Home sleep study for patients with myasthenia gravis

J. H. Yeh, C. M. Lin, H. C. Chiu, C. H. Bai

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives: The objective of the study was to examine predictors for sleep-disordered breathing (SDB) in patients with myasthenia gravis (MG) using Watch-PAT. Materials and Methods: We prospectively studied 58 consecutive patients with MG without respiratory symptoms for a full-night Watch-PAT with concomitant recording of the MG score and acetylcholine receptor antibody concentration and analyzed potential risk factors of SDB. Results: Twenty-four patients (41%) had definitive SDB, which was mild in 12 patients, moderate in six, and severe in six. Assessing risk factors with multivariate models, we found four significant predictors (BMI, age, male gender, and use of azathioprine); BMI was the most powerful predictor. The severity and prevalence of sleep-disordered breathing had no significant association with MG score, myasthenia stage, or seropositivity of acetylcholine receptor antibody. Conclusions: The prevalence of SDB in myasthenic patients with mild and moderate weakness was high when using the Watch-PAT. Both myasthenia-specific factors (use of azathioprine) and general predictors in terms of BMI, age, and male gender predisposed the development of SDB in patients with myasthenia gravis. Careful screening of patients with myasthenia gravis at risk of SDB using Watch-PAT might improve the quality of sleep and cardiovascular health through proper treatment of underlying SDB.

Original languageEnglish
Pages (from-to)191-195
Number of pages5
JournalActa Neurologica Scandinavica
Volume132
Issue number3
DOIs
Publication statusPublished - 2015

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Keywords

  • acetylcholine receptor antibody
  • body mass index
  • myasthenia gravis
  • peripheral arterial tone
  • polysomnography
  • sleep-disordered breathing

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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