How can the brain's resting state activity generate hallucinations? A 'resting state hypothesis' of auditory verbal hallucinations

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Abstract

While several hypotheses about the neural mechanisms underlying auditory verbal hallucinations (AVH) have been suggested, the exact role of the recently highlighted intrinsic resting state activity of the brain remains unclear. Based on recent findings, we therefore developed what we call the 'resting state hypotheses' of AVH. Our hypothesis suggest that AVH may be traced back to abnormally elevated resting state activity in auditory cortex itself, abnormal modulation of the auditory cortex by anterior cortical midline regions as part of the default-mode network, and neural confusion between auditory cortical resting state changes and stimulus-induced activity. We discuss evidence in favour of our 'resting state hypothesis' and show its correspondence with phenomenological accounts. © 2010 Elsevier B.V.
Original languageEnglish
Pages (from-to)202-214
Number of pages13
JournalSchizophrenia Research
Volume127
Issue number1-3
DOIs
Publication statusPublished - 2011
Externally publishedYes

Fingerprint

Hallucinations
Auditory Cortex
Brain

Keywords

  • Auditory cortex
  • Auditory verbal hallucinations
  • Resting state
  • Schizophrenia
  • anterior cingulate
  • auditory cortex
  • auditory stimulation
  • auditory verbal hallucination
  • delusion
  • diagonal band of Broca
  • evoked auditory response
  • hallucination
  • human
  • middle temporal gyrus
  • mismatch negativity
  • neuroimaging
  • neuromodulation
  • phenomenology
  • prefrontal cortex
  • priority journal
  • review
  • schizophrenia
  • superior temporal gyrus
  • visual hallucination
  • working memory
  • Auditory Cortex
  • Brain Mapping
  • Hallucinations
  • Humans
  • Neural Pathways
  • Rest
  • Verbal Behavior

Cite this

@article{35e520d5ef244e0095de81fb215aabc1,
title = "How can the brain's resting state activity generate hallucinations? A 'resting state hypothesis' of auditory verbal hallucinations",
abstract = "While several hypotheses about the neural mechanisms underlying auditory verbal hallucinations (AVH) have been suggested, the exact role of the recently highlighted intrinsic resting state activity of the brain remains unclear. Based on recent findings, we therefore developed what we call the 'resting state hypotheses' of AVH. Our hypothesis suggest that AVH may be traced back to abnormally elevated resting state activity in auditory cortex itself, abnormal modulation of the auditory cortex by anterior cortical midline regions as part of the default-mode network, and neural confusion between auditory cortical resting state changes and stimulus-induced activity. We discuss evidence in favour of our 'resting state hypothesis' and show its correspondence with phenomenological accounts. {\circledC} 2010 Elsevier B.V.",
keywords = "Auditory cortex, Auditory verbal hallucinations, Resting state, Schizophrenia, anterior cingulate, auditory cortex, auditory stimulation, auditory verbal hallucination, delusion, diagonal band of Broca, evoked auditory response, hallucination, human, middle temporal gyrus, mismatch negativity, neuroimaging, neuromodulation, phenomenology, prefrontal cortex, priority journal, review, schizophrenia, superior temporal gyrus, visual hallucination, working memory, Auditory Cortex, Brain Mapping, Hallucinations, Humans, Neural Pathways, Rest, Verbal Behavior",
author = "Georg Northoff and Pengmin Qin",
note = "被引用次數:50 Export Date: 31 March 2016 CODEN: SCRSE 通訊地址: Northoff, G.; Mind Brain Imaging and Neuroethics, Institute of Mental Health Research (IMHR), 1145 Carling Avenue, Ottawa, ON K1Z 7K4, Canada; 電子郵件: georg.northoff@rohcg.on.ca 參考文獻: Allen, P., Aleman, A., McGuire, P.K., Inner speech models of auditory verbal hallucinations: evidence from behavioural and neuroimaging studies (2007) Int. Rev. Psychiatry, 19 (4), pp. 407-415; Allen, P., Amaro, E., Fu, C.H., Williams, S.C., Brammer, M.J., Johns, L.C., McGuire, P.K., Neural correlates of the misattribution of speech in schizophrenia (2007) Br. J. Psychiatry, 190, pp. 162-169; Allen, P., Laroi, F., McGuire, P.K., Aleman, A., The hallucinating brain: a review of structural and functional neuroimaging studies of hallucinations (2008) Neurosci. Biobehav. 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year = "2011",
doi = "10.1016/j.schres.2010.11.009",
language = "English",
volume = "127",
pages = "202--214",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",
number = "1-3",

