Host and microbiologic factors associated with mortality in Taiwanese children with invasive pneumococcal diseases, 2001 to 2006

Chih Jung Chen, Chia Ling Lin, Yi Ching Chen, Chun Wei Wang, Cheng Hsun Chiu, Tzou Yien Lin, Yhu Chering Huang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We concurrently evaluated host- and organism-related factors in determining the outcomes of 160 invasive pneumococcal diseases episodes in 158 Taiwanese children during 2001 and 2006. Most (138/160, 86.2%) episodes occurred at age less than 60 months, and an underlying condition was present in 35 (22.2%) cases. Common disease syndromes included complicated pneumonia (29.4%), uncomplicated pneumonia (29.4%), occult bacteremia (17.5%), and meningitis (14.4%). Mortality (13/160, 8.1%) was associated with age less than 24 months, underlying conditions, meningitis, cytopenia, intensive care, and penicillin MIC ≥2 μg/mL in univariate analysis. Pneumococcal serotypes, genotypes, origin of infections, and discordant therapy did not influence the outcome. Multivariate analysis determined the presence of underlying conditions (adjusted odds ratio [OR], 30.5; 95% confidence interval [CI], 4.8-193.1) and penicillin MIC ≥2 μg/mL (adjusted OR, 8.1; 95% CI, 1.4-47.3), which are the independent predictors for fatality. This finding highlighted the importance of immunization of disadvantaged children, targeting drug-resistant pneumococci.

Original languageEnglish
Pages (from-to)194-200
Number of pages7
JournalDiagnostic Microbiology and Infectious Disease
Volume63
Issue number2
DOIs
Publication statusPublished - Feb 2009
Externally publishedYes

Fingerprint

Meningitis
Penicillins
Pneumonia
Odds Ratio
Confidence Intervals
Mortality
Vulnerable Populations
Drug Delivery Systems
Critical Care
Bacteremia
Streptococcus pneumoniae
Immunization
Multivariate Analysis
Genotype
Infection
Therapeutics
Serogroup

Keywords

  • Antibiotic resistance
  • Children
  • Genotypes
  • Invasive pneumococcal diseases
  • Risk factors
  • Serotypes
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Host and microbiologic factors associated with mortality in Taiwanese children with invasive pneumococcal diseases, 2001 to 2006. / Chen, Chih Jung; Lin, Chia Ling; Chen, Yi Ching; Wang, Chun Wei; Chiu, Cheng Hsun; Lin, Tzou Yien; Huang, Yhu Chering.

In: Diagnostic Microbiology and Infectious Disease, Vol. 63, No. 2, 02.2009, p. 194-200.

Research output: Contribution to journalArticle

Chen, Chih Jung ; Lin, Chia Ling ; Chen, Yi Ching ; Wang, Chun Wei ; Chiu, Cheng Hsun ; Lin, Tzou Yien ; Huang, Yhu Chering. / Host and microbiologic factors associated with mortality in Taiwanese children with invasive pneumococcal diseases, 2001 to 2006. In: Diagnostic Microbiology and Infectious Disease. 2009 ; Vol. 63, No. 2. pp. 194-200.
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