How can the brain's resting state activity generate hallucinations? A 'resting state hypothesis' of auditory verbal hallucinations

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116 Citations (Scopus)

Abstract

While several hypotheses about the neural mechanisms underlying auditory verbal hallucinations (AVH) have been suggested, the exact role of the recently highlighted intrinsic resting state activity of the brain remains unclear. Based on recent findings, we therefore developed what we call the 'resting state hypotheses' of AVH. Our hypothesis suggest that AVH may be traced back to abnormally elevated resting state activity in auditory cortex itself, abnormal modulation of the auditory cortex by anterior cortical midline regions as part of the default-mode network, and neural confusion between auditory cortical resting state changes and stimulus-induced activity. We discuss evidence in favour of our 'resting state hypothesis' and show its correspondence with phenomenological accounts. © 2010 Elsevier B.V.
Original languageEnglish
Pages (from-to)202-214
Number of pages13
JournalSchizophrenia Research
Volume127
Issue number1-3
DOIs
Publication statusPublished - 2011
Externally publishedYes

Keywords

  • Auditory cortex
  • Auditory verbal hallucinations
  • Resting state
  • Schizophrenia
  • anterior cingulate
  • auditory cortex
  • auditory stimulation
  • auditory verbal hallucination
  • delusion
  • diagonal band of Broca
  • evoked auditory response
  • hallucination
  • human
  • middle temporal gyrus
  • mismatch negativity
  • neuroimaging
  • neuromodulation
  • phenomenology
  • prefrontal cortex
  • priority journal
  • review
  • schizophrenia
  • superior temporal gyrus
  • visual hallucination
  • working memory
  • Auditory Cortex
  • Brain Mapping
  • Hallucinations
  • Humans
  • Neural Pathways
  • Rest
  • Verbal Behavior

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