}

TY - JOUR

T1 - How can the brain's resting state activity generate hallucinations? A 'resting state hypothesis' of auditory verbal hallucinations

AU - Northoff, Georg

AU - Qin, Pengmin

N1 - 被引用次數:50 Export Date: 31 March 2016 CODEN: SCRSE 通訊地址: Northoff, G.; Mind Brain Imaging and Neuroethics, Institute of Mental Health Research (IMHR), 1145 Carling Avenue, Ottawa, ON K1Z 7K4, Canada; 電子郵件: georg.northoff@rohcg.on.ca 參考文獻: Allen, P., Aleman, A., McGuire, P.K., Inner speech models of auditory verbal hallucinations: evidence from behavioural and neuroimaging studies (2007) Int. Rev. Psychiatry, 19 (4), pp. 407-415; Allen, P., Amaro, E., Fu, C.H., Williams, S.C., Brammer, M.J., Johns, L.C., McGuire, P.K., Neural correlates of the misattribution of speech in schizophrenia (2007) Br. J. Psychiatry, 190, pp. 162-169; Allen, P., Laroi, F., McGuire, P.K., Aleman, A., The hallucinating brain: a review of structural and functional neuroimaging studies of hallucinations (2008) Neurosci. Biobehav. 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PY - 2011

Y1 - 2011

N2 - While several hypotheses about the neural mechanisms underlying auditory verbal hallucinations (AVH) have been suggested, the exact role of the recently highlighted intrinsic resting state activity of the brain remains unclear. Based on recent findings, we therefore developed what we call the 'resting state hypotheses' of AVH. Our hypothesis suggest that AVH may be traced back to abnormally elevated resting state activity in auditory cortex itself, abnormal modulation of the auditory cortex by anterior cortical midline regions as part of the default-mode network, and neural confusion between auditory cortical resting state changes and stimulus-induced activity. We discuss evidence in favour of our 'resting state hypothesis' and show its correspondence with phenomenological accounts. © 2010 Elsevier B.V.

AB - While several hypotheses about the neural mechanisms underlying auditory verbal hallucinations (AVH) have been suggested, the exact role of the recently highlighted intrinsic resting state activity of the brain remains unclear. Based on recent findings, we therefore developed what we call the 'resting state hypotheses' of AVH. Our hypothesis suggest that AVH may be traced back to abnormally elevated resting state activity in auditory cortex itself, abnormal modulation of the auditory cortex by anterior cortical midline regions as part of the default-mode network, and neural confusion between auditory cortical resting state changes and stimulus-induced activity. We discuss evidence in favour of our 'resting state hypothesis' and show its correspondence with phenomenological accounts. © 2010 Elsevier B.V.

KW - Auditory cortex

KW - Auditory verbal hallucinations

KW - Resting state

KW - Schizophrenia

KW - anterior cingulate

KW - auditory cortex

KW - auditory stimulation

KW - auditory verbal hallucination

KW - delusion

KW - diagonal band of Broca

KW - evoked auditory response

KW - hallucination

KW - human

KW - middle temporal gyrus

KW - mismatch negativity

KW - neuroimaging

KW - neuromodulation

KW - phenomenology

KW - prefrontal cortex

KW - priority journal

KW - review

KW - schizophrenia

KW - superior temporal gyrus

KW - visual hallucination

KW - working memory

KW - Auditory Cortex

KW - Brain Mapping

KW - Hallucinations

KW - Humans

KW - Neural Pathways

KW - Rest

KW - Verbal Behavior

U2 - 10.1016/j.schres.2010.11.009

DO - 10.1016/j.schres.2010.11.009

M3 - Article

C2 - 21146961

VL - 127

SP - 202

EP - 214

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

IS - 1-3

ER -