000000000222

DO - 10.1097/YCO.0000000000000222

M3 - Article

C2 - 26651006

VL - 29

SP - 18

EP - 24

JO - Current Opinion in Psychiatry

JF - Current Opinion in Psychiatry

SN - 0951-7367

IS - 1

ER -