Homology models of main proteinase from coronavirus associated with SARS

Hsuan Liang Liu, Jin Chung Lin, Yih Ho, Chin Wen Chen

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In this study, two homology models of the main proteinase (M pro) from the novel coronavirus associated with severe acute respiratory syndrome (SARS-CoV) were constructed. These models reveal three distinct functional domains, in which an intervening loop connecting domains II and III as well as a catalytic cleft containing the substrate binding subsites S1 and S2 between domains I and II are observed. S2 exhibits structural variations more significantly than S1 during the 200 ps molecular dynamics simulations because it is located at the open mouth of the catalytic cleft and the amino acid residues lining up this subsite are least conserved. In addition, the higher structural variation of S2 makes it flexible enough to accommodate a bulky hydrophobic residue from the substrate.

Original languageEnglish
Pages (from-to)24-29
Number of pages6
JournalChemical Physics Letters
Volume401
Issue number1-3
DOIs
Publication statusPublished - Jan 1 2005

Fingerprint

homology
Substrates
Linings
Molecular dynamics
Peptide Hydrolases
mouth
linings
Amino Acids
amino acids
Computer simulation
molecular dynamics
Coronavirus 3C-like proteinase
simulation

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Spectroscopy
  • Atomic and Molecular Physics, and Optics

Cite this

Homology models of main proteinase from coronavirus associated with SARS. / Liu, Hsuan Liang; Lin, Jin Chung; Ho, Yih; Chen, Chin Wen.

In: Chemical Physics Letters, Vol. 401, No. 1-3, 01.01.2005, p. 24-29.

Research output: Contribution to journalArticle

Liu, Hsuan Liang ; Lin, Jin Chung ; Ho, Yih ; Chen, Chin Wen. / Homology models of main proteinase from coronavirus associated with SARS. In: Chemical Physics Letters. 2005 ; Vol. 401, No. 1-3. pp. 24-29.
